Comparative genomics the wealth of ‘omics data

The comparative genomics group exploits the wealth of ‘omics data to predict the function of proteins and their involvement in protein complexes and pathways. On the one hand we develop methods to analyse new types of ‘omics data in an integrative manner. On the other hand we collaborate with groups in the Radboudumc and in the scientific community as a whole to analyze their data and arrive at specific predictions about the function of proteins. In this we specifically focus on mitochondria, for which we have successfully predicted the functions of many medically relevant proteins. Furthermore we collaborate with groups working on Malaria and with the group working on Children infectious’ diseases to develop better vaccines. In our analyses we often include an evolutionary angle allowing us to exploit the large numbers of available genomes and the information that evolutionary conservation contains about protein function and protein interactions.
 
People Martijn Huijnen Comparative genomics

Comparative genomics the wealth of ‘omics data

The comparative genomics group exploits the wealth of ‘omics data to predict the function of proteins and their involvement in protein complexes and pathways.

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Research group leader

Martijn Huijnen PhD

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Aims of this research group

  • Integrative analysis of ‘omics data for high resolution and reliable protein function prediction.


Discoveries of this research group

  • This research group discovered numerous mitochondrial and ciliary disease genes.

Team

Radboudumc Technology Center Bioinformatics

The Bioinformatics technology center aims to raise and solve biological questions using the most recent computer technologies and big data solutions.

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Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes. read more