Comparative genomics the wealth of ‘omics data

The comparative genomics group exploits the wealth of ‘omics data to predict the function of proteins and their involvement in protein complexes and pathways. On the one hand we develop methods to analyse new types of ‘omics data in an integrative manner. On the other hand we collaborate with groups in the Radboudumc and in the scientific community as a whole to analyze their data and arrive at specific predictions about the function of proteins. In this we specifically focus on mitochondria, for which we have successfully predicted the functions of many medically relevant proteins. Furthermore we collaborate with groups working on Malaria and with the group working on Children infectious’ diseases to develop better vaccines. In our analyses we often include an evolutionary angle allowing us to exploit the large numbers of available genomes and the information that evolutionary conservation contains about protein function and protein interactions.
 
People Martijn Huijnen Comparative genomics

Comparative genomics the wealth of ‘omics data

The comparative genomics group exploits the wealth of ‘omics data to predict the function of proteins and their involvement in protein complexes and pathways.

read more

Research group leader

Martijn Huijnen PhD

contact

Aims of this research group

  • Integrative analysis of ‘omics data for high resolution and reliable protein function prediction.


Discoveries of this research group

  • This research group discovered numerous mitochondrial and ciliary disease genes.

Team

Related research groups


Research group Drosophila models of brain disorders and neurogenetics

Annette Schenck's research focuses on dissecting molecular networks and mechanisms underlying human brain function and disease. In order to be able to investigate the large number of genes, we use a powerful genetic model organism, the fruitfly Drosophila melanogaster.

read more

Research group Glycosylation Disorders in Neurology

Dirk Lefeber's research group aims to understand the mechanisms of protein- and tissue-specific glycosylation abnormalities in human disease with a focus on neurodegenerative and neuromuscular disease.

read more

Research group Human papillomaviruses (HPV)

Willem Melchers' research aims to improve the nationwide cervical cancer screening, with the possibility of using self sampling. Important herein is research on the use of new triage methods for hrHPV positive women, by using HPV genotyping or molecular biomarkers.

read more

Research group Malaria research

Robert Sauerwein's (and Teun Bousema's and Taco Kooij's) group focuses on the clinical development of plasmodium falciparum vaccines for control and elimination of malaria.

read more

Research group Molecular biology of ciliopathies

Ronald Roepman's group aims to generate detailed parts lists of the molecular machines that are active in the cilia, and identify either their structural role in the cilium, or their role in the signaling pathways that are dependent on/directed by cilia.

read more

Research group Tumor targeting

William Leenders' group performs targeted quantitative next generation sequencing of RNA from surgery-derived cancer tissues in retrospective studies, tries to translate the findings into personalized precision therapy with available cancer treatments, and develops innovative targeted nanomedicines.

read more

Radboudumc Technology Center Bioinformatics

The Bioinformatics technology center aims to raise and solve biological questions using the most recent computer technologies and big data solutions.

read more

Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes. read more