Personal prizes & awards national & international
- 2017: International Cochrane REWARD 2nd. prize
- 2011: Lef in't Lab prijs, Dierenbescherming (Dutch Organisation for the Protection for Animal Welfare)
- 2010: Price by SGV (Swiss Association for Laboratory Animal Science) for the Gold Standard Publication Checklist, as best publication in Laboratory animal science
Merel Ritskes-Hoitinga explains
Animal models help to gain insights in human diseases and possibilities for succesful clinical trails. By using systematic reviews, conducted research still appears to be very useful for this.
Q1 What is the aim of Systematic Reviews of Animal Studies?
“The group Systematic Reviews of Animal Studies summarizes already available evidence from conducted animal studies in order to increase the value and reduce the waste of research. First, we try to find all available information regarding a certain topic. Then, we make a critical appraisal of the research quality. This is called a meta-analysis. In the end, we make summaries of all available data. In doing so, we come to new conclusions and insights and we are able to identify gaps in knowledge, and give insight into the potential translation of research data for humans.”
Q2 What is the importance of the group?
Learn by constructing effectivenesses.
“We attempt to make a transparent overview of available literature, evaluate the quality of these publications and present whether studies are reproducible or not. In this way, we can construct the effectiveness (for example, costs vs. quality and translation) of animal studies.”
Q3 How do other researchers benefit from this contribution?
“We can indentify animal models and summarize evidence from animal studies in order to gain insights in human diseases and possibilities for successful clinical trials. Thereby, we can secure efficacy and safety for human patients. Making a summary of all available knowledge regarding a topic prevents unnecessary duplication of research. Moreover, all available evidence is evaluated and allocated with a quality score. This quality assessment is important as it is based on methodological requirements, for instance, the use of randomization and blinding which are the basic starting points of our scientific practice.”
Q4 Can you give an insight in the review process?
“First, you start with a research question. After that, respectively, you search for literature, select relevant references, select relevant full text articles, extract relevant data, asses study quality, and – if possible – statistically analyze all data together (meta-analysis).”
Q5 What are goals for the future?
“The group Systematic Reviews of Animal Studies for animal studies arose from SYRCLE, a center that promotes the concept of systematic reviews of animal studies. The group is relatively new and unknown. Therefore, it is interesting to constantly make the methodology more appealing and to improve the quality of our tools. We also find that much executed research is insufficient. Researchers need to be enforced to follow drafted reporting guidelines. In 2020, the EU will evaluate the new legislation. I have suggested to the EU to designate that year as ‘the year of the systematic reviews’.”
Merel Ritskes-Hoitinga is head of Systematic Reviews of Animal Studies. Within her career as a researcher, she often relies on Zen meditation. The accompanying techniques enable her to create different points of view, break with research routines and eventually tread new paths.
Research group SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE)
Merel Ritskes-Hoitinga's research subgroup aims to increase the value and reduce the waste of research in animal studies.read more