Center of Expertise in Mycology Radboudumc/CWZ

This centre offers expert consultation for patients with complex fungal diseases. A multidisciplinary team including infectious disease specialists, consultant microbiologists and clinical pharmacologists works together to (help) diagnose the fungal disease and to develop individual treatment plans based on fungus identification and host factors.
 
The center hosts the National Mycology Reference Laboratory and coordinates the national resistance surveillance program. Research focuses on many aspects of fungal diseases including host factors, drug interactions and efficacy and mycology.
 
Furthermore, basic and advanced training courses in different aspects of mycology and fungal diseases are organized.
 
People Paul Verweij Mycology

Identification of fungal infections

Our research group is primarily focused on fungal infections. We aim to develop methods for rapid and reliable identification of fungal infections in order to start early treatment and therefore improve the outcome for patients.

Research group leader

Paul Verweij MD PhD
full professor

+31 (0)24 361 90 41

Contact

Aims

Our research aims to improve the survival chances of immunocompromised patients. Another field of interest is the development of azole drug resistance in the fungus species Aspergillus.

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Aims

The fungus Aspergillus

Even though fungi are important for degradation of organic waste and are used to produce certain medicines, such as penicillin, and may be very tasty to eat, they can also cause very severe, often life-threatening diseases in humans. Mainly immunocompromised patients (leukaemia patients who receive chemotherapy, stem cell transplant recipients or solid organ transplant patients) seem to be very receptive to fungal infections which are often caused by the fungus Aspergillus. These infections may prove difficult to diagnose and to treat.
Our research aims to improve the survival chances of these immunocompromised patients. We are developing methods for rapid and reliable identification of fungal infections in order to start early treatment and therefore improve the outcome for patients.

Azole resistance in Aspergillus fumigatus

Another field of interest is the development of azole drug resistance in Aspergillus species. Azole resistance is a growing public health concern, with reported azole resistance now found worldwide. In the Netherlands high resistance frequencies are reported, as high as 30% in critically ill patients. The mortality of azole-resistant invasive aspergillosis is high and treatment options are very limited.
 
Our research focuses on the development of resistance in the environment. Azole fungicides are widely used from material preservation and crop protection, which is thought to be an important route of resistance selection in A. fumigatus. Together with Wageningen University, environmental studies are performed to understand and manage resistance selection.
 
Epidemiology, early detection and management are other important research aims.

Center of Expertise in Mycology Radboudumc/CWZ

This centre offers expert consultation for patients with complex fungal diseases. A multidisciplinary team works together to (help) diagnose the fungal disease and to develop individual treatment plans based on fungus identification and host factors.

read more

Interesting links

Team

Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes. read more
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