Collaborations

  • Prof.dr. Antonios G Mikos (Rice University, Houston, USA)
  • Prof.dr. Pamela Yelick (Tufts University, Boston, USA)
  • Prof.dr. Li Yubao (Chengdu University, China)
  • Prof.dr. Huanan Wang (Shenzhen University, China)
  • Dr. Jinling Ma (Beijing Capital Medical University, China)
  • Prof.dr. Xinquan Jiang (Shanghai Jiao Tong University, China)
  • Prof.dr. Jan van Hest (Technical University Eindhoven, the Netherlands)
  • Prof.dr. Pamela Habibovic (Maastricht University, the Netherlands)
  • Prof.dr. Lorenzo Moroni (Maastricht University, the Netherlands)
  • Prof. Marcel Karperien (University of Twente, the Netherlands)
  • Dr. Jos Paulusse (University of Twente, the Netherlands)
  • Prof.dr. Aldo Boccaccini (University of Erlangen, Germany)
  • Prof.dr. Pierre Layrolle (University of Nantes, France)
  • Prof.dr. Nico Margiotta (University of Bari, Italy)
  • Dr. Michele Iafisco (CNR ISTEC, Faenza, Italy)
  • Prof.dr. Annelie Weinberg (Graz University, Graz, Austria)
People Sander Leeuwenburgh Regenerative biomaterials

Regenerative biomaterials development of advanced tissue regenerative therapies

The Regenerative Biomaterials research group at Radboudumc creates novel biomaterial-based therapies for regeneration of hard tissues. Overall, our main aim is to decipher which physicochemical properties of biomaterials are able to trigger the natural self-healing capacity of hard tissues.

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Regenerative biomaterials development of advanced tissue regenerative therapies

The Regenerative Biomaterials research group at Radboudumc creates novel biomaterial-based therapies for regeneration of hard tissues. Overall, our main aim is to decipher which physicochemical properties of biomaterials are able to trigger the natural self-healing capacity of hard tissues. Our design philosophy is highly translational and aimed at bridging the gap between basic and clinical sciences. To this end, experimental data are translated to pre-clinical (animal) and clinical (human) studies to benefit patients.

We strive to overcome major shortcomings of conventional biomaterials by smart design of biomaterials with improved biological, mechanical and handling performance. To this end, we synthesize a wide range of nano- and microstructured biomaterials including injectable, biodegradable and self-healing 3D hydrogels and cements, 2D barrier membranes and coatings, as well as organic or inorganic nanoparticles. These biomaterials are functionalized with various types of therapeutic biomolecules (e.g. antibacterial or anti-cancer drugs) and/or patient-derived cells (e.g. stem cells or immune cells) to tune their capacity to induce tissue regeneration for both healthy and diseased patients.

Research group leader

Sander Leeuwenburgh PhD

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Aims of this research group

  • designing novel biomaterial-based therapies with superior regenerative efficacy
  • deciphering which physicochemical properties of biomaterials trigger the natural self-healing capacity of hard tissues
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Aims of this research group

This research group aims:
  • to design novel biomaterial-based therapies with superior regenerative efficacy;
  • to decipher which physicochemical properties of biomaterials trigger the natural self-healing capacity of hard tissues;
  • to maximize the regenerative capacity of biomaterials by functionalization with cells and therapeutic biomolecules;
  • to develop predictive models for hard tissue regeneration.

Discoveries by this research group

  • fully resorbable bioceramic bone cements
  • self-healing biomaterials for hard tissue regeneration
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Discoveries by this research group

Some discoveries by this research group are:
  • fully resorbable bioceramic bone cements;
  • self-healing biomaterials for hard tissue regeneration;
  • superior biological and mechanical performance of nanostructured biomaterials;
  • osteoclast-induced bone regeneration.

Collaborations

  • Prof.dr. Antonios G Mikos (Rice University, Houston, USA)
  • Prof.dr. Pamela Yelick (Tufts University, Boston, USA)
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International collaborations with other research groups

This research group collaborates with several other (international) research groups outside Radboudumc:

  • Prof.dr. Antonios G Mikos (Rice University, Houston, US)
  • Prof.dr. Annelie Weinberg (Graz University, Graz, Austria)
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International collaborations with other research groups

  • Prof.dr. Antonios G Mikos (Rice University, Houston, US)
  • Prof.dr. Annelie Weinberg (Graz University, Graz, Austria)
  • Prof.dr. Li Yubao (Chengdu University, Chengdu, China)
  • Dr. Jinling Ma (Beijing Capital Medical University, Beijing, China)
  • Prof.dr. Jan van Hest (Technical University Eindhoven, Eindhoven, the Netherlands)
  • Prof.dr. Pamela Habibovic (Maastricht University, Maastricht, the Netherlands)

Team

Radboudumc Technology Center Animal research facility

This technology center offers advice and support from planning up to and including the conduct of animal research on behalf of biomedical research and education.

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Radboudumc Technology Center Data stewardship

The Radboudumc Technology Center Data Stewardship provides knowledge, services and solutions to fulfill your research ICT needs in a way that suits each individual study.

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Radboudumc Technology Center Flow cytometry

At the Radboudumc extensive experience in flow cytometry is used in basic and translational research as well as clinical practice and clinical trials. We offer scientists advice and access to flow cytometry analyzers and sorters.

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Radboudumc Technology Center Imaging

The Imaging Technology Center provides cutting-edge technology and service for imaging-related preclinical and clinical research questions. This covers the spectrum from molecule to man to population.

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Radboudumc Technology Center Microscopy

The Microscopic Imaging Center offers access to both standard and innovative advanced microscopy infrastructure and applications including technical operator-assistance and in-depth microscopic imaging knowledge.

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Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes. read more