The mechanistic coupling between (ultra)structure and function
Werner Koopmans' research group focuses on understanding the mechanistic coupling between mitochondrial (ultra)structure and function (“morphofunction”) in patients with (mitochondrial) metabolic disorders.read more
AimsThe following research questions are addressed:
- How can we quantify mitochondrial morphofunction at the single cell level?
- How are mitochondrial (ultra)structure and (dys)function connected?
- How is mitochondrial (dys)function linked to cellular (dys)function?
- How does mitochondrial (ultra)structure affect mitochondrial bioreactions?
- How do cells adapt to mitochondrial dysfunction?
- Can we create artificial mitochondrial with a biomimetic structure?
- Are mitochondrial morphofunctional phenotypes patient-specific?
- How can we use machine learning and deep learning for image analysis?
- How can mitochondrial (ultra)structure be therapeutically targeted?
- Mitochondrial dysfunction alters ROS/redox/calcium/glucose/ATP homeostasis
- Antioxidants mitigate mitochondrial dysfunction at the cellular level
- Mitochondrial internal structure affects biomolecular diffusion
- Inhibition of mitochondrial function can be used to target melanoma cells
- Cell metabolism rapidly adapts to mitochondrial dysfunction