Tumor targeting developing innovative nanomedicines
This research group's interest is to use information on the molecular cancer biology in individual patients that determines clinical behavior, response and non-response to therapies and contributes to the development of therapy resistance.
read moreTumor targeting developing innovative nanomedicines
Our research interest is to use information on the molecular cancer biology in individual patients that determines clinical behavior, response and non-response to therapies and contributes to the development of therapy resistance. In our research group we use surgically-derived clinical tumor material, patient-derived cell lines and orthotopic xenograft models as tools. Using a novel technique of targeted RNA next generation sequencing, in combination with computational biology, we are able to establish a reliable molecular diagnosis and a prognosis for individual patients. The aim is to translate the results of this test into better personalized cancer therapies/patient stratification.A second line of preclinical research is based on targeted delivery of nanomedicines to cancer. We have developed site directed conjugation protocols for llama single domain antibodies (VHHs) with full retention of biological activity, and showed that VHHs, conjugated to photosensitizers allow targeted photodynamic therapy (tPDT). The great advantage of tPDT as compared to conventional therapies is that it induces acute cell death via cell membrane peroxidation in a specific and selective fashion and therefore precludes development of treatment resistance.
Aims of this research group
The aim of the tumor targeting research group is two-fold:
- to translate novel biomarkers, identified by RNA sequencing in clinical cancers, into novel treatment modalities that are tested in
- to develop novel targeted nanomedicine-based treatment concepts that are tested in cell lines and preclinical cancer models
Social media research group leader
Team

Radboudumc Technology Center Animal research facility
This technology center offers advice and support from planning up to and including the conduct of animal research on behalf of biomedical research and education.
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Radboudumc Technology Center Bioinformatics
The Bioinformatics technology center aims to raise and solve biological questions using the most recent computer technologies and big data solutions.
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Radboudumc Technology Center Biostatistics
Through the Radboudumc Technology Center for Biostatistics researchers have access to collaboration with a specialist statisticians who are able to keep up with fast-moving developments in the relevant area.
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Radboudumc Technology Center Flow cytometry
At the Radboudumc extensive experience in flow cytometry is used in basic and translational research as well as clinical practice and clinical trials. We offer scientists advice and access to flow cytometry analyzers and sorters.
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Radboudumc Technology Center Genomics
The Genomics Technology Center offers state-of-the-art expertise in the forefront of sequencing technology developments.
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Radboudumc Technology Center Radboud Biobank
The Radboud Biobank collects, stores and manages biomaterial and the matching clinical data for the Radboudumc.
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