Tumor targeting developing innovative nanomedicines
This research group's interest is to use information on the molecular cancer biology in individual patients that determines clinical behavior, response and non-response to therapies and contributes to the development of therapy resistance.read more
Tumor targeting developing innovative nanomedicinesOur research interest is to use information on the molecular cancer biology in individual patients that determines clinical behavior, response and non-response to therapies and contributes to the development of therapy resistance. In our research group we use surgically-derived clinical tumor material, patient-derived cell lines and orthotopic xenograft models as tools. Using a novel technique of targeted RNA next generation sequencing, in combination with computational biology, we are able to establish a reliable molecular diagnosis and a prognosis for individual patients. The aim is to translate the results of this test into better personalized cancer therapies/patient stratification.
A second line of preclinical research is based on targeted delivery of nanomedicines to cancer. We have developed site directed conjugation protocols for llama single domain antibodies (VHHs) with full retention of biological activity, and showed that VHHs, conjugated to photosensitizers allow targeted photodynamic therapy (tPDT). The great advantage of tPDT as compared to conventional therapies is that it induces acute cell death via cell membrane peroxidation in a specific and selective fashion and therefore precludes development of treatment resistance.
Aims of this research group
The aim of the tumor targeting research group is two-fold:
- to translate novel biomarkers, identified by RNA sequencing in clinical cancers, into novel treatment modalities that are tested in
- to develop novel targeted nanomedicine-based treatment concepts that are tested in cell lines and preclinical cancer models
Related research groups
Research group Human papillomaviruses (HPV)
Willem Melchers' research aims to improve the nationwide cervical cancer screening, with the possibility of using self sampling. Important herein is research on the use of new triage methods for hrHPV positive women, by using HPV genotyping or molecular biomarkers.read more
Radboudumc Technology Center Animal research facility
This technology center offers advice and support from planning up to and including the conduct of animal research on behalf of biomedical research and education.read more