News items related to the Department of Cell Biology.
p120-catenin-dependent collective brain infiltration by glioma cell networks7 January 2020
Pavlo Gritsenko and Peter Friedl, theme Cancer development and immune defense, report in Nature Cell Biology, that glioma cells infiltrate the brain by a collective network mechanism, which critically depends on p120 catenin. p120 thus represents a potential target to combat glioma.
A personal touch of Marieke Willemse10 December 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Marieke Willemse.
'Stofwisselkracht' grant for Paola de Haas and Alessandra Cambi5 December 2019
Paola de Haas and Alessandra Cambi, theme Nanomedicine, have recently been awarded a grant from ‘Stichting Stofwisselkracht’ for their project entitled “Identification of immune-related symptoms in Congenital Disorders of Glycosylation”.
Podosome nanoscale architecture redefined20 November 2019
Koen van den Dries and Alessandra Cambi, theme Nanomedicine, revealed how the nanoscale architecture of podosomes enables dendritic cells to protrude and sense their extracellular environment. They have published their results in Nature Communications.
Collective cancer invasion forms an integrin-dependent radioresistant niche29 October 2019
Anna Häger and Peter Friedl, theme Cancer development and immune defense, identified a new niche of cancer cell survival and developed an integrin inhibition therapy to overcome resistance. They have published their results in JEM.
Three VIDI grants for RIMLS researchers24 May 2019
Matthijs Jore, Daniele Tauriello and Johannes Textor are each to receive up to 800,000 euros to develop an innovative research theme and to build up their own research group. NWO is awarding the Vidi grant as part of the Innovational Research Incentives Scheme.
Cancer cell moves like a predator Lévy walk may be the weak spot of cancer cells19 November 2018
In contrast to their non-metastatic counterparts, metastatic cancer cells show movement patterns that are also often employed by predators searching for prey. This was shown by an international study on movement patterns of cancer cells published in Nature Communications.
Super-resolution correlative light and electron microscopy: Spotlight on the cells’ ultrastructure!28 August 2018
Researchers from the Dept. of Cell Biology, theme Nanomedicine, and the ‘Microscopy Imaging Center’ (MIC, a Radboudumc Technology Center), recently developed and optimized a pipeline for correlative imaging using super-resolution (SR) microscopy and scanning electron microscopy (SEM).
Microscopic imaging pierces the “black box” of cancer bone metastasis21 August 2018
Peter Friedl, theme Cancer development and immunce defense, and colleagues, have engineered a system allowing microscopic monitoring and imaging of cancer that has spread to the bone in mice so they can better understand and develop treatment for bone metastasis in humans.
Prinses Beatrix Spierfonds grant for Rick Wansink and Frank Walboomers23 July 2018
Rick Wansink, theme Nanomedicine, and Frank Walboomers, theme Reconstructive and regenerative medicine, have been awarded a 250.000 EUR grant of the Prinses Beatrix Spierfonds towards the study and elucidation of myotonic dystrophy, in a project entitled: Harmful RNA in myotonic dystrophy.