News

More variants TLR7 gene found in young healthy men with severe Covid-19 Screening and accelerated vaccination for TLR7 immunodeficiency

Spanish-Dutch research has revealed two new mutations in the TLR7 gene in healthy young men who became seriously ill with severe Covid-19.

Sonlicromanol seems promising for certain cancers Khondrion announces publication in PLOS ONE of new research

Khondrion announces publication in PLOS ONE of new research showing normalisation of prostate cancer stem cell mPGES-1 overexpression and inhibition of cancer spheroid growth by sonlicromanol’s active metabolite.

EM center on NPO2

On 21 April our EM center and the bone organoid that we created were featured in an episode of the science program Atlas (broadcasted on NPO2).

Current overview of intriguing RNA therapies

In an article in EMBO Molecular Medicine, researchers from Radboudumc, together with European colleagues, provide an up-to-date overview of the (im)possibilities of these intriguing RNA therapies.

First online FIJI course

Although Jack Fransen, Marieke Willemse and Merijn van Erp missed the personal classroom interactions, they can again look back to a successful course thanks to an enthusiastic group of 14 students who helped them through this first online version.

NWO open call GROOT grant for Peter Friedl

Peter Friedl, theme Cancer development and immune defense, received a 300,000 EUR grant within the NWO-GROOT consortium "Active matter of cancer metastasis" to identify the mechanisms of collective metastasis in breast cancer.

Prinses Beatrix Spierfonds grant to investigate patient stratification in myotonic dystrophy

RIMLS researchers Rick Wansink and Roland Brock, both theme Nanomedicine, received a € 280,000 grant from the Prinses Beatrix Spierfonds.

p120-catenin-dependent collective brain infiltration by glioma cell networks

Pavlo Gritsenko and Peter Friedl, theme Cancer development and immune defense, report in Nature Cell Biology, that glioma cells infiltrate the brain by a collective network mechanism, which critically depends on p120 catenin. p120 thus represents a potential target to combat glioma.

A personal touch of Marieke Willemse

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Marieke Willemse.

'Stofwisselkracht' grant for Paola de Haas and Alessandra Cambi

Paola de Haas and Alessandra Cambi, theme Nanomedicine, have recently been awarded a grant from ‘Stichting Stofwisselkracht’ for their project entitled “Identification of immune-related symptoms in Congenital Disorders of Glycosylation”.

Podosome nanoscale architecture redefined

Koen van den Dries and Alessandra Cambi, theme Nanomedicine, revealed how the nanoscale architecture of podosomes enables dendritic cells to protrude and sense their extracellular environment. They have published their results in Nature Communications.

Collective cancer invasion forms an integrin-dependent radioresistant niche

Anna Häger and Peter Friedl, theme Cancer development and immune defense, identified a new niche of cancer cell survival and developed an integrin inhibition therapy to overcome resistance. They have published their results in JEM.

A personal touch of Lise Ripken

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Lise Ripken.

MMD Lecturer of the year award for Alessandra Cambi

At their annual MMD symposium, Alessandra Cambi, theme Nanomedicine, was chosen as lecturer of the year 2018-2019 of the Top Master "Molecular mechanisms of disease". 

Retirement of Huib Croes

After a long working life of 35 years at the Department of Cell Biology, now a well-deserved retirement. Thank you Huib Croes!

Patient trust and participation in cell biological research

Alessandra Cambi and Gert Olthuis discuss key ethical issues inherent in the development and the value of building trust and trustworthiness.

A personal touch of Huib Croes

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Huib Croes.

A warm welcome for Hypatia fellow Daniele Tauriello

It is our pleasure to welcome a new research group leader and Hypatia fellow at RIMLS: Daniele Tauriello (dept Cell Biology).

Three VIDI grants for RIMLS researchers

Matthijs Jore, Daniele Tauriello and Johannes Textor are each to receive up to 800,000 euros to develop an innovative research theme and to build up their own research group. NWO is awarding the Vidi grant as part of the Innovational Research Incentives Scheme.

Final scientific pitch competition Radboud Talks

The finalists of the scientific pitch competition Radboud Talks have been selected. On Monday evening 25 March, eight scientists will compete in LUX for the award.

Research Integrity Round College Tour

Starring Alessandra Cambi, Judith Prins and Edo Richard. Your host on Monday 11 March is Pim Assendelft.

Peter Friedl is recognized as reviewer of the month

The editors of Communications Biology recognize Peter Friedl, theme Cancer development and immune defense, as reviewer of the month for his exceptional contributions to peer review.

Radium 223-mediated zonal cytotoxicity of prostate cancer in bone

Peter Friedl, theme Cancer development and immune defense, and colleagues published in the Journal of National Cancer Institute about the prevention of early bone cancer.

RIMLS awards festival Twelve winners

In 5 categories RIMLS young researchers received an award and bonus during the New Year's drinks. See all photo's.

Cancer cell moves like a predator Lévy walk may be the weak spot of cancer cells

In contrast to their non-metastatic counterparts, metastatic cancer cells show movement patterns that are also often employed by predators searching for prey. This was shown by an international study on movement patterns of cancer cells published in Nature Communications.

TURBO grants for four medical-technical research projects

Four TURBO grants were awarded to new technical-medical research proposals. The grants are part of the TURBO program, a collaboration between Radboudumc and the University of Twente.

Why animal research is still needed

Documentary on Dutch National TV with contributions from Otto Boerman and Peter Friedl.

Putting bone metastasis in the spotlight

In this 3D cross-section, you see the nuclei (green) and cytoplasm (red) of human prostate cancer cells growing inside a bioengineered construct of mouse bone (blue-green) that’s been placed in a mouse.

Super-resolution correlative light and electron microscopy: Spotlight on the cells’ ultrastructure!

Researchers from the Dept. of Cell Biology, theme Nanomedicine, and the ‘Microscopy Imaging Center’ (MIC, a Radboudumc Technology Center), recently developed and optimized a pipeline for correlative imaging using super-resolution (SR) microscopy and scanning electron microscopy (SEM).

Microscopic imaging pierces the “black box” of cancer bone metastasis

Peter Friedl, theme Cancer development and immunce defense, and colleagues, have engineered a system allowing microscopic monitoring and imaging of cancer that has spread to the bone in mice so they can better understand and develop treatment for bone metastasis in humans.

Prinses Beatrix Spierfonds grant for Rick Wansink and Frank Walboomers

Rick Wansink, theme Nanomedicine, and Frank Walboomers, theme Reconstructive and regenerative medicine, have been awarded a 250.000 EUR grant of the Prinses Beatrix Spierfonds towards the study and elucidation of myotonic dystrophy, in a project entitled: Harmful RNA in myotonic dystrophy.

Celebrations to mark the retirement of Bé Wieringa

With a great symposium entiteld “Journey of a lifetime” and valedictory lecture “t grote niet weerd" Bé Wieringa, a passionate researcher and pioneer of the RIMLS (NCMLS), said farewell.

Valedictory lecture of Bé Wieringa on 1 June

On the occasion of the retirement of Bé Wieringa a farewell symposium and valedictory lecture will be organized.

A personal touch of Paola de Haas

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Paola de Haas.

The interplay between migrating cells and tissue mechanics

Reviewed in Nature cell biology.

In remembrance: Jan Schepens

Oxygen deficiency causes tumors to change strategy

Hypoxia causes tumors to prune branches

Publication in Molecular Therapy

Cutting edge gene editing strategy for myotonic dystrophy