News items related to the Department of Molecular and Biomolecular Informatics.
Front cover Human Mutation21 August 2019
The MetaDome web server build to interpret genetic variants based on genetic tolerance and homologous protein domains is featured on the Cover of Human Mutation. MetaDome was developed by Laurens van de Wiel, Coos Baakman, Daan Gilissen, Joris Veltman, Gert Vriend and Christian Gilissen,
Valentine’s day spectacle at the Radboud Research Rounds21 February 2019
This year’s Valentine’s day in the Radboudumc was focused on the RRR of the Tumors of the Digestive Tract. In the biannual Paper Award session the big prize went to Daniel Garza from the Center for Molecular and Biomolecular Informatics, for his paper on “the environmental metabolome”.
Nature Methods paper on GPCR structure determination5 February 2019
The most recent addition to the GPCR database is a web tool to make the design of crystal constructs easier. CMBI Master's student Janne Bibbe was part of this project, and is now co-author of the paper "An online resource for GPCR structure determination and analysis" in Nature Methods.
COPAL reveals remodeling of mitochondrial protein complexes in Barth syndrome21 January 2019
Martijn Huijnen, theme Mitochondrial diseases, and colleagues developed COmplexome Profiling ALignment (COPAL) to systematically asses the effect of Barth syndome on mitochondrial protein complexes. They published their findings in Bioinformatics.
Five RIMLS researchers in top 1 percent by citations13 December 2018
Bas Dutilh, Leo Joosten, Jos van der Meer, Mihai Netea and Henk Stunnenberg made it to this year’s list of highly cited researchers. Researchers in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.
Minister pleads for a better use of big data in healthcare6 December 2018
The minister for medical care and sport, Bruno Bruins, sent his recommendation regarding the use of big data in healthcare to the House of Representatives. In order to securely share data, the Personal Health Train project was established. Peter-Bram ‘t Hoen is one of the project leaders.
Predicting metabolites based on bacterial genes19 March 2018
What do the bacteria eat, that live on your skin? Scientists at Radboudumc and Utrecht University have developed a novel computer model to answer this question, revealing that a lot of the food for skin bacteria is derived from beauty and skin care products.
Publication in Human Mutation Using homologous relationships of protein domains in the human genome to interpret genetic variation4 September 2017
This publication is part of the PhD project of Laurens van de Wiel and shows how homologous protein domain relations may be used to interpret normal and pathogenic variation at a much finer scale than previously possible.