Jo Zhou's group aims to establish disease models using patient material and model organisms to identify regulatory networks and disease mechanisms in developmental disorders. Using genomics technology, we map the genome-wide atlas of disease-associated regulatory elements beyond the coding regions.
Drosophila models of brain disorders and neurogenetics
Annette Schenck's research focuses on dissecting molecular networks and mechanisms underlying human brain function and disease. In order to be able to investigate the large number of genes, we use a powerful genetic model organism, the fruitfly Drosophila melanogaster.
Gene regulatory network models for brain disorders
Kees Albers's research group is focused on the integration of computational and experimental approaches to understand how genetic variation causes disease. In particular we try to understand how dysregulation of gene expression may cause disorders of the brain.
Genomic technologies & immuno-genomics
Alexander Hoischen's group focuses on the application of latest genomic technologies to understand human disease. A particular emphasis is put in the understanding of genetic defects that explain immune diseases, in particular primary immunodeficiencies (PIDs).
Usher syndrome: Genetics and functional genomics
Hannie Kremer's group aims to identify genetic defects that underlie hereditary hearing impairment and to unravel the molecular pathogenesis. Identification of deafness genes provides knowledge on inner ear function. Furthermore, it will provide handles for the development of future therapy.