Research Departments Physiology 20210602 PhD degree Lisanne Gommers
2 June 2021

Lisanne Gommers successfully defended her thesis entitled "Digesting the role of the gut microbiome in proton pump inhibitor (PPI)-induced hypomagnesemia".

Outline of this thesis
Patients with heartburn-related symptoms are often prescribed the antacid omeprazole. 10-20% of these patients develop a magnesium deficiency with long-term use. This manifests itself in muscle cramps, fatigue and palpitations. The underlying mechanism of these side effects is unknown. In mice, we show that a low intake of magnesium and disturbances in the gut microbiome are both risk factors for the development of magnesium deficiency with omeprazole use. These risk factors should be brought to the attention of physicians who prescribe antacids. The gut microbiome is essential in the digestion of fibers found in food. The breakdown of these fibers produces the fatty acid butyrate. We have shown that butyrate regulates the absorption of magnesium through TRPM7 channels in intestinal cells. Our study shows that additional dietary fiber, in combination with magnesium supplements, could be used as a future treatment for magnesium deficiency when using proton pump inhibitors.

Lisanne Gommers (1993) obtained her master's degree in Molecular Mechanisms of Disease (MMD) cum laude in 2016 from the Radboud Institute for Molecular Life Sciences (RIMLS), Radboudumc in Nijmegen. She conducted the above research at the Department of Physiology, Radboudumc, within the RIMLS. She is currently working as a consultant at the Department of Process Improvement & Implementation (PVI) of the Radboudumc at Nijmegen.

Click here to access Lisanne’ s thesis digitally.

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