Research Departments Physiology 20221005 PhD degree Gijs Franken

5 October 2022

Gijs Franken successfully defended his thesis entitled 'On the origin and function of renal magnesium transport'.

Outline of this thesis
Magnesium is an important mineral that plays a crucial role in many biological processes, required for normal physiology, such as muscle contraction, blood pressure regulation, and neurotransduction. Deficits in Mg may lead to fatigue, muscle cramp, epilepsy, and cardiac arrest. The kidneys play a central role in maintaining blood Mg levels constant. Within the kidney, the distal convoluted tubule (DCT) fine tunes Mg homeostasis as it regulates transcellular Mg transport. From the urine, Mg is reabsorbed via TRPM6/7 Mg channels. However, the exit route for Mg towards the blood remains unclear. Within my doctoral research, we have studied the proteins CNNM2 and SLC41A3 and their part in basolateral Mg transport. Using patient-data, animal models and biochemical approaches, we further characterised these proteins in vitro and in vivo, showing their indispensable role in Mg homeostasis. 

Biografy
Gijs Franken (1993) obtained his master’s degree in Molecular Mechanisms of Disease (MMD) cum laude in 2017 from the Radboud Institute for Molecular Life Sciences (RIMLS), Radboudumc in Nijmegen. He conducted his doctoral research at the Department of Physiology, Radboudumc, within the RIMLS. He is currently working as a lecturer at the Department of Physiology, Radboudumc.

Related news items


PhD degree for Marlou-Floor Kenkhuis

22 November 2022

Marlou-Floor Kenkhuis obtained her PhD degree in the Faculty of Health, Medicine and Life Sciences at the Maastricht University.

read more

Inaugural lecture Dick Thijssen

18 November 2022

In the Aula from the Radboud University Dick Thijssen gave his professorial lecture titled 'Stilstand is achteruitgang'. 

read more

International Cerebrovascular Research meeting CARNet

31 October 2022

Together with his co-promotor Jurgen Claassen and 3 students from the the department of Geriatric Medicine, Ralf Weijs, PhD at the Integrative Physiology group represented the Radboudumc.

read more

Joost Hoenderop research domain leader Discovery Science and BioMedTech

12 October 2022

In the new Reserach Institute, there will be a few new positions and roles. We are excited to announce that Joost Hoenderop has now been appointed as reserach domain leader Discovery Science and BioMedTech.

read more

Introduction of Arthur Willemsen Managing director

2 October 2022

Arthur Willemsen started has managing director/'bedrijfsleider' of the new Biomedical Science Department (BMS). Here he introduces himself.

read more

FIGHT-CNNM2 consortium meeting

29 September 2022

The second FIGHT-CNNM2 consortium meeting took place in Montreal (Canada), and was hosted by the research group of Michel Tremblay. 

read more