The group of Dr. Ayal Hendel works on the improvement of the CRISPR-Cas9 genome editing technology as a mean of genetic disorder therapy, by increasing the robustness and specificity of the method, to allow its use in clinical settings. His team primarily focuses on correcting mutations in hematopoietic genetic disorders as well as on improving the current immune therapies for fighting cancer through modification of T-cell receptors.
The group of Prof. Hans Clevers uses the technology of adult stem cell-based organoids to recapitulate and study tissue physiology as well as pathological processes. The main aim of his work is to employ patient-derived organoids and genome editing technologies to pave the way for precision medicine. Moreover, Prof. Clevers was the first one to identify stem cells in the adult intestine.
Prof. Alison Noble's main research interest is in biomedical image analysis, by integrating multiple scientific fields from device design to image analysis. Her current research is focused oin the development and application of machine learning tools for improvement of 2D, 3D and video ultrasound analysis, driven by the unmet needs of clinical research in this field.
Prof. Jan Huisken’s main research interest is in the advancement of non-invasive light sheet microscopy for the systematic study of early development in major model organisms, with the ultimate goal of understanding and describing tissue dynamics on the cellular level. His group primarily investigates organogenesis in zebrafish, with a particular focus on the morphogenesis of the cardiovascular system and endoderm.
Fundamental researchAntoine Coulon
Dr. Coulon focuses his research on understanding the spatio-temporal organization and dynamics that link the nuclear genome and the gene expression regulation. His group combines state of the art single-molecule imaging, physical/mathematical analysis and modeling techniques. His team’s most recent endeavour has been the development of techniques to visualize transcription in 4D in human cells.
The group of Prof. Francesca Ciccarelli uses systems biology approaches and large datasets to uncover new cancer genes and their genetic networks in the context of tumor onset, progression and evolution. Her studies aim at identifying unique aspects of cancer vulnerability through the analysis of the perturbed cancer networks in order to develop novel therapeutic approaches.
The group of Dr. Lundberg focuses on spatial proteomics and cell biology using bioimaging and proteomics to understand how protein localization varies among cell types and how it changes in health and disease. Her laboratory also engages the wider public through Citizen Science projects integrated into globally played online games and data scientists challenges. Dr. Lundberg was also recognized as one of the Top 10 scientists under 40 by GEN.