Research theme Disorders of movement


Disorders of movement About theme

Disorders of movement are common in patients with neurological abnormalities in the central or peripheral nervous system. A deeper understanding of these aberrations will help to improve and individualize the diagnostic, prognostic and therapeutic strategies for these patients.

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Disorders of movement About theme

The emphasis of the research in this theme lies on understanding the behavioral characteristics, the underlying pathophysiology and the associated neuroplasticity.

The theme focuses on three areas:
  • Neurodegenerative disorders –both Parkinson’s disease and hereditary forms- ,
  • (Congenital) neuromuscular disorders
  • Neurovascular disorders

Objectives

  • We will deepen our understanding of the nature and sources of variability in the clinical presentation of neurological patients presenting with disorders of movement. This includes a focus on environmental, behavioral and genetic determinants.
  • We will develop and evaluate improved strategies aiming to establish timely diagnostic and prognostic evaluation of neurological patients presenting with disorders of movement.
  • We aim to gain a better insight into the pathophysiological processes in the central and peripheral nervous system that lead to the clinical expression of disorders of movement. To achieve this aim, we will focus on both primary dysfunction and compensatory mechanisms as a basis for the future development of improved treatment strategies. Methods include state-of-the-art electrophysiology, biomechanics, structural and functional neuro-imaging and neurochemistry. A specific area of interest includes disorders of axial mobility.
  • We will develop and evaluate new treatment strategies for neurological patients presenting with disorders of movement, including a focus on behavioral and self-management strategies. A specific new area relates to deep brain stimulation techniques, both as a novel treatment strategy and as an exploratory research tool for examining cerebral dysfunctions underlying disorders of movement.
  • We will implement and develop an evidence basis for integrated care models for neurological patients presenting with disorders of movement, including a focus on allied health interventions and on innovative financial reimbursement systems.
  • We endeavor to develop and evaluate personalized “precision” medicines for neurological patients presenting with disorders of movement.

Theme leader

Full professor
prof.dr. Bas Bloem
+31 (0)24 361 52 02

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Perception, Action and Control Theme Donders

The Disorders of movement theme is closely integrated with the Donders Institute's theme Perception, Action and Control.

Perception, Action and Control

Our investigators

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