SYstematic Review Center for Laboratory animal Experimentation SYRCLE
SYRCLE’s aim is to promote the concept of systematic reviews of animal studies (SRs) in research. SRs contribute to more evidence-based choice of animal models, the implementation of the 3Rs and better patient safety.see video
Support and coaching
SYRCLE can provide coaching in the conduct of a systematic review of animal studies. The support can involve both face to face meetings or discussions via telephone, SKYPE or email. Support can include:
- Help with formulating a suitable and specific research question
- Advice on how to fill out the protocol for your review
- Feedback on the PubMed search strategy you have developed
- Help with translating it into a strategy for e.g. Embase
- Assistance in formulating inclusion and exclusion criteria and the criteria for the risk of bias assessment
- Advice on whether it is possible to perform a meta-analysis and, if so, which type of meta-analysis
Tools and guidelines
0. Starting guideThis tool provides practical guidance in how to design, plan and conduct your own systematic reviews (and meta-analysis) of animal studies. It is largely based on the experience we obtained at SYRCLE over the last 10 years in our own reseach and supervising systematic reviews of animal studies.
N.B. We recommend training and coaching by an expert when conducting your first SR of animal studies.
1. ProtocolA protocol format for the preparation, registration and publication of systematic reviews of animal intervention studies. Read full text paper.
Fillable protocol format (MS Word)
2. SearchSYRCLE had developed various search tools for finding all relevant primary animal studies.
2.1 Step by step Search guide
A practical Step by step search guide for finding relevant primary studies. Read full text paper.
2.2 Search filters
- To incorporated filter in PubMed
- Text to copy and paste filter
- Text to copy and paste filter
3. Risk of Bias assessmentA tool by SYRCLE for assessing the risk of bias of animal intervention studies. Read full text paper.
SYRCLE’s RoB tool
4. Meta-analysisAn introduction
A practical guide
Individuals and/or departments from all over the world support SYRCLE in promoting systematic reviews: our so-called ambassadors. Please feel free to contact your local SYRCLE-ambassador when you want to know more about systematic reviews or animal studies.
If you like to be a SYRCLE ambassador, please contact us.
Meer kennis, minder dieren, ZonMw,
Lucianne GroeninkUtrecht University
Faculty of Science, Department of Pharmaceutical Sciences
Utrecht Institute for Pharmaceutical Sciences (website)
Division Pharmacology Department of Pharmacology and Personalised Medicine, Maastricht University
Jan WoltersLaboratory Animals, Academisch Medisch Centrum
Cursus Proefdierkunde voor Onderzoekers Amsterdam
Norway: Aurora BronstadDreavdelingen/The animal facility, Department of Clinical Medicine, University of Bergen, Norway
Sweden: Rafael FriasDirector, LAS Education & Training Unit
Comparative Medicine Karolinska Institutet
Denmark: Birgitte KousholtDepartment of Clinical Medicine Faculty of Health
Aarhus University, Denmark
Birgitte Kouholt website
UK (Scotland): Emily SenaCAMARADES, Centre for Clinical Brain Sciences, University of Edinburgh (website)
UK: Nikki OsborneResponsible Research in Practice, West Sussex, UK
Swiss: Maike HeimannETH Zürich, Administrative Departement Safety, Security, Health and Environment, Education in lab animal science
Spain: Patri VergaraUnitat de Fisiologia Animal Departament de Biologia Cellular, Fisiologia i Immunologia Facultat de Veterinaria Universitat Autonoma de Barcelona
Canada: Marc AveyOttawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada AND Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
India: Vijay Pal SinghCSIR-Institute of Genomics & Integrative Biology
Academy of Scientific and Innovative Research
Australia: Brett LidburyPattern Recognition & Pathology
The John Curtin School of Medical Research,
Department of Genome Sciences
College of Medicine, Biology & Environment
The Australian National University
Brazil: Monica Levy AndersenAssociate Professor and Chief of Sleep Division – Department of Psychobiology – Federal University of São Paulo (UNIFESP)
Coordinator – National Council for Control of Animal Experimentation, Brazil
Brazil: Gabriel Natan PiresAssociate Researcher – Department of Psychobiology – Federal University of São Paulo (UNIFESP)