SYstematic Review Center for Laboratory animal Experimentation SYRCLE

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SYstematic Review Center for Laboratory animal Experimentation SYRCLE


SYstematic Review Center for Laboratory animal Experimentation SYRCLE

SYRCLE’s aim is to promote the concept of systematic reviews of animal studies (SRs) in research. SRs contribute to more evidence-based choice of animal models, the implementation of the 3Rs and better patient safety.

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Contact

Prof. Merel Ritskes-Hoitinga PhD
+31 (0)24 361 07 09

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Support and coaching

SYRCLE can provide coaching in the conduct of a systematic review of animal studies. The support can involve both face to face meetings or discussions via telephone, SKYPE or email. Support can include:

  • Help with formulating a suitable and specific research question
  • Advice on how to fill out the protocol for your review
  • Feedback on the PubMed search strategy you have developed
  • Help with translating it into a strategy for e.g. Embase
  • Assistance in formulating inclusion and exclusion criteria and the criteria for the risk of bias assessment
  • Advice on whether it is possible to perform a meta-analysis and, if so, which type of meta-analysis
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Support and coaching

SYRCLE can provide coaching in the conduct of a systematic review of animal studies. The support can involve both face to face meetings or discussions via telephone, SKYPE or email. Support can include:
  • Help with formulating a suitable and specific research question
  • Advice on how to fill out the protocol for your review
  • Feedback on the PubMed search strategy you have developed
  • Help with translating it into a strategy for e.g. Embase
  • Assistance in formulating inclusion and exclusion criteria and the criteria for the risk of bias assessment
  • Advice on whether it is possible to perform a meta-analysis and, if so, which type of meta-analysis
Researchersaffiliated with Dutch research institutes can apply for funding at ZonMW.

Tools and guidelines

We offer tools and guidelines for the conduct of systematic reviews of animal studies.

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Tools and guidelines

0. Starting guide

This tool provides practical guidance in how to design, plan and conduct your own systematic reviews (and meta-analysis) of animal studies. It is largely based on the experience we obtained at SYRCLE over the last 10 years in our own reseach and supervising systematic reviews of animal studies. 
N.B. We recommend training and coaching by an expert when conducting your first SR of animal studies.

1. Protocol

A protocol format for the preparation, registration and publication of systematic reviews of animal intervention studies. Read full text paper.
Fillable protocol format (MS Word)

2. Search

SYRCLE had developed various search tools for finding all relevant primary animal studies.
2.1 Step by step Search guide
A practical Step by step search guide for finding relevant primary studies. Read full text paper.
2.2 Search filters
2.2.1 PubMed
- To incorporated filter in PubMed
- Text to copy and paste filter
2.2.2 Embase
- Text to copy and paste filter

3. Risk of Bias assessment

A tool by SYRCLE for assessing the risk of bias of animal intervention studies. Read full text paper.
SYRCLE’s RoB tool

4. Meta-analysis

An introduction
A practical guide

Newsletter

You can subscribe to our newsletter or read previous newsletters.

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Protocols

If you want to perform a systematic review yourself or publish a protocol please contact SYRCLE.

see published protocols

Protocols

syrcle@umcn.nl

If you want to perform a systematic review yourself or publish a protocol please contact SYRCLE.



SYRCLE ambassadors

Individuals and/or departments from all over the world support SYRCLE in promoting systematic reviews: our so-called ambassadors. Please feel free to contact your local SYRCLE-ambassador when you want to know more about systematic reviews or animal studies.

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SYRCLE ambassadors

syrcle@umcn.nl

Individuals and/or departments from all over the world support SYRCLE in promoting systematic reviews: our so-called ambassadors. Please feel free to contact your local SYRCLE-ambassador when you want to know more about systematic reviews or animal studies.

If you like to be a SYRCLE ambassador, please contact us.



In-house workshop

Dutch research institutes can host an in-house workshop, contact us (syrcle@radboudumc.nl) for more information. Funding available via ZonMW.

more funding information

Prof. Merel Ritskes-Hoitinga PhD

+31 (0)24 361 07 09
full professor

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