En Research Themes Cancer development and immune defense

Cancer development and immune defense About theme

In order to improve the success of treatment and to further individualize such treatment, we need to gain a better understanding of the molecular,(epi)genetic and immunological processes that are implicated in the transformation of normal (stem) cells to malignant cancer cells.

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Cancer development and immune defense About theme

Annually, more than 100,000 people in the Netherlands, or one-third of the population, currently develop cancer at some point in their lives. About 40% of these patients will die within five years. For patients with a localized solid tumor, prospects are quite good, but for most patients with disseminated disease, unfortunately, prognosis is still poor. This also holds for some hematological cancers. In order to improve the success of treatment and to further individualize such treatment, we need to gain a better understanding of the molecular,(epi)genetic and immunological processes that are implicated in the transformation of normal (stem) cells to malignant cancer cells.

We investigate therapy resistance, the tumor micro-environment, cancer cell trafficking and the interaction between the immune system and cancer. We translate this basic knowledge into novel forms of therapy targeting tumor cells. We also develop strategies to expand and manipulate immune cells for clinical use, exploiting and boosting the power of the immune system. For the translational part, we are directing phase I, II and III clinical trials.

Objectives

  • We aim to identify all genetic ‘driver’ lesions that underlie the pathogenesis of cancer.
  • We study epigenetic mechanisms implicated in aberrant gene expression in cancer.
  • We study immune cell and cancer cell trafficking.
  • We investigate to what extent the immune system is capable of recognizing tumor cells.
  • We study mechanisms to stimulate specific anti-tumor immune responses.
  • We will perform clinical trials to test compounds that specifically target the molecular pathways that are disturbed.
  • We will perform clinical trials in which manipulated immune cells are used to eradicate cancer cells.
  • We direct prospective, population-based cancer registries to analyze prognosis, therapy response, quality of life and economic aspects.

Theme leader

Joop Jansen PhD
full professor

+31 (0)24 361 03 72

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Societal impact

More information will follow soon.

News and agenda

Organisation


Researchers Cancer development and immune defense

See the researchers related to this theme.

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Answers in Dutch

Information on our research can also be found in Dutch on the Nationale Wetenschapsagenda website. The information here answers questions asked by Dutch citizens. Nationale Wetenschapsagenda

Research group leaders

Affiliated institutes and centers

Radboud Institute for Health Sciences

Ideally, every procedure in clinical practice and public health should take place based on proof, instead of intuition or 'experience'. Our aim is to improve clinical practice and public health. read more

Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes. read more
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