News - Radboudumc

Research Themes Cancer development and immune defense News

The following news items are related to the research Cancer development and immune defense.

Combinatorial transcription factor activities on open chromatin induce embryonic heterogeneity in vertebrates

9 February 2021

Gert-Jan Veenstra and Simon van Heeringen published in the Embo Journal. Their results show that transcription factors cooperate in a combinatorial fashion in generally open chromatin to orchestrate zygotic gene expression.

Predicting protein condensate formation using machine learning

4 February 2021

Guido van Mierlo, Jurriaan Jansen, Simon van Heeringen and Michiel Vermeulen and colleagues recently published in Cell Reports that predicting protein condensate formation can be done using machine learning.

RIMLS online award ceremony proudly presenting the winners

13 January 2021

In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony.

NWO ENW KLEIN grant awarded to Koen van den Dries and Michiel Vermeulen

22 December 2020

Koen van den Dries will investigate the molecular mechanisms of actin isoform usage in cancer cell migrations. Michiel Vermeulen will search for proteins that interact with adenosine diphosphate ribose chains and play a role in the cellular response to damage to DNA.

Radboudumc signs collaboration agreement to develop personalized diagnostics

16 December 2020

Radboudumc together with scientists from Erasmus MC has signed a license agreement with Sebia, world leader in multiple myeloma diagnostics.

Granted research projects 2020 by Hanarth Fonds

8 December 2020

The Hanarth Fonds finances research projects of Iris Nagtegaal and Johannes Textor that use artificial intelligence or machine learning to improve the diagnosis, treatment and outcome of patients with cancer.

Dynamic plasma membrane organization a complex symphony

8 December 2020

Sjoerd van Deventer, Abbey Arp and Annemiek van Spriel, published in Trends in cell biology that a dynamic plasma membrane organization is a complex symphony.

Controlled human malaria infection induces long-term functional changes in monocytes

3 December 2020

Robert Sauerwein and Henk Stunnenberg together with Mihai Netea and other colleagues now show for the first time that even a parasitic infection can train the immune system. The article is published in Frontiers in Molecular Biosciences.

NWO XS awarded to identify X inactivation proteins

24 November 2020

NWO XS awarded to the lab of Hendrik Marks for identification of proteins that inactivate the female X chromosome.

Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation

28 October 2020

A multidisciplinary team of RIMLS and Radboud University researchers published in Advanced Science that Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation.

The Metastatic Microbiome rewarded with a Dutch Cancer Society Grant

24 September 2020

Annemarie Boleij, Iris Nagtegaal & Daniele Tauriello received the Dutch Cancer Society (KWF) Grant to explore the role of bacteria on colorectal cancer metastasis.

Dutch Cancer Society Grant received by Annemiek van Spriel and Laia Querol-Cano

23 September 2020

Annemiek van Spriel and Laia Querol-Cano received a Dutch Cancer Society Grant of 700K euros to study the cancer cell surface in immunotherapy.

Tumor cells stimulate lipid biosynthesis in macrophages

23 September 2020

RIMLS researchers wrote in the Journal for ImmunoTherapy of Cancer that improved lipid biosynthesis in human tumor-induced macrophages contributes to their protumoral characteristics.

Research into systemic anti-psoriasis therapies in patients aged 65+ Age alone should not be a limiting factor in treatment

27 August 2020

Much research has been done on the effectiveness and safety of systemic antipsoriasis therapies in general, but the effectiveness in specifically older adults psoriasis patients has never been systematically assessed.

Tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

26 August 2020

Carl Figdor and colleagues showed in Nature Communications that the tumour microenvironment (TME) forms a major obstacle in effective cancer treatment and for clinical success of immunotherapy.

Interference transitions in case of invasion of breast cancer determined by cell-cell adhesion and 3D matrix confinement

25 August 2020

Peter Friedl and colleagues, theme Cancer development and immune defence, published in Nature Cell Biology (NCB) the mechanisms of jamming and unjamming transitions of mammary carcinoma invasion along tossue microtracks.

Collective invasion induced by autocrine purinergic loop through connexin-43 hemichannels

13 August 2020

Peter Friedl, Paul Span and Antoine Khalil show in Journal of Cell Biology that breastcancer cells release purines into the extracellular space via connexin-43 hemichannels to control collective invasion.

TP53 allelic state is critical for diagnostic and prognostic precision in blood cancer

12 August 2020

An international study, in which Joop Jansen participated, shows that a double mutaton in TP53 gene deteriotes the prognosis of a rare form of blood cancer. If there is only one mutation or no mutation, then the prognosis is better.

Software for ranking protein-protein interfaces Released by eScience Center

10 July 2020

Li Xue of the CMBI contributed to the development of a software package that ranks and scores protein-protein interfaces (PPIs). This article was published in Software X.

New pluripotent state discovered during mouse embryonic development

11 May 2020

In a joined effort with ErasmusMC, the team of Hendrik Marks identified an exciting new "rosette" state of pluripotency dependent of WNT and MEK signaling as reported in Nature Cell Biology.

HFSP Grant for Johannes Textor

30 March 2020

Johannes Textor, theme Cancer development and immune defense, has been awarded a program grant of 1 million US dollars by The Human Frontier Science Program (HFSP) to investigate how T cells navigate extremely dense environments using experiments, modeling and methods from pedestrian dynamics.

Guiding the surgeon real-time tumor visualization during surgery

26 February 2020

Incomplete excision of tumor tissue negatively affects the prognosis of the patient. RIHS researcher Mark Rijpkema and colleagues are working on the development of new dual-labeled tracers and currently are implementing this into the clinic.

NWO open call GROOT grant for Michiel Vermeulen

24 February 2020

Michiel Vermeulen, theme Cancer development and immune defense, received a 300,000 EUR grant within the NWO-GROOT consortium. He will use mass spectrometry-based proteomics and interaction proteomics applications to study proteome and gene expression dynamics during early C. Elegans development.

NWO open call GROOT grant for Peter Friedl

24 February 2020

Peter Friedl, theme Cancer development and immune defense, received a 300,000 EUR grant within the NWO-GROOT consortium "Active matter of cancer metastasis" to identify the mechanisms of collective metastasis in breast cancer.

Human pDCs attract cytolytic lymphocytes in anti-cancer vaccination

6 February 2020

RIMLS researchers Jasper van Beek and Jolanda de Vries, theme Cancer development and immune defense, discovered that pDCs can efficiently recruit cytolytic immune effector cells, a property that could be exploited in anti-cancer vaccines. They have published these findings in Cell Reports.

ZonMw funding for teams of Michiel Vermeulen and Jolanda de Vries

4 February 2020

The awarded research projects of RIMLS researchers Michiel Vermeulen, Jolanda de Vries, Gerty Schreibelt and Martijn Verdoes and colleagues will initiate new research lines and collaborations between various research groups.

RIMLS PhD retreat registration is open

23 January 2020

Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.

p120-catenin-dependent collective brain infiltration by glioma cell networks

7 January 2020

Pavlo Gritsenko and Peter Friedl, theme Cancer development and immune defense, report in Nature Cell Biology, that glioma cells infiltrate the brain by a collective network mechanism, which critically depends on p120 catenin. p120 thus represents a potential target to combat glioma.

Niels Stensen Fellowship for Jorieke Weiden

6 January 2020

Jorieke Weiden was recently awarded a grant from the Niels Stensen Fellowship. Since the 1960s, the Niels Stensen Fellowship has been awarded annually to outstanding researchers who recently received their PhD to enable them to gain research experience at a top university or institute abroad.

Galectin-9 controls plasma membrane integrity of dendritic cells

16 December 2019

Laia Querol Cano, theme Cancer development and immune defense, has discovered how galectin-9, a sugar-binding membrane organiser, governs dendritic cell function by intracellularly modulating actin cytoskeleton. These findings are published in the latest issue of iScience.

New insights into the initiation of T cell responses in the spleen

11 December 2019

Carl Figdor and colleagues, theme Cancer development and immune defense, provide insights into the initiation of T cell responses in the spleen and their consequences for T cell differentiation. They have published their results in Proceedings of the National Academy of Sciences USA.

Two teams of RIMLS participate in Alpe d'HuZes

10 December 2019

Sixteen employees of our FNWI group have taken on the challenge to run, bike or hike up the mountain Alpe d’Huez as many times as possible on 4 June 2020, to raise as funding for cancer research.

Exploration meeting Academic Alliance on Oncology

2 December 2019

Within the Academic Alliance, the Maastricht UMC+ and Radboudumc are already working together in several areas. And this is happening in more and more fields. On 27 November researchers from both umc's met during the fourth Exploration meeting, this time with the theme: Oncology.

Five RIMLS researchers in top 1 percent by citations

26 November 2019

Leo Joosten, Jos van der Meer, Mihai Netea, Henk Stunnenberg and Frank van de Veerdonk, made it to this year’s list of highly cited researchers. Researchers in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.

RIMLS awards call for nominations

26 November 2019

RIMLS awards several prizes to stimulate and honor our (young) researchers. Please find here an overview of the upcoming awards. Deadline 12 December 2019.

Collective cancer invasion forms an integrin-dependent radioresistant niche

29 October 2019

Anna Häger and Peter Friedl, theme Cancer development and immune defense, identified a new niche of cancer cell survival and developed an integrin inhibition therapy to overcome resistance. They have published their results in JEM.

Algorithm to predict which cancer patients benefit from immunotherapy

29 October 2019

Rik Lindeboom and Michiel Vermeulen, theme Cancer development and immune defense, have developed an algorithm that can predict which cancer patients are more likely to benefit from immunotherapy. This new technology’s potential is described in Nature Genetics.

KWF Roadshow 11 November 2019

10 October 2019

In which way(s) can KWF provide optimal support to oncological research and care? How can we maximize impact on our investments? These questions are pivotal in Ambition 2030: the vision that KWF developed in close cooperation with stakeholders in the oncological field.

Jubilee lecture and symposium Carl Figdor

3 October 2019

For Carl Figdor, theme Cancer development and immune defense, who has been active in the field of tumor immunology for 40 years, a jubilee lecture and symposium will be organised.

RIMLS 25 years jubilee festival The Future is Yesterday

3 October 2019

Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...

'Radboudpluim' for Jeanette Pots

12 September 2019

Jeanette Pots received the 'Radboudpluim' from Paul Smits, for her exceptional services as technician at the department of Tumor Immunology.

RIMLS PhD grants awarded to eight RIMLS (j)PI's

12 September 2019

Recently, RIMLS held an internal call for Radboudumc junior researcher (PhD) positions. Congratulations for all the awardees and all the best in conducting the research projects.

A personal touch of Lenneke Cornelissen

5 September 2019

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Lenneke Cornelissen.

New technique boosts preclinical antibody research

30 August 2019

Martijn Verdoes, theme Nanomedicine, and Bas van der Schoot, theme Cancer development and immune defense, developed a technique to engineer and produce antibodies quickly, easily and cheaply. The researchers published their results in the open access journal Science Advances.

Publication in Blood on CD37 mutations in lymphoma

26 August 2019

Suraya Elfrink, in Annemiek van Spriel's research group Immune cell signaling, theme Cancer development and immune defense, published a manuscript in Blood reporting that tetraspanin CD37 is frequently mutated in patients with diffuse large B cell lymphoma occurring at immune-privileged sites.

Front cover Human Mutation

21 August 2019

The MetaDome web server build to interpret genetic variants based on genetic tolerance and homologous protein domains is featured on the Cover of Human Mutation. MetaDome was developed by Laurens van de Wiel, Coos Baakman, Daan Gilissen, Joris Veltman, Gert Vriend and Christian Gilissen,

Nicoline Hoogerbrugge and Michiel Vermeulen newly elected in Academia Europaea

26 July 2019

The Academia Europaea is a functioning European Academy of Humanities, Letters and Sciences, composed of individual members.

Dutch National Research Agenda - Idea Generator grant for Harry Dolstra and Paul de Jonge

15 July 2019

Paul de Jonge and Harry Dolstra, theme Cancer development and immune defense, received a €50.000,- (NWA-IDG) grant for their project regarding cancer immunotherapy.

Awarded KWF grants for Radboudumc researchers

2 July 2019

The Dutch Cancer Society (KWF) has awarded 25.5 million euros to 50 new research projects in 16 different institutes. 8 grants are awarded to Radboudumc researchers. We congratulate our researchers with this funding and wish them success with their great work.

A personal touch of Jeroen Creemers

27 June 2019

Filter results