A single protein complex balances the very first lineage decision of cells in human: towards foetus or placenta21 June 2022
The international group of researchers spearheaded by Dick Zijlmans and Hendrik Marks together with colleagues from KU Leuven, examined which proteins are associated with the chromatin and how this affects gene transcription.
European grants for groundbreaking Radboudumc research Professors Roshan Cools and Peter Friedl receive ERC Advanced Grant26 April 2022
The European Research Council (ERC) is awarding grants to Roshan Cools and Peter Friedl, both professors at Radboudumc. While Cools will investigate how brains control behaviour in (stressful) situations, Friedl will work on developing a new cancer therapy.
Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation published in Cellular and Molecular Life Sciences20 April 2022
Lisa Huis in ‘t Veld, Nataschja Ho and colleagues from the team of Gosse Adema published in Cellular and Molecular Life Sciences that Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation.
ERC Proof of Concept Grant for Martijn Verdoes8 March 2022
Martijn Verdoes, group leader Chemical Immunology at the department of Tumor Immunology, has been awarded an ERC Proof of Concept (PoC) Grant. The ERC PoC Grants are designed to support ERC grantees with the commercial or societal application of the results of their funded research.
Hans Jacobs receives KWF Proof-of-Concept grant to develop personalized cancer diagnostics11 January 2022
The Dutch Cancer Society (KWF) launched a new funding program to support successful KWF researchers to translate their results into clinical practice. Hans Jacobs and his team developed a personalized blood-test to measure minimal residual disease (MRD) in patients with multiple myeloma.
New genetic defect links cell biology and protein glycosylation10 November 2021
Peter Linders, Dirk Lefeber and Geert van den Bogaart together with international colleagues have recently reported on novel cell biological insights, by identifying a genetic disorder in syntaxin-5 which allowed to unravel a new mechanism regulating intracellular transportation.
Sensitive blood-test as a patient-friendly alternative for bone marrow-based cancer monitoring20 October 2021
Hans Jacobs and Pieter Langerhorst, theme Cancer development and immune defense, and colleagues are one step closer to implementation of personalized diagnostics for bone marrow-based cancer monitoring.
Reading ADP-ribosylation signaling using chemical biology and interaction proteomics published in Molecular Cell22 September 2021
Kasia Kliza and Michiel Vermeulen worked on a project to synthesize biotinylated ADPr-based probes that can identify ADPr readers and determine their specificity for mono- and polyADPr. They published this in Molecular Cell.
Michiel Vermeulen and Klaas Mulder receive funding from ZonMw for a collaborative project using stem cell-based models15 July 2021
Michiel Vermeulen and Klaas Mulder, theme Cancer development and immune defense, receive funding from ZonMw for a collaborative project to develop a stem cell based model to study early human embryogenesis.
ZonMw Open Competition Grant for Annemiek van Spriel and Piet Gros15 June 2021
Annemiek van Spriel, theme cancer development and immune defense, together with Piet Gros, Dept. of Chemistry, Utrecht University obtained a ZonMw Open Competition Grant to investigate IL-6 receptor structure and signalling in tumor cells.
A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses8 June 2021
Jeroen Creemers and Johannes Textor published in the Journal for ImmunoTherapy of Cancer that a tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery.
Vaccination with immune cells boosts immune system after stem cell transplantation1 June 2021
Jesper van Eck van der Sluijs and other researchers have developed a method for growing different types of dendritic cells: the cells of the immune system that specialize in processing foreign substances (including tumor proteins) and presenting them to killer cells.
Miniaturized microfluidic platform for automated epigenetic profiling6 May 2021
Together with Fluidigm, a US-based company focusing on microfluidics, the team of Hendrik Marks publishes in Genome Research the development of a powerful plug and play ChIP-seq platform for minute amount of cells, such as embryonic specimens or small biopsies.
Combinatorial transcription factor activities on open chromatin induce embryonic heterogeneity in vertebrates9 February 2021
Gert-Jan Veenstra and Simon van Heeringen published in the Embo Journal. Their results show that transcription factors cooperate in a combinatorial fashion in generally open chromatin to orchestrate zygotic gene expression.
RIMLS online award ceremony proudly presenting the winners13 January 2021
In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony.
NWO ENW KLEIN grant awarded to Koen van den Dries and Michiel Vermeulen22 December 2020
Koen van den Dries will investigate the molecular mechanisms of actin isoform usage in cancer cell migrations. Michiel Vermeulen will search for proteins that interact with adenosine diphosphate ribose chains and play a role in the cellular response to damage to DNA.
Controlled human malaria infection induces long-term functional changes in monocytes3 December 2020
Robert Sauerwein and Henk Stunnenberg together with Mihai Netea and other colleagues now show for the first time that even a parasitic infection can train the immune system. The article is published in Frontiers in Molecular Biosciences.
Research into systemic anti-psoriasis therapies in patients aged 65+ Age alone should not be a limiting factor in treatment27 August 2020
Much research has been done on the effectiveness and safety of systemic antipsoriasis therapies in general, but the effectiveness in specifically older adults psoriasis patients has never been systematically assessed.
Tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture26 August 2020
Carl Figdor and colleagues showed in Nature Communications that the tumour microenvironment (TME) forms a major obstacle in effective cancer treatment and for clinical success of immunotherapy.
Interference transitions in case of invasion of breast cancer determined by cell-cell adhesion and 3D matrix confinement25 August 2020
Peter Friedl and colleagues, theme Cancer development and immune defence, published in Nature Cell Biology (NCB) the mechanisms of jamming and unjamming transitions of mammary carcinoma invasion along tossue microtracks.
Collective invasion induced by autocrine purinergic loop through connexin-43 hemichannels13 August 2020
Peter Friedl, Paul Span and Antoine Khalil show in Journal of Cell Biology that breastcancer cells release purines into the extracellular space via connexin-43 hemichannels to control collective invasion.
TP53 allelic state is critical for diagnostic and prognostic precision in blood cancer12 August 2020
An international study, in which Joop Jansen participated, shows that a double mutaton in TP53 gene deteriotes the prognosis of a rare form of blood cancer. If there is only one mutation or no mutation, then the prognosis is better.
HFSP Grant for Johannes Textor30 March 2020
Johannes Textor, theme Cancer development and immune defense, has been awarded a program grant of 1 million US dollars by The Human Frontier Science Program (HFSP) to investigate how T cells navigate extremely dense environments using experiments, modeling and methods from pedestrian dynamics.
Guiding the surgeon real-time tumor visualization during surgery26 February 2020
Incomplete excision of tumor tissue negatively affects the prognosis of the patient. RIHS researcher Mark Rijpkema and colleagues are working on the development of new dual-labeled tracers and currently are implementing this into the clinic.
NWO open call GROOT grant for Michiel Vermeulen24 February 2020
Michiel Vermeulen, theme Cancer development and immune defense, received a 300,000 EUR grant within the NWO-GROOT consortium. He will use mass spectrometry-based proteomics and interaction proteomics applications to study proteome and gene expression dynamics during early C. Elegans development.