News

Oncode collaboration: mobilizing innate leukocytes to attack tumors  Radboudumc is partner in a research project funded by KWF for 3.4 million euros

Hans Jacobs receives KWF Proof-of-Concept grant to develop personalized cancer diagnostics

The Dutch Cancer Society (KWF) launched a new funding program to support successful KWF researchers to translate their results into clinical practice. Hans Jacobs and his team developed a personalized blood-test to measure minimal residual disease (MRD) in patients with multiple myeloma.

Stressed tumor cell switches to power saving mode to metastasize

DeepRank: a deep learning framework for data mining 3D protein-protein interfaces

Li Xue and colleagues recently published ''DeepRank, a deep learning framework for data mining 3D protein-protein structures'' in Nature Communications.

Villa Joep Research Grant for Radiotherapy & OncoImmunology (ROI) lab

Renske van den Bijgaart and Gosse Adema from the Radiotherapy & OncoImmunology laboratorium in collaboration with the Prinses Maxima Center received a grant from Villa Joep of 410k Euro.

New genetic defect links cell biology and protein glycosylation

Peter Linders, Dirk Lefeber and Geert van den Bogaart together with international colleagues have recently reported on novel cell biological insights, by identifying a genetic disorder in syntaxin-5 which allowed to unravel a new mechanism regulating intracellular transportation.

Sensitive blood-test as a patient-friendly alternative for bone marrow-based cancer monitoring

Hans Jacobs and Pieter Langerhorst, theme Cancer development and immune defense, and colleagues are one step closer to implementation of personalized diagnostics for bone marrow-based cancer monitoring.

RIMLS awards call for nominations

RIMLS awards several prizes to stimulate and honor our (young) researchers. Upcoming awards are Supervisor of the Year, Best Master Thesis, Best Publication, Best Image and more. Send your nominations now before 24 November 2021.

Reading ADP-ribosylation signaling using chemical biology and interaction proteomics published in Molecular Cell

Kasia Kliza and Michiel Vermeulen worked on a project to synthesize biotinylated ADPr-based probes that can identify ADPr readers and determine their specificity for mono- and polyADPr. They published this in Molecular Cell.

Cooperating T cells clear tumor cells more effectively

Live imaging: immune cells attack tumor

Off the shelf proximity biotinylation for interaction proteomics

Irene Santos-Barriopedro and Michiel Vermeulen, theme Cancer development and immune defense, published an off-the-shelf proximity biotinylation enzyme for interaction proteomics.

Michiel Vermeulen and Klaas Mulder receive funding from ZonMw for a collaborative project using stem cell-based models

Michiel Vermeulen and Klaas Mulder, theme Cancer development and immune defense, receive funding from ZonMw for a collaborative project to develop a stem cell based model to study early human embryogenesis.

ZonMw funding for PSIDER program

Michiel Vermeulen, Klaas Mulder and Nael Nadif Kasri receive funding from ZonMw for a collaborative project to develop a stem cell based model to study early human embryogenesis.

Researchers identify missing ‘switch’ that controls expression of essential genes Published in Nature

Michiel Vermeulen and colleagues identified that a long-sought-after transcription factor that regulates essential genes in the mouse and human genome. Published in Nature.

New culture method reveals how cancer cells bypass immune system

Publication in Cancer Immunology Research

ZonMw Open Competition Grant for Annemiek van Spriel and Piet Gros

Annemiek van Spriel, theme cancer development and immune defense, together with Piet Gros, Dept. of Chemistry, Utrecht University obtained a ZonMw Open Competition Grant to investigate IL-6 receptor structure and signalling in tumor cells.

A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses

Jeroen Creemers and Johannes Textor published in the Journal for ImmunoTherapy of Cancer that a tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery.

Vaccination with immune cells boosts immune system after stem cell transplantation

Jesper van Eck van der Sluijs and other researchers have developed a method for growing different types of dendritic cells: the cells of the immune system that specialize in processing foreign substances (including tumor proteins) and presenting them to killer cells.

Miniaturized microfluidic platform for automated epigenetic profiling

Together with Fluidigm, a US-based company focusing on microfluidics, the team of Hendrik Marks publishes in Genome Research the development of a powerful plug and play ChIP-seq platform for minute amount of cells, such as embryonic specimens or small biopsies.

Same shades of gray but different protein compositions

Maaike van Bergen, theme Cancer development and immune defence, and co-workers published in Blood about specific proteome changes in platelets from individuals with certain bleeding disorders.

2.5 million Euros for cancer research into ovarian cancer and immunotherapy

The Radboudumc receives 2.5 million Euros from the Dutch Cancer Society (KWF) for three studies to ensure oncological progress during COVID-19 period.

Combinatorial transcription factor activities on open chromatin induce embryonic heterogeneity in vertebrates

Gert-Jan Veenstra and Simon van Heeringen published in the Embo Journal. Their results show that transcription factors cooperate in a combinatorial fashion in generally open chromatin to orchestrate zygotic gene expression.

Predicting protein condensate formation using machine learning

Guido van Mierlo, Jurriaan Jansen, Simon van Heeringen and Michiel Vermeulen and colleagues recently published in Cell Reports that predicting protein condensate formation can be done using machine learning.

RIMLS online award ceremony proudly presenting the winners

In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony. 

NWO ENW KLEIN grant awarded to Koen van den Dries and Michiel Vermeulen

Koen van den Dries will investigate the molecular mechanisms of actin isoform usage in cancer cell migrations. Michiel Vermeulen will search for proteins that interact with adenosine diphosphate ribose chains and play a role in the cellular response to damage to DNA.

Radboudumc signs collaboration agreement to develop personalized diagnostics

Radboudumc together with scientists from Erasmus MC has signed a license agreement with Sebia, world leader in multiple myeloma diagnostics.

Granted research projects 2020 by Hanarth Fonds

The Hanarth Fonds finances research projects of Iris Nagtegaal and Johannes Textor that use artificial intelligence or machine learning to improve the diagnosis, treatment and outcome of patients with cancer.

Dynamic plasma membrane organization a complex symphony

Sjoerd van Deventer, Abbey Arp and Annemiek van Spriel, published in Trends in cell biology that a dynamic plasma membrane organization is a complex symphony.

Controlled human malaria infection induces long-term functional changes in monocytes

Robert Sauerwein and Henk Stunnenberg together with Mihai Netea and other colleagues now show for the first time that even a parasitic infection can train the immune system. The article is published in Frontiers in Molecular Biosciences.

NWO XS awarded to identify X inactivation proteins

NWO XS awarded to the lab of Hendrik Marks for identification of proteins that inactivate the female X chromosome.

Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation

A multidisciplinary team of RIMLS and Radboud University researchers published in Advanced Science that Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation.

The Metastatic Microbiome rewarded with a Dutch Cancer Society Grant

Annemarie Boleij, Iris Nagtegaal & Daniele Tauriello received the Dutch Cancer Society (KWF) Grant to explore the role of bacteria on colorectal cancer metastasis.

Dutch Cancer Society Grant received by Annemiek van Spriel and Laia Querol-Cano

Annemiek van Spriel and Laia Querol-Cano received a Dutch Cancer Society Grant of 700K euros to study the cancer cell surface in immunotherapy.

Tumor cells stimulate lipid biosynthesis in macrophages

RIMLS researchers wrote in the Journal for ImmunoTherapy of Cancer that improved lipid biosynthesis in human tumor-induced macrophages contributes to their protumoral characteristics.

Research into systemic anti-psoriasis therapies in patients aged 65+ Age alone should not be a limiting factor in treatment

Much research has been done on the effectiveness and safety of systemic antipsoriasis therapies in general, but the effectiveness in specifically older adults psoriasis patients has never been systematically assessed.

Tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

Carl Figdor and colleagues showed in Nature Communications that the tumour microenvironment (TME) forms a major obstacle in effective cancer treatment and for clinical success of immunotherapy.

Interference transitions in case of invasion of breast cancer determined by cell-cell adhesion and 3D matrix confinement

Peter Friedl and colleagues, theme Cancer development and immune defence, published in Nature Cell Biology (NCB) the mechanisms of jamming and unjamming transitions of mammary carcinoma invasion along tossue microtracks.

Collective invasion induced by autocrine purinergic loop through connexin-43 hemichannels

Peter Friedl, Paul Span and Antoine Khalil show in Journal of Cell Biology that breastcancer cells release purines into the extracellular space via connexin-43 hemichannels to control collective invasion.

TP53 allelic state is critical for diagnostic and prognostic precision in blood cancer

An international study, in which Joop Jansen participated, shows that a double mutaton in TP53 gene deteriotes the prognosis of a rare form of blood cancer. If there is only one mutation or no mutation, then the prognosis is better.

Software for ranking protein-protein interfaces Released by eScience Center

Li Xue of the CMBI contributed to the development of a software package that ranks and scores protein-protein interfaces (PPIs). This article was published in Software X.

New pluripotent state discovered during mouse embryonic development

In a joined effort with ErasmusMC, the team of Hendrik Marks identified an exciting new "rosette" state of pluripotency dependent of WNT and MEK signaling as reported in Nature Cell Biology.

HFSP Grant for Johannes Textor

Johannes Textor, theme Cancer development and immune defense, has been awarded a program grant of 1 million US dollars by The Human Frontier Science Program (HFSP) to investigate how T cells navigate extremely dense environments using experiments, modeling and methods from pedestrian dynamics.

Guiding the surgeon real-time tumor visualization during surgery

Incomplete excision of tumor tissue negatively affects the prognosis of the patient. RIHS researcher Mark Rijpkema and colleagues are working on the development of new dual-labeled tracers and currently are implementing this into the clinic.

NWO open call GROOT grant for Michiel Vermeulen

Michiel Vermeulen, theme Cancer development and immune defense, received a 300,000 EUR grant within the NWO-GROOT consortium. He will use mass spectrometry-based proteomics and interaction proteomics applications to study proteome and gene expression dynamics during early C. Elegans development.

NWO open call GROOT grant for Peter Friedl

Peter Friedl, theme Cancer development and immune defense, received a 300,000 EUR grant within the NWO-GROOT consortium "Active matter of cancer metastasis" to identify the mechanisms of collective metastasis in breast cancer.

Human pDCs attract cytolytic lymphocytes in anti-cancer vaccination

RIMLS researchers Jasper van Beek and Jolanda de Vries, theme Cancer development and immune defense, discovered that pDCs can efficiently recruit cytolytic immune effector cells, a property that could be exploited in anti-cancer vaccines. They have published these findings in Cell Reports.

ZonMw funding for teams of Michiel Vermeulen and Jolanda de Vries

The awarded research projects of RIMLS researchers Michiel Vermeulen, Jolanda de Vries, Gerty Schreibelt and Martijn Verdoes and colleagues will initiate new research lines and collaborations between various research groups.

RIMLS PhD retreat registration is open

Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.

p120-catenin-dependent collective brain infiltration by glioma cell networks

Pavlo Gritsenko and Peter Friedl, theme Cancer development and immune defense, report in Nature Cell Biology, that glioma cells infiltrate the brain by a collective network mechanism, which critically depends on p120 catenin. p120 thus represents a potential target to combat glioma.

Niels Stensen Fellowship for Jorieke Weiden

Jorieke Weiden was recently awarded a grant from the Niels Stensen Fellowship. Since the 1960s, the Niels Stensen Fellowship has been awarded annually to outstanding researchers who recently received their PhD to enable them to gain research experience at a top university or institute abroad.