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Controlled Human Malaria Infection Induces Long-Term Functional Changes in Monocytes
3 December 2020Robert Sauerwein and Henk Stunnenberg together with Mihai Netea and other colleagues now show for the first time that even a parasitic infection can train the immune system. The article is published in Frontiers in Molecular Biosciences.
Research into systemic anti-psoriasis therapies in patients aged 65+ Age alone should not be a limiting factor in treatment
27 August 2020Much research has been done on the effectiveness and safety of systemic antipsoriasis therapies in general, but the effectiveness in specifically older adults psoriasis patients has never been systematically assessed.
Tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture
26 August 2020Carl Figdor and colleagues showed in Nature Communications that the tumour microenvironment (TME) forms a major obstacle in effective cancer treatment and for clinical success of immunotherapy.
Interference transitions in case of invasion of breast cancer determined by cell-cell adhesion and 3D matrix confinement
25 August 2020Peter Friedl and colleagues, theme Cancer development and immune defence, published in Nature Cell Biology (NCB) the mechanisms of jamming and unjamming transitions of mammary carcinoma invasion along tossue microtracks.
Collective invasion induced by autocrine purinergic loop through connexin-43 hemichannels
13 August 2020Peter Friedl, Paul Span and Antoine Khalil show in Journal of Cell Biology that breastcancer cells release purines into the extracellular space via connexin-43 hemichannels to control collective invasion.
TP53 allelic state is critical for diagnostic and prognostic precision in blood cancer
12 August 2020An international study, in which Joop Jansen participated, shows that a double mutaton in TP53 gene deteriotes the prognosis of a rare form of blood cancer. If there is only one mutation or no mutation, then the prognosis is better.
HFSP Grant for Johannes Textor
30 March 2020Johannes Textor, theme Cancer development and immune defense, has been awarded a program grant of 1 million US dollars by The Human Frontier Science Program (HFSP) to investigate how T cells navigate extremely dense environments using experiments, modeling and methods from pedestrian dynamics.
Guiding the surgeon real-time tumor visualization during surgery
26 February 2020Incomplete excision of tumor tissue negatively affects the prognosis of the patient. RIHS researcher Mark Rijpkema and colleagues are working on the development of new dual-labeled tracers and currently are implementing this into the clinic.
NWO open call GROOT grant for Michiel Vermeulen
24 February 2020Michiel Vermeulen, theme Cancer development and immune defense, received a 300,000 EUR grant within the NWO-GROOT consortium. He will use mass spectrometry-based proteomics and interaction proteomics applications to study proteome and gene expression dynamics during early C. Elegans development.
Human pDCs attract cytolytic lymphocytes in anti-cancer vaccination
6 February 2020RIMLS researchers Jasper van Beek and Jolanda de Vries, theme Cancer development and immune defense, discovered that pDCs can efficiently recruit cytolytic immune effector cells, a property that could be exploited in anti-cancer vaccines. They have published these findings in Cell Reports.
ZonMw funding for teams of Michiel Vermeulen and Jolanda de Vries
4 February 2020The awarded research projects of RIMLS researchers Michiel Vermeulen, Jolanda de Vries, Gerty Schreibelt and Martijn Verdoes and colleagues will initiate new research lines and collaborations between various research groups.
RIMLS PhD retreat registration is open
23 January 2020Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.
p120-catenin-dependent collective brain infiltration by glioma cell networks
7 January 2020Pavlo Gritsenko and Peter Friedl, theme Cancer development and immune defense, report in Nature Cell Biology, that glioma cells infiltrate the brain by a collective network mechanism, which critically depends on p120 catenin. p120 thus represents a potential target to combat glioma.
Niels Stensen Fellowship for Jorieke Weiden
6 January 2020Jorieke Weiden was recently awarded a grant from the Niels Stensen Fellowship. Since the 1960s, the Niels Stensen Fellowship has been awarded annually to outstanding researchers who recently received their PhD to enable them to gain research experience at a top university or institute abroad.
Galectin-9 controls plasma membrane integrity of dendritic cells
16 December 2019Laia Querol Cano, theme Cancer development and immune defense, has discovered how galectin-9, a sugar-binding membrane organiser, governs dendritic cell function by intracellularly modulating actin cytoskeleton. These findings are published in the latest issue of iScience.
New insights into the initiation of T cell responses in the spleen
11 December 2019Carl Figdor and colleagues, theme Cancer development and immune defense, provide insights into the initiation of T cell responses in the spleen and their consequences for T cell differentiation. They have published their results in Proceedings of the National Academy of Sciences USA.
Exploration meeting Academic Alliance on Oncology
2 December 2019Within the Academic Alliance, the Maastricht UMC+ and Radboudumc are already working together in several areas. And this is happening in more and more fields. On 27 November researchers from both umc's met during the fourth Exploration meeting, this time with the theme: Oncology.
Five RIMLS researchers in top 1 percent by citations
26 November 2019Leo Joosten, Jos van der Meer, Mihai Netea, Henk Stunnenberg and Frank van de Veerdonk, made it to this year’s list of highly cited researchers. Researchers in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.
Collective cancer invasion forms an integrin-dependent radioresistant niche
29 October 2019Anna Häger and Peter Friedl, theme Cancer development and immune defense, identified a new niche of cancer cell survival and developed an integrin inhibition therapy to overcome resistance. They have published their results in JEM.
Algorithm to predict which cancer patients benefit from immunotherapy
29 October 2019Rik Lindeboom and Michiel Vermeulen, theme Cancer development and immune defense, have developed an algorithm that can predict which cancer patients are more likely to benefit from immunotherapy. This new technology’s potential is described in Nature Genetics.
KWF Roadshow 11 November 2019
10 October 2019In which way(s) can KWF provide optimal support to oncological research and care? How can we maximize impact on our investments? These questions are pivotal in Ambition 2030: the vision that KWF developed in close cooperation with stakeholders in the oncological field.
RIMLS 25 years jubilee festival The Future is Yesterday
3 October 2019Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...
A personal touch of Lenneke Cornelissen
5 September 2019In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Lenneke Cornelissen.
New technique boosts preclinical antibody research
30 August 2019Martijn Verdoes, theme Nanomedicine, and Bas van der Schoot, theme Cancer development and immune defense, developed a technique to engineer and produce antibodies quickly, easily and cheaply. The researchers published their results in the open access journal Science Advances.
Publication in Blood on CD37 mutations in lymphoma
26 August 2019Suraya Elfrink, in Annemiek van Spriel's research group Immune cell signaling, theme Cancer development and immune defense, published a manuscript in Blood reporting that tetraspanin CD37 is frequently mutated in patients with diffuse large B cell lymphoma occurring at immune-privileged sites.
Front cover Human Mutation
21 August 2019The MetaDome web server build to interpret genetic variants based on genetic tolerance and homologous protein domains is featured on the Cover of Human Mutation. MetaDome was developed by Laurens van de Wiel, Coos Baakman, Daan Gilissen, Joris Veltman, Gert Vriend and Christian Gilissen,
Awarded KWF grants for Radboudumc researchers
2 July 2019The Dutch Cancer Society (KWF) has awarded 25.5 million euros to 50 new research projects in 16 different institutes. 8 grants are awarded to Radboudumc researchers. We congratulate our researchers with this funding and wish them success with their great work.
New opportunity for Henk Stunnenberg
24 June 2019After more than 22 years, Henk Stunnenberg, theme Cancer development and immune defense, has left the Radboud University, Dept. of Molecular Biology, to take up a position at the Prinses Maxima Centre for pediatric oncology in Utrecht. On Friday 5 July a farewell drink is being organized.
Studying the function of liver cancer genes in mini-organs
24 May 2019Michiel Vermeulen, theme Cancer development and immune defense, and colleagues, have developed a human model in which they use organoids, or mini organs, to study the function of specific genes that are mutated in liver cancer. Their results were published in the scientific journal Cell Stem Cell.
Three VIDI grants for RIMLS researchers
24 May 2019Matthijs Jore, Daniele Tauriello and Johannes Textor are each to receive up to 800,000 euros to develop an innovative research theme and to build up their own research group. NWO is awarding the Vidi grant as part of the Innovational Research Incentives Scheme.
A cozy relationship; the enhancer landscape of embryonic stem cells
13 May 2019In Nature Cell Biology, Yaser Atlasi, Wout Megchelenbrink and colleagues from the group of Henk Stunnenberg, theme Cancer development and immune defense, published a combination of experimental and bioinformatic approaches to study enhancer regulation in different states of embryonic stem cells.
