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Research Themes Disorders of movement News
The following news items are related to the research theme Disorders of movement.
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Five million euro’s for joint research on rare movement disorders

29 March 2022

A Dutch consortium will receive almost 5 million euro’s from NWO to jointly start an ambitious project, called CureQ, on various rare and genetic brain disorders that lead to abnormal movements. Bart van de Warrenburg was one of the main applicants of this ‘Nationale Wetenschaps Agenda (NWA)’ grant.

Brain connectivity as biomarker for Parkinson's disease

24 February 2022

Changes in the dopaminergic system have been implicated in various neurological and psychiatric conditions including Parkinson’s disease. The current study is the first to enable the fMRI-based study of dopamine-specific projections in the human brain, thereby providing improved diagnostics.

Development of RNA therapy for rare movement disorder SCA7 Brain Foundation grant for Radboudumc and LUMC

3 February 2022

Neurologist Bart van de Warrenburg, together with Willeke van Roon-Mom and Annemieke Aartsma-Rus (both LUMC/Dutch Center for RNA Therapeutics), has been awarded 400,000 euros by the Dutch Brain Foundation to develop a genetic therapy for the rare hereditary movement disorder SCA7.

Aerobe exercise has a positive effect on brain function in Parkinson's disease patients

18 January 2022

Radboudumc researchers have shown that the brain function of patients with Parkinson's disease improved with regular exercise, which seems to strengthen the connections between different brain areas, while inhibiting brain shrinkage.

New genetic defect links cell biology and protein glycosylation

10 November 2021

Peter Linders, Dirk Lefeber and Geert van den Bogaart together with international colleagues have recently reported on novel cell biological insights, by identifying a genetic disorder in syntaxin-5 which allowed to unravel a new mechanism regulating intracellular transportation.

Impact of COVID-19 pandemic on mental health of Parkinson's patients

10 November 2021

The COVID-19 pandemic has introduced challenges to the social life and care of people with Parkinson’s disease (PD), which could potentially worsen mental health problems. A new study investigated this associaten and explored whether mental health and quality of life can be improved.

Tiny blood vessels, big problems Radboudumc receives grant for international collaboration

3 November 2021

The Radboudumc, together with the University of Cambridge, receives a grant of €1.8M from three collaborating cardiac foundations for international research into the small blood vessels in the brain. This study will be led by Neurologist Frank-Erik de Leeuw and internist Niels Riksen.

1.5 million euro grant for research into earlier recognition of Parkinson's disease

27 October 2021

Researchers aim to improve identification of early symptoms and subtypes of Parkinson's disease with large international study

Surprisingly dominant cause underlying type I congenital defect of glycosylation

21 October 2021

Alex Garanto, Melissa Bärenfänger, Mirian Janssen, and Dirk Lefeber published a new study, identifying a surprisingly dominant genetic cause underlying type I congenital defect of glycosylation with neuromusculoskeletal phenotypes.

Palliative care for people with Parkinson’s Disease and their family Caregivers Current state of affairs

7 October 2021

Advanced stage Parkinson’s disease can cause a variety of symptoms, for which palliative care can be beneficial, though research from the point of view of patients in later stages is still rare. Radboudumc researchers therefore placed their patients perspectives at the center of their recent study.

Infections increase risk to develop dementia

16 September 2021

In a recently published study, Radboudumc researchers investigated the effects of infectious events on cognitive decline and the development of dementia and its possible structural underpinning using pre- and post-infection MRI of the brain.

Treatment of brain diseases at risk if neuroscientists can no longer conduct their research

5 August 2021

In order to treat brain diseases such as depression, Alzheimer's or ADHD, more research into the brain is needed.

The crucial role of brain network efficiency in gait in patients with small vessel disease

20 May 2021

In the recently published work in NeuroImage: Clinical, from the Department of Neurology, Radboudumc researcher Mengfei Cai and his colleagues investigated the potential mechanisms of gait decline.

Detecting impaired respiratory muscle structure and function using ultrasound and magnetic resonance

17 May 2021

Jeroen van Doorn and colleagues published a comprehensive review on imaging of the respiratory muscles in neuromuscular disorders in the European Respiratory Journal

Grants for science communication at Radboudumc

22 April 2021

Scientists at the Radboudumc have received two KNAW grants, each worth 10,000 euros, for science communication. With the new fund, KNAW underlines importance of making science accessible.

High blood pressure variability a potential target for prevention of post-stroke dementia?

24 March 2021

Radboudumc researchers investigated whether blood pressure levels and blood pressure variability influence the risk of post-stroke dementia, in an attempt to find a potential target for prevention of post-stroke dementia. Findings are published in Journal of Hypertension.

‘Mind the gap‘ between clinician-based and patient-relevant outcome measures.

24 March 2021

Radboudumc researchers evaluated health-related quality of life, depressive symptoms, fatigue, and physical activity in patients with spinocerebellar ataxia. The results of this study, conducted at the Radboudumc Expert Center for Rare and Genetic Movement Disorders, is published in The Cerebellum.

Dirk Lefeber receives Vici grant

4 March 2021

Dirk Lefeber, Professor, theme Disorders of movement, receives a Vici grant worth 1.5 million euros. He will use this grant to investigate why sugar metabolism differs between organs by use of stem cell models of muscle and brain.

Apathy is an early predictor of dementia

16 December 2020

Apathy predicts some forms of dementia years before the first symptoms appear. This is the main finding of Rogier Kievit of the Radboudumc and colleagues from the University of Cambridge in their publication today in Alzheimer's & Dementia.

Exoskeleton home and community use in people with complete spinal cord injury

15 October 2020

Radboudumc researchers are first to study actual exoskeleton use in the home and community environment in people with motor complete spinal cord injury.

UMD Catalist grant for Mohammad Alsady and Federica Conte

24 June 2020

They received this award to explore the potential of hiPS-derived skeletal muscle cells as model to investigate muscular pathophysiologic mechanisms in phosphoglucomutase I deficiency.

Bas Bloem elected as new member of the KNAW

30 April 2020

Bas Bloem is an expert in Parkinson's disease. He is also a healthcare innovator, focused on the integration of scientific research and its clinical applications. We congratulate Bas with this election.

Vision Problems May Be Common in People with Parkinson’s Disease

17 March 2020

Vision and eye problems are much more common in people with Parkinson’s disease than in people without the disorder.

Preserved specific force in facioscapulohumeral muscular dystrophy

19 February 2020

DCMN researcher Saskia Lassche et al., theme Disorders of Movement, recently showed in Neurology that remaining muscle fibers in Facioscapulohumeral muscular dystrophy (FSHD) patients  have normal muscle strength, even in severely affected muscles.

DCMN big data mini-symposium held on 31 January

5 February 2020

On 31 January, DCMN researchers and collaborators gathered to talk about big data, as a means to work towards Open Science.

European grant for rare neurological disease

9 January 2020

Together with a consortium of European researchers, neurologist and Donders PI Bart van de Warrenburg and RIHS researcher Marjan Meinders have received a 2 million euro grant for research into rare neurological movement disorders: spastic ataxia.

'Stofwisselkracht' grant for Paola de Haas and Alessandra Cambi

5 December 2019

Paola de Haas and Alessandra Cambi, theme Nanomedicine, have recently been awarded a grant from ‘Stichting Stofwisselkracht’ for their project entitled “Identification of immune-related symptoms in Congenital Disorders of Glycosylation”.

Newly appointed Principal Clinicians RIHS 2020 - 2022

5 December 2019

These caregivers are at the forefront of renewing patient care and take the lead in the development and realization of the Radboud vision.

Bart van de Warrenburg appointed visiting professor at the UKM Medical Centre in Kuala Lumpur

11 November 2019

Neurologist and Principal Investigator at the Donders Institute Bart van de Warrenburg has been appointed visiting professor at the UKM Medical Centre in Kuala Lumpur.

KNAW Van Leersum beurs for Mohammad Alsady

7 November 2019

Mohammad Alsady, theme Disorders of movement, received the “KNAW Van Leersum beurs”.

Self-management rehabilitation program improves participation in patients with neuromuscular disease

4 November 2019

Yvonne Veenhuizen, Alexander Geurts theme Neurorehabilitation, Baziel van Engelen, theme Disorders of movement, and colleagues, showed that Energetic improves participation in patients with neuromuscular disease. They have published their results in Neurology.

Towards molecular therapies for Myotonic Dystrophy

1 October 2019

ReCognitION, a new 1.3 M€ European project under the leadership of Peter-Bram ‘t Hoen, Baziel van Engelen and Jeffrey Glennon, was kicked-off in Gent.

Exercising at home has a positive effect on Parkinson's patients

19 September 2019

In a large double-blind study, Radboudumc researchers show that patients in the early stages of Parkinson's disease can exercise regularly at home for 6 months.

Useful new test for Parkinson's disease

28 March 2019

Diagnosing Parkinson's is not easy. In particular in the early stages, it can be difficult to distinguish Parkinson's from a group of other disorders that at first sight look identical.

Walking ability in Parkinson patients improves with the clever use of self-discovered compensation strategies

26 March 2019

Losing the ability to walk normally is a widespread problem for people with Parkinson's disease. However, patients themselves frequently discover innovative compensation strategies to circumvent their walking problems.

Standing balance capacity is easily overestimated in well-recovered stroke survivors

20 February 2019

In Neurorehabilitation and Neural Repair Jolanda Roelofs and Sander Geurts showed that well-recovered persons in the chronic phase after stroke with clinically no (or only very limited) motor impairment of the affected leg may still show substantial problems with standing balance control.

Specific sugar is important for muscle function Treat a genetic condition with a pinch of sugar?

2 January 2019

Dirk Lefeber and colleagues have discovered that the sugar sialic acid is important for good muscle and heart function. In a family with muscle problems, they discovered a mistake in a gene that prevents the breakdown of sialic acid.

Christine Mohrmann stipendium for Karlien Mul

14 December 2018

The goal of the stipendium is to enable junior female scientists to perform research abroad and to encourage them to pursue a scientific career in academia.

Identification of clinically recognizable subtypes of ataxia telangiectasia

12 December 2018

In their latest publication in Neurology, Bart van de Warrenburg and Nienke van Os have identified clinically recognizable subtypes within milder forms of ataxia telangiectasia.

Two Stofwisselkracht Foundation grants for research into glycosylation related neuromuscular diseases

12 November 2018

The Stofwisselkracht Foundation raises funds for research into metabolic diseases in a sporting and original way.

European Stroke Action Plan

1 November 2018

On 29 October it was World Stroke Day. On this day European researchers presented an action plan to improve stroke care in Europe. Edo Richard, Karin Klijn and Frank-Erik de Leeuw from Radboudumc contributed to this action plan.

New neural pathway in the brain discovered by Radboudumc researchers

25 October 2018

Researchers at Radboudumc have discovered a new neural pathway in the human brain by using various imaging techniques. This discovery may have an impact on the treatment of facial pain and other issues.

Bas Bloem newly elected in Academia Europaea

25 October 2018

Academia Europaea boasts European scientists from across the entire range of sciences. Each year, the most engaging international candidates are selected.

Awardees DCMN Junior Researcher round 2019

4 October 2018

DCMN launched a call call for Radboudumc junior researcher (PhD) positions. This year 6 positions have awarded.

Dirk Lefeber appointed as Professor of Glycosylation Disorders

3 October 2018

Dirk Lefeber has been appointed professor of Glycosylation Disorders. Lefeber leads the research group Glycosylation Disorders in Neurology.

Bas Bloem receives Tom Isaacs Award for effort to improve the lives of people with Parkinson’s

2 October 2018

Bas Bloem receives the Tom Isaacs award 2018. Andel Research Institute and The Cure Parkinson’s Trust awarded Bloem, together with Simon Stott, as scientists who strive to improve the lives of people with Parkinson's.

Cognitive behavioral therapy effective in MD1 New treatment option for complex disease

21 September 2018

Treatment with cognitive behavioral therapy helps patients with myotonic dystrophy type 1 in improving their physical abilities and social participation. This is the result of a survey of more than 250 patients in four European countries.

Last chance to register for ENABLE 2018

20 September 2018

The 2nd ENABLE symposium entitled “The promise of future medicine: from research to therapy” will be hosted in Copenhagen, from 7 - 9 November. Don’t miss out, registration closes 30 September.

Successful teamwork between Neurology and Human Genetics leads to identification of two new ataxia genes

19 September 2018

Thanks to close cooperation between Bart van de Warrenburg (Neurology) and Erik-Jan Kamsteeg (Humans Genetics) two new genes involved in movement disorders were identified. The genes are relevant for autosomal recessive cerebellar ataxia.

Gatsby Foundation donates 10 million to improve Parkinson's care UK foundation supports rigorous healthcare innovation in the Netherlands

15 August 2018

The Parkinson center for expertise receives 10 million euros from the Gatsby Foundation. Thanks to this private donation they can implement a new healthcare model that focuses on the desires and needs of people with Parkinson's disease.