Five million euro’s for joint research on rare movement disorders29 March 2022
A Dutch consortium will receive almost 5 million euro’s from NWO to jointly start an ambitious project, called CureQ, on various rare and genetic brain disorders that lead to abnormal movements. Bart van de Warrenburg was one of the main applicants of this ‘Nationale Wetenschaps Agenda (NWA)’ grant.
Brain connectivity as biomarker for Parkinson's disease24 February 2022
Changes in the dopaminergic system have been implicated in various neurological and psychiatric conditions including Parkinson’s disease. The current study is the first to enable the fMRI-based study of dopamine-specific projections in the human brain, thereby providing improved diagnostics.
Development of RNA therapy for rare movement disorder SCA7 Brain Foundation grant for Radboudumc and LUMC3 February 2022
Neurologist Bart van de Warrenburg, together with Willeke van Roon-Mom and Annemieke Aartsma-Rus (both LUMC/Dutch Center for RNA Therapeutics), has been awarded 400,000 euros by the Dutch Brain Foundation to develop a genetic therapy for the rare hereditary movement disorder SCA7.
Aerobe exercise has a positive effect on brain function in Parkinson's disease patients18 January 2022
Radboudumc researchers have shown that the brain function of patients with Parkinson's disease improved with regular exercise, which seems to strengthen the connections between different brain areas, while inhibiting brain shrinkage.
New genetic defect links cell biology and protein glycosylation10 November 2021
Peter Linders, Dirk Lefeber and Geert van den Bogaart together with international colleagues have recently reported on novel cell biological insights, by identifying a genetic disorder in syntaxin-5 which allowed to unravel a new mechanism regulating intracellular transportation.
Impact of COVID-19 pandemic on mental health of Parkinson's patients10 November 2021
The COVID-19 pandemic has introduced challenges to the social life and care of people with Parkinson’s disease (PD), which could potentially worsen mental health problems. A new study investigated this associaten and explored whether mental health and quality of life can be improved.
Tiny blood vessels, big problems Radboudumc receives grant for international collaboration3 November 2021
The Radboudumc, together with the University of Cambridge, receives a grant of €1.8M from three collaborating cardiac foundations for international research into the small blood vessels in the brain. This study will be led by Neurologist Frank-Erik de Leeuw and internist Niels Riksen.
Surprisingly dominant cause underlying type I congenital defect of glycosylation21 October 2021
Alex Garanto, Melissa Bärenfänger, Mirian Janssen, and Dirk Lefeber published a new study, identifying a surprisingly dominant genetic cause underlying type I congenital defect of glycosylation with neuromusculoskeletal phenotypes.
Palliative care for people with Parkinson’s Disease and their family Caregivers Current state of affairs7 October 2021
Advanced stage Parkinson’s disease can cause a variety of symptoms, for which palliative care can be beneficial, though research from the point of view of patients in later stages is still rare. Radboudumc researchers therefore placed their patients perspectives at the center of their recent study.
Infections increase risk to develop dementia16 September 2021
In a recently published study, Radboudumc researchers investigated the effects of infectious events on cognitive decline and the development of dementia and its possible structural underpinning using pre- and post-infection MRI of the brain.
The crucial role of brain network efficiency in gait in patients with small vessel disease20 May 2021
In the recently published work in NeuroImage: Clinical, from the Department of Neurology, Radboudumc researcher Mengfei Cai and his colleagues investigated the potential mechanisms of gait decline.
High blood pressure variability a potential target for prevention of post-stroke dementia?24 March 2021
Radboudumc researchers investigated whether blood pressure levels and blood pressure variability influence the risk of post-stroke dementia, in an attempt to find a potential target for prevention of post-stroke dementia. Findings are published in Journal of Hypertension.
‘Mind the gap‘ between clinician-based and patient-relevant outcome measures.24 March 2021
Radboudumc researchers evaluated health-related quality of life, depressive symptoms, fatigue, and physical activity in patients with spinocerebellar ataxia. The results of this study, conducted at the Radboudumc Expert Center for Rare and Genetic Movement Disorders, is published in The Cerebellum.
Preserved specific force in facioscapulohumeral muscular dystrophy19 February 2020
DCMN researcher Saskia Lassche et al., theme Disorders of Movement, recently showed in Neurology that remaining muscle fibers in Facioscapulohumeral muscular dystrophy (FSHD) patients have normal muscle strength, even in severely affected muscles.
European grant for rare neurological disease9 January 2020
Together with a consortium of European researchers, neurologist and Donders PI Bart van de Warrenburg and RIHS researcher Marjan Meinders have received a 2 million euro grant for research into rare neurological movement disorders: spastic ataxia.
'Stofwisselkracht' grant for Paola de Haas and Alessandra Cambi5 December 2019
Paola de Haas and Alessandra Cambi, theme Nanomedicine, have recently been awarded a grant from ‘Stichting Stofwisselkracht’ for their project entitled “Identification of immune-related symptoms in Congenital Disorders of Glycosylation”.
Self-management rehabilitation program improves participation in patients with neuromuscular disease4 November 2019
Yvonne Veenhuizen, Alexander Geurts theme Neurorehabilitation, Baziel van Engelen, theme Disorders of movement, and colleagues, showed that Energetic improves participation in patients with neuromuscular disease. They have published their results in Neurology.
Walking ability in Parkinson patients improves with the clever use of self-discovered compensation strategies26 March 2019
Losing the ability to walk normally is a widespread problem for people with Parkinson's disease. However, patients themselves frequently discover innovative compensation strategies to circumvent their walking problems.
Standing balance capacity is easily overestimated in well-recovered stroke survivors20 February 2019
In Neurorehabilitation and Neural Repair Jolanda Roelofs and Sander Geurts showed that well-recovered persons in the chronic phase after stroke with clinically no (or only very limited) motor impairment of the affected leg may still show substantial problems with standing balance control.
Specific sugar is important for muscle function Treat a genetic condition with a pinch of sugar?2 January 2019
Dirk Lefeber and colleagues have discovered that the sugar sialic acid is important for good muscle and heart function. In a family with muscle problems, they discovered a mistake in a gene that prevents the breakdown of sialic acid.
Bas Bloem receives Tom Isaacs Award for effort to improve the lives of people with Parkinson’s2 October 2018
Bas Bloem receives the Tom Isaacs award 2018. Andel Research Institute and The Cure Parkinson’s Trust awarded Bloem, together with Simon Stott, as scientists who strive to improve the lives of people with Parkinson's.
Cognitive behavioral therapy effective in MD1 New treatment option for complex disease21 September 2018
Treatment with cognitive behavioral therapy helps patients with myotonic dystrophy type 1 in improving their physical abilities and social participation. This is the result of a survey of more than 250 patients in four European countries.
Successful teamwork between Neurology and Human Genetics leads to identification of two new ataxia genes19 September 2018
Thanks to close cooperation between Bart van de Warrenburg (Neurology) and Erik-Jan Kamsteeg (Humans Genetics) two new genes involved in movement disorders were identified. The genes are relevant for autosomal recessive cerebellar ataxia.
Gatsby Foundation donates 10 million to improve Parkinson's care UK foundation supports rigorous healthcare innovation in the Netherlands15 August 2018
The Parkinson center for expertise receives 10 million euros from the Gatsby Foundation. Thanks to this private donation they can implement a new healthcare model that focuses on the desires and needs of people with Parkinson's disease.