News

Autoantibody profiles in systemic sclerosis a comparison of diagnostic tests

The research of Ruben Smeets and colleagues in Autoimmunity showed high concordance of prevalent SSc-specific autoantibodies between different diagnostic assays. Further standardisation for low prevalent SSc-specific and SSc-associated autoantibodies is needed.

One drop of blood brings progression of multiple myeloma into better view

Sensitive test opens door to personalized therapy

Immunomodulatory aged neutrophils are augmented in blood and skin of psoriasis patients

A new study by Radboudumc researchers show that Psoriatic patients have a unique neutrophil profile in circulation, and two distinct neutrophils subsets are present in psoriatic skin. The results are published in the Journal of Allergy and Clinical Immunology on the 19th of March. 

ZonMw grants to study optimal use of COVID-19 vaccines in patients with impaired immune systems

How do people with reduced immunity, especially kidney patients, react to a COVID-19 vaccination? And how can patients with peripheral arterial disease be helped by DNA testing? Our researchers received grants from ZonMw to make these studies possible.

RIMLS online award ceremony proudly presenting the winners

In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony. 

Vote for the Supervisor of the year

Now you have the chance to vote for your preferred candidate. Have fun, and go for it, support and promote your ideal supervisor. Please submit your vote at the latest 4 January 2021.

967K Euro grant to develop organoids enabling new research methods for skin disorders

Ellen van den Bogaard will lead a consortium, financed by Health Holland, to establish a platform in which materials and technologies are developed to stimulate research with so-called skin organoids, small pieces of cultured skin.

Uterine B cells involved in healthy pregnancy more insight in the development of pregnancy complications

Immune cells in the uterine wall are important for a successful pregnancy. In a publication in Cell Reports, Marilen Benner and colleagues show that B-cells play an important role in this.

Best publication award of 2019 in dermatology awarded to Jos Smits and Tom Ederveen

The Dutch Society for Experimental Dermatology (NVED) awarded the publication in Journal of Investigative Dermatology of Jos Smits and Tom Ederveen.

Radboudumc does large-scale research on systemic sclerosis

In rare diseases, such as systemic sclerosis, it’s often difficult to conduct large-scale research. Rheumatologist Madelon Vonk has managed to follow enough patients with systemic sclerosis for years. The results of her research have been published in BMJ Annal of the Rheumatic Diseases.

New insight into the effect of hydroxychloroquine undermines its use in corona

Researchers at Radboud university medical center have discovered an as yet unknown effect of hydroxychloroquine. Raphael Duivenvoorden was interviewed in the program Op1 at NPO1 to elaborate on the findings. It seems unlikely that chloroquine has beneficial effect in corona infections.

OARSI Basic Science Award for Peter van der Kraan

Purpose of this Basic Science Award of the Osteoarthritis Research Society International (OARSI) is to stimulate fundamental research in the field of osteoarthritis. Congratulations Peter.

Tight controlled dose reduction of biologics in psoriasis patients

Published in JAMA Dermatology, RIHS researcher Selma Atalay and colleagues investigated in a randomized controlled trial a tight controlled dose reduction strategy of the biologics adalimumab, etanercept and ustekinumab in psoriasis patients.

New EU Research project ImmUniverse

In this project (31 mEURO), RIMLS and RIHS researchers collaborate with 25 European partners on dissecting common disease mechanisms of Ulcerative Colitis and Atopic Dermatitis.

Researchers investigate how stem cells affect the immune system

RIMLS researchers Irma Joosten and Renate van der Molen, participating in an European study into the treatment of brain damage in premature babies. Is it possible to limit or even partly repair the damage with stem cells? They focus primarily on the effect of those stem cells on the immune system.

RIMLS PhD retreat registration is open

Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.

First BeNeFit funding granted for psoriasis

RIHS researchers Elke de Jong and Juul van den Reek of Dermatology Radboudumc and Dermatology Ghent received a grant of 1.6 million euros for investigating dose reduction of the newest biologics for psoriasis.

PPP allowance by Health~Holland for Fons van de Loo

Fons van de Loo, theme Inflammatory diseases, has been granted a 3 year PPP Allowance made available by Health~Holland for the project ‘REFIT’. The goal of this project is to restore the barrier function, immunity and microbiome of the intestinal tract using extracellular vesicles from milk.

RIMLS awards call for nominations

RIMLS awards several prizes to stimulate and honor our (young) researchers. Please find here an overview of the upcoming awards. Deadline 12 December 2019.

Two projects granted for Experimental Rheumatology

Osteoarthritis is the most prevalent and debilitating joint disease worldwide but no cure has been developed yet. Recent findings show that low grade inflammation within the OA joint contributes to the pathophysiology and clinical symptoms. Both Peter van Lent and Fons van de Loo received a grant.

RIMLS 25 years jubilee festival The Future is Yesterday

Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...

Radboud-led collaboration generates innovative candidate drug against malaria

A molecule once designed to cure the skin disease psoriasis appears to be particularly effective against malaria. The antimalarial properties were revealed thanks to one researcher’s inspired hunch when the psoriasis drug discovery programme came to a dead end.

It is raining Horizon 2020 grants for RIMLS researchers

Horizon 2020 is the biggest EU Research and Innovation programme ever with nearly €80 billion of funding available and running from 2014 to 2020. This summer, no less than 8 proposals for the Radboudumc have been accepted, 4 of them even as a coordinator.

Floris Schreuder received Dekker grant

Floris Schreuder received one of the ten Dekker grants from the Dutch Heart Foundation (Hartstichting).

Four Veni grants for junior RIMLS researchers

Four junior researchers, affiliated to the RIMLS, have each received a Veni grant of 250,000 Euro from NWO. Our researchers received this prestigious grant for their remarkable and original talent and their ability to carry out innovative research.

Peter van der Kraan new theme leader Inflammatory diseases

It is our pleasure to introduce Peter van der Kraan from the Dept. of Rheumatology, as the new leader of our theme Inflammatory diseases. As such he will be the successor of Irma Joosten who has done an outstanding job in the last years as theme leader, for which we thank her wholeheartedly.

A personal touch of Hanna Niehues

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Hanna Niehues.

ReumaNederland grant for Peter van der Kraan

Peter van der Kraan, theme Inflammatory diseases received € 500,000 for research into the development of cartilage damage and pain in knee osteoarthritis.

EU funded project BIOMAP led by Ellen van den Bogaard

Ellen van den Bogaard, theme Inflammatory diseases, leads the research on the experimental validation and functional analysis of identified biomarkers by using advanced organotypic skin models and receives a grant of €258,000.

Call for RIMLS Junior Researcher 2020

In 2020 funding will be made available for 8 RIMLS Junior Researcher projects. The call for these PhD grants is now open.

Celebrations to mark the retirement of Joost Schalkwijk

With a mini symposium (‘Oppervlakkig en toch diepgaand’) and reception a passionate researcher of the RIMLS said farewell. After 36 working years Joost Schalkwijk, theme Inflammatory diseases, will enjoy his retirement.

Endometrial natural killer cells remember previous pregnancy

Dorien Feyaerts, theme Inflammatory diseases, showed that pregnancy induces a memory phenotype on endometrial natural killer cells. However, previous CMV infection is a prerequisite for this memory induction. They published their findings in Cellular and Molecular Immunology.

A personal touch of Irma Joosten

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Irma Joosten.

LEO Foundation grant for Ellen van den Bogaard and Patrick Zeeuwen

LEO Foundation ‘Open competition grants’ are given to support the best dermatology research projects worldwide that improve the understanding of the underlying medicinal, biological, chemical, or pharmacological mechanisms of dermatological diseases and their symptoms.

RIMLS awards festival Twelve winners

In 5 categories RIMLS young researchers received an award and bonus during the New Year's drinks. See all photo's.

Two grants for Rheumatology awarded by Dutch Arthritis Association

Two projects of Arjen Blom and Peter van Lent, theme Inflammatory diseases, were granted by the Dutch Arthritis Association (€ 160,000 per project).

Super surgeons together with the RoboSculpt

One of the first autonomous surgical robotics – the RoboSculpt – has been tested pre-clinically on cadavers last week for the first time in our Radboudumc in collaboration with Eindhoven Medical Robotics (EMR).

ZonMw Off-road subsidy for Ellen van den Bogaard

This year ZonMw granted Ellen van den Bogaard an Off Road subsidy for her project: 'Op de huid gezeten'.

A new autosomal-recessive hypotrichosis syndrome

Ellen van den Bogaard, theme Inflammatory diseases and Patrick Zeeuwen, theme Infectious diseases and global health, report the first family with cystatin M/E deficiency in Genetics in Medicine.

Validation of ACCESS: an automated tool to support self-management of COPD exacerbations

In the International Journal of Chronic Obstructive Pulmonary Disease Lonneke Boer and colleagues described the validity of an innovative software application that provides automated treatment advice to patients with COPD without the interference of a health care professional.

Report of the 12th New Frontiers symposium Big data, better healthcare? - 1 November 2018

Examples from the application of deep learning to image reading in pathology and radiology and the application of network medicine to monitor infectious disease outbreaks or collective mood states using twitter data showed the huge potential of big data approaches for building better healthcare.

Report of the 12th New Frontiers symposium Better care, network care? - 2 November 2018

No easy answers at this symposium last Friday, only challenges that can be overcome if we succeed in 5 things. First and most radically, put patients in the center of healthcare. Second, start with assessing what the local population needs and not what local professionals have to offer.

Public evening 'Dag Dokter'

Last chance to register for ENABLE 2018

The 2nd ENABLE symposium entitled “The promise of future medicine: from research to therapy” will be hosted in Copenhagen, from 7 - 9 November. Don’t miss out, registration closes 30 September.

Best PhD T@lk award for Daphne Dorst

During a special edition of the Radboud Research Round of the theme Inflammatory diseases, organized by and for PhD candidates, Daphne Dorst received the award for the best PhD t@lk.

ZonMw grant of 250k for Erik Bischoff

Erik Bischoff received a ZonMw grant of 250K for his project ‘A whole system multimorbidity approach to improve patient centred chronic disease management in primary care’.

Nielka van Erp and Roger Brüggemann appointed associate professor

It is our pleasure to announce that Nielka van Erp and Roger Brüggemann have been appointed as associated professor.

TNFAIP3/A20 protein: the gatekeeper in inflammation and autoimmunity

Paulo Urbano and Hans Koenen, theme Inflammatory diseases, recently published an article in the Journal of Allergy and Clinical Immunology (JACI).

NWO Partnership TTW-Nutricia in the EARLYFIT study

Collaboration between Wageningen University, LUMC and Radboudumc to investigate the role of infant formula with synbiotics on immune fitness in the EARLYFIT study.

Endometrial natural killer cells reveal a tissue-specific receptor repertoire

Cytotoxic natural killer cells are specialized in discriminating potentially dangerous cells and healthy “self” cells. In a report in Human Reproduction, Dorien Feyaerts and colleagues demonstrated that these cells have a unique tissue-specific signature in the pre-pregnancy endometrium.