Autoantibody profiles in systemic sclerosis a comparison of diagnostic tests8 April 2021
The research of Ruben Smeets and colleagues in Autoimmunity showed high concordance of prevalent SSc-specific autoantibodies between different diagnostic assays. Further standardisation for low prevalent SSc-specific and SSc-associated autoantibodies is needed.
Immunomodulatory aged neutrophils are augmented in blood and skin of psoriasis patients24 March 2021
A new study by Radboudumc researchers show that Psoriatic patients have a unique neutrophil profile in circulation, and two distinct neutrophils subsets are present in psoriatic skin. The results are published in the Journal of Allergy and Clinical Immunology on the 19th of March.
ZonMw grants to study optimal use of COVID-19 vaccines in patients with impaired immune systems3 February 2021
How do people with reduced immunity, especially kidney patients, react to a COVID-19 vaccination? And how can patients with peripheral arterial disease be helped by DNA testing? Our researchers received grants from ZonMw to make these studies possible.
RIMLS online award ceremony proudly presenting the winners13 January 2021
In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony.
967K Euro grant to develop organoids enabling new research methods for skin disorders11 November 2020
Ellen van den Bogaard will lead a consortium, financed by Health Holland, to establish a platform in which materials and technologies are developed to stimulate research with so-called skin organoids, small pieces of cultured skin.
Uterine B cells involved in healthy pregnancy more insight in the development of pregnancy complications30 September 2020
Immune cells in the uterine wall are important for a successful pregnancy. In a publication in Cell Reports, Marilen Benner and colleagues show that B-cells play an important role in this.
Radboudumc does large-scale research on systemic sclerosis10 September 2020
In rare diseases, such as systemic sclerosis, it’s often difficult to conduct large-scale research. Rheumatologist Madelon Vonk has managed to follow enough patients with systemic sclerosis for years. The results of her research have been published in BMJ Annal of the Rheumatic Diseases.
New insight into the effect of hydroxychloroquine undermines its use in corona11 June 2020
Researchers at Radboud university medical center have discovered an as yet unknown effect of hydroxychloroquine. Raphael Duivenvoorden was interviewed in the program Op1 at NPO1 to elaborate on the findings. It seems unlikely that chloroquine has beneficial effect in corona infections.
Tight controlled dose reduction of biologics in psoriasis patients7 May 2020
Published in JAMA Dermatology, RIHS researcher Selma Atalay and colleagues investigated in a randomized controlled trial a tight controlled dose reduction strategy of the biologics adalimumab, etanercept and ustekinumab in psoriasis patients.
Researchers investigate how stem cells affect the immune system18 February 2020
RIMLS researchers Irma Joosten and Renate van der Molen, participating in an European study into the treatment of brain damage in premature babies. Is it possible to limit or even partly repair the damage with stem cells? They focus primarily on the effect of those stem cells on the immune system.
RIMLS PhD retreat registration is open23 January 2020
Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.
PPP allowance by Health~Holland for Fons van de Loo16 December 2019
Fons van de Loo, theme Inflammatory diseases, has been granted a 3 year PPP Allowance made available by Health~Holland for the project ‘REFIT’. The goal of this project is to restore the barrier function, immunity and microbiome of the intestinal tract using extracellular vesicles from milk.
Two projects granted for Experimental Rheumatology22 October 2019
Osteoarthritis is the most prevalent and debilitating joint disease worldwide but no cure has been developed yet. Recent findings show that low grade inflammation within the OA joint contributes to the pathophysiology and clinical symptoms. Both Peter van Lent and Fons van de Loo received a grant.
RIMLS 25 years jubilee festival The Future is Yesterday3 October 2019
Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...
Radboud-led collaboration generates innovative candidate drug against malaria19 September 2019
A molecule once designed to cure the skin disease psoriasis appears to be particularly effective against malaria. The antimalarial properties were revealed thanks to one researcher’s inspired hunch when the psoriasis drug discovery programme came to a dead end.
It is raining Horizon 2020 grants for RIMLS researchers15 August 2019
Horizon 2020 is the biggest EU Research and Innovation programme ever with nearly €80 billion of funding available and running from 2014 to 2020. This summer, no less than 8 proposals for the Radboudumc have been accepted, 4 of them even as a coordinator.
Four Veni grants for junior RIMLS researchers22 July 2019
Four junior researchers, affiliated to the RIMLS, have each received a Veni grant of 250,000 Euro from NWO. Our researchers received this prestigious grant for their remarkable and original talent and their ability to carry out innovative research.
Peter van der Kraan new theme leader Inflammatory diseases13 June 2019
It is our pleasure to introduce Peter van der Kraan from the Dept. of Rheumatology, as the new leader of our theme Inflammatory diseases. As such he will be the successor of Irma Joosten who has done an outstanding job in the last years as theme leader, for which we thank her wholeheartedly.
Endometrial natural killer cells remember previous pregnancy11 February 2019
Dorien Feyaerts, theme Inflammatory diseases, showed that pregnancy induces a memory phenotype on endometrial natural killer cells. However, previous CMV infection is a prerequisite for this memory induction. They published their findings in Cellular and Molecular Immunology.
LEO Foundation grant for Ellen van den Bogaard and Patrick Zeeuwen17 January 2019
LEO Foundation ‘Open competition grants’ are given to support the best dermatology research projects worldwide that improve the understanding of the underlying medicinal, biological, chemical, or pharmacological mechanisms of dermatological diseases and their symptoms.
Validation of ACCESS: an automated tool to support self-management of COPD exacerbations13 November 2018
In the International Journal of Chronic Obstructive Pulmonary Disease Lonneke Boer and colleagues described the validity of an innovative software application that provides automated treatment advice to patients with COPD without the interference of a health care professional.
Report of the 12th New Frontiers symposium Big data, better healthcare? - 1 November 20187 November 2018
Examples from the application of deep learning to image reading in pathology and radiology and the application of network medicine to monitor infectious disease outbreaks or collective mood states using twitter data showed the huge potential of big data approaches for building better healthcare.
Report of the 12th New Frontiers symposium Better care, network care? - 2 November 20187 November 2018
No easy answers at this symposium last Friday, only challenges that can be overcome if we succeed in 5 things. First and most radically, put patients in the center of healthcare. Second, start with assessing what the local population needs and not what local professionals have to offer.
Endometrial natural killer cells reveal a tissue-specific receptor repertoire19 April 2018
Cytotoxic natural killer cells are specialized in discriminating potentially dangerous cells and healthy “self” cells. In a report in Human Reproduction, Dorien Feyaerts and colleagues demonstrated that these cells have a unique tissue-specific signature in the pre-pregnancy endometrium.