News

Camille Le Gall reports an efficient approach for delivery of poorly soluble tumor antigens to human cDC1s

Camille Le Gall published about an efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion in the Journal of Immunotherapy of Cancer.

Rubicon grants awarded to three RIMLS researchers

Three researchers have received Rubicon funding from NWO/ZonMw. This will enable Elke Muntjewerff, Laura de Vries and Laurens van de Wiel to do research at a foreign research institute for the next two years.

Large NWA ORC grant awarded for national skin research: Next Generation ImmunoDermatology

Research for better treatment methods for chronic skin diseases.

Scan avoids unnecessary surgery for thyroid nodules PET scan with radioactive sugar is effective, cost-saving and safe

ERC Proof of Concept Grant for Martijn Verdoes

Martijn Verdoes, group leader Chemical Immunology at the department of Tumor Immunology, has been awarded an ERC Proof of Concept (PoC) Grant. The ERC PoC Grants are designed to support ERC grantees with the commercial or societal application of the results of their funded research.

NWO OTP grant to investigate fibrotic diseases with organ-on-a-chip technology

Wouter Verdurmen & Peter van der Kraan have been awarded with a grant by the Netherlands Organisation for Scientific Research (NWO-OTP) to develop and employ innovative organ-on-a-chip models to investigate fibrotic diseases, with a particular focus on systemic sclerosis.

New genetic defect links cell biology and protein glycosylation

Peter Linders, Dirk Lefeber and Geert van den Bogaart together with international colleagues have recently reported on novel cell biological insights, by identifying a genetic disorder in syntaxin-5 which allowed to unravel a new mechanism regulating intracellular transportation.

RIMLS awards call for nominations

RIMLS awards several prizes to stimulate and honor our (young) researchers. Upcoming awards are Supervisor of the Year, Best Master Thesis, Best Publication, Best Image and more. Send your nominations now before 24 November 2021.

Turbo Grants for four medical-technical research projects

Four TURBO grants were recently awarded to new technical-medical research proposals. The grants are part of the TURBO program, a collaboration between the University of Twente (TechMed Centre) and the Radboudumc.

A hybrid in silico and tumor-on-a-chip approach to model targeted protein behavior in 3D microenvironments

Valentina Palacio-Castañeda published in Cancers about modeling the behavior of targeted proteins in 3D microenvironments by approaching a hybrid in silico and tumor-on-a-chip.

NWO-Groot grant awarded to Nico Sommerdijk for groundbreaking research with electron microscopy

NWO Large grant awarded to Nico Sommerdijk and colleagues

Miniaturized microfluidic platform for automated epigenetic profiling

Together with Fluidigm, a US-based company focusing on microfluidics, the team of Hendrik Marks publishes in Genome Research the development of a powerful plug and play ChIP-seq platform for minute amount of cells, such as embryonic specimens or small biopsies.

Nico Sommerdijk appointed professor of Bone Biochemistry

Marie Curie Fellowship for Elena Macías Sánchez

Elena Macías Sánchez has been awarded with a MSCA-IF to develop her project in the department of Biochemistry, RIMLS.

RIMLS online award ceremony proudly presenting the winners

In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony. 

Koen van den Dries received ENW-XS grant from the NWO

Koen van den Dries has received an ENW-XS grant from the NWO for his project titled: Small differences, large impact: how actin variants differentially control cancer cell migration.

NWO CHAINS 2020 poster prize winner: Judith Schaart

Judith Schaart wins the NWO CHAINS 2020 poster prize for 2nd Best Chemistry of Life.

NWO ENW KLEIN grant awarded to Koen van den Dries and Michiel Vermeulen

Koen van den Dries will investigate the molecular mechanisms of actin isoform usage in cancer cell migrations. Michiel Vermeulen will search for proteins that interact with adenosine diphosphate ribose chains and play a role in the cellular response to damage to DNA.

28 New genes identified as cause of severe developmental disorders

Christian Gilissen & Laurens van de Wiel with GeneDx and the Wellcome Sanger Institute, have published a major study in the scientific journal Nature, showing the need to bring data together. 

Online conference offers advantages for scientists

Flying around the world for every congress is outdated. Scientists can now choose for a more environmentally conscious option. Published in 'De Volkskrant', Radboudumc researchers Teun Bousema, Estel Collado and Julie Verhoef argue that the online congress can offer serious advantages.

Metakids-UMD grant for Purva Kulkarni

The Metakids foundation has awarded 220.575 Euro to support the establishment of a multi-omics biomarker platform within the United for Metabolic Disease (UMD) consortium.

UMCs work together on the FAIRification of patient registries

It has become easier for scientists working with rare diseases to exchange research data. By researchers from Radboudumc and Amsterdam UMC, a rare disease registry codebook has been created. The codebook facilitates data exchange between institutions with different electronic data capture software.

The new front line: big data podcast

What role do big data and technology play in the fight against corona? What data can help save lives? How do you ensure that your personal health data is used safely? Among others, Peter-Bram 't Hoen explains.

MetaDome highly accessed

MetaDome was recently recognized as one of the most accessed articles of 2018-2019 in Human Mutation. The MetaDome was a project developed by Laurens van de Wiel, Christian Gilissen, and Gert Vriend.

The ICI Amsterdam-Leiden-Nijmegen cancer vaccine consortium

The Chemical Immunology group from Martijn Verdoes, theme Nanomedicine, joined forces with two Organic Chemistry groups and a Chemical Biology group from Leiden University, and Immunology groups at the AmsterdamUMC and the LUMC to form a consortium to develop new cancer vaccines.

Guiding the surgeon real-time tumor visualization during surgery

Incomplete excision of tumor tissue negatively affects the prognosis of the patient. RIHS researcher Mark Rijpkema and colleagues are working on the development of new dual-labeled tracers and currently are implementing this into the clinic.

Prinses Beatrix Spierfonds grant to investigate patient stratification in myotonic dystrophy

RIMLS researchers Rick Wansink and Roland Brock, both theme Nanomedicine, received a € 280,000 grant from the Prinses Beatrix Spierfonds.

RIMLS PhD retreat registration is open

Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.

'Stofwisselkracht' grant for Paola de Haas and Alessandra Cambi

Paola de Haas and Alessandra Cambi, theme Nanomedicine, have recently been awarded a grant from ‘Stichting Stofwisselkracht’ for their project entitled “Identification of immune-related symptoms in Congenital Disorders of Glycosylation”.

RIMLS awards call for nominations

RIMLS awards several prizes to stimulate and honor our (young) researchers. Please find here an overview of the upcoming awards. Deadline 12 December 2019.

Podosome nanoscale architecture redefined

Koen van den Dries and Alessandra Cambi, theme Nanomedicine, revealed how the nanoscale architecture of podosomes enables dendritic cells to protrude and sense their extracellular environment. They have published their results in Nature Communications.

A personal touch of Mariya Chernyavska

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Mariya Chernyavska.

KWF Roadshow 11 November 2019

In which way(s) can KWF provide optimal support to oncological research and care? How can we maximize impact on our investments? These questions are pivotal in Ambition 2030: the vision that KWF developed in close cooperation with stakeholders in the oncological field.

A personal touch of Lise Ripken

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Lise Ripken.

RIMLS 25 years jubilee festival The Future is Yesterday

Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...

Towards molecular therapies for Myotonic Dystrophy

ReCognitION, a new 1.3 M€ European project under the leadership of Peter-Bram ‘t Hoen, Baziel van Engelen and Jeffrey Glennon, was kicked-off in Gent.

MMD Lecturer of the year award for Alessandra Cambi

At their annual MMD symposium, Alessandra Cambi, theme Nanomedicine, was chosen as lecturer of the year 2018-2019 of the Top Master "Molecular mechanisms of disease". 

RIMLS PhD grants awarded to eight RIMLS (j)PI's

Recently, RIMLS held an internal call for Radboudumc junior researcher (PhD) positions. Congratulations for all the awardees and all the best in conducting the research projects.

H2020 grant for a new EATRIS flagship project on personalised medicine

EATRIS obtained funding for a new flagship project for sustainability and personalised medicine: EATRIS-Plus. Alain van Gool, Peter-Bram ‘t Hoen and Ariaan Siezen are co-PI’s and receive approximately 550 k€ from this 5M€ Horizon2020 infrastructure development grant.

Patient trust and participation in cell biological research

Alessandra Cambi and Gert Olthuis discuss key ethical issues inherent in the development and the value of building trust and trustworthiness.

Front cover Human Mutation

The MetaDome web server build to interpret genetic variants based on genetic tolerance and homologous protein domains is featured on the Cover of Human Mutation. MetaDome was developed by Laurens van de Wiel, Coos Baakman, Daan Gilissen, Joris Veltman, Gert Vriend and Christian Gilissen,

NWO grant to develop new biomaterials for improved regeneration of bone defects

Sander Leeuwenburgh, theme Reconstructive and regenerative medicine, and Roland Brock, theme Nanomedicine, were recently awarded with a grant of 581 k€ by NWO, domain Applied & Engineering Sciences, to develop new biomaterials for improved regeneration of bone defects.

Three VIDI grants for RIMLS researchers

Matthijs Jore, Daniele Tauriello and Johannes Textor are each to receive up to 800,000 euros to develop an innovative research theme and to build up their own research group. NWO is awarding the Vidi grant as part of the Innovational Research Incentives Scheme.

ERC Proof of Concept grant for Mangala Srinivas

Mangala Srinivas, theme Nanomedicine, received an ERC Proof of Concept grant 2019-1 for her project entitled: 'Ex vivo cell labeling for in vivo imaging applied to cell therapy'.

Understanding the inner architecture of a nanomedicine

The group of Roland Brock, theme Nanomedicie, and colleagues, used superresolution microscopy to quantitatively image the structure and composition of peptide – messenger RNA nanoparticles and related this to biological activity. They have published their findings in Nano Letters.

Internal KWF review procedure 2019

In agreement with the existing policy the research board and Radboudumc Center for Oncology have decided to continue with the mandatory internal review procedure for KWF grant applications.

Call for RIMLS Junior Researcher 2020

In 2020 funding will be made available for 8 RIMLS Junior Researcher projects. The call for these PhD grants is now open.

Publication on nanoparticle imaging agent

Mangala Srinivas, theme Nanomedicine, showed in Advanced Functional Materials that nano‐particles (radius 100 nm), are suitable for long‐term in vivo ultrasound in combination with 19F MRI and fluorescence.

Official charity status Young Academy of Europe

Registration as a charity establishes the official status of the YAE and enables it to start raising funds and receive donations, and to grow further as a community and a positive force for influencing scientific policy throughout Europe.

The first Radboud Nanomedicine community networking event

On 7 February 2019 the first Radboud Nanomedicine community networking event took place. The goal of the event was to bring together all those working in the field of nanomedicine at the Radboud University and Radboudumc, irrespective of the theme in which the research is performed.