Reconstructive and regenerative medicine About themeThe theme focuses on the development and clinical translation of innovative diagnosis and reconstructive therapies, including regenerative medicine and nanomedicine, towards personalized care and cure of patients needing reconstructions of lost or damaged tissues. read more
Lines of research
Surgeon of the futureWithin this subtopic, research focuses on: (i) clinical expertise for complex problems and rare diseases in combination with basic and clinical research that will shape the future together with patients; (ii) with emerging robot- and data-driven techniques the focus is shifting to minimally invasive surgery (e.g. patient-tailored surgery through the use of advanced procedure planning and assistance by advanced imaging modalities and artificial intelligence; (iii) this constantly changing medical environment requires adaptation of daily clinical practice, and training of a new type of surgeon using new procedures and materials. Theme RRM uses the concept of the ‘Surgeon of the future’ and develops and implements technologies that revolutionize surgical procedures, including patient-specific virtual operation planning, 3D-printed anatomical models, simulated reconstructions, new animal models for surgical procedures and material evaluation, and the use of augmented reality.
Materials to support self-healingThe research within this line focuses on: (i) cell-free implants and prostheses; (ii) functionalized material and smart scaffolds; (iii) 3D technologies. While the human body already contains an extraordinary capacity for natural self-repair, the removal of diseased or damaged tissues, organs, and body parts results in both physical ‘gaps’ and defects in function and appearance that need to be restored. Our theme develops tools that support and instruct the body’s endogenous healing and regenerative capacity to replace structural anomalies and lost or damaged tissues, which includes prosthetic tools, smart and patient-tailored scaffolds, implants, and biomaterials. The theme aims to apply acellular biomaterials (where possible) or intra-operatively prepared cellular constructs as these are easier to translate to the clinic than complex biomaterials.
Regrowing tissues, organs and limbsHere research includes: (i) functional tissue regeneration; (ii) organ regeneration; (iii) limb reconstructions. Self-healing is the regeneration of functional tissues and organs. In Europe, thousands of people are on a waiting list for organ transplantation (e.g. heart, kidney, liver, lungs), and often die prior to organ transplantation because of the shortage in healthy donor organs and the difficulty in finding a good match. Theme RRM combines expertise towards making several essential steps to fulfil the true potential of reconstructive and regenerative medicine. The theme combines all necessary know-how to take a leading position in functional restoration of underdeveloped tissues and missing limbs. Working towards normal functional outcome of limb replacement and additional innovations in a realistic matter.
News, events, impact and organization
Centers of clinical expertiseThis theme is affiliated with nationally acknowledged Radboudumc expertise centers. Information might be only available in Dutch.
The daily management of the theme Reconstructive & Regenerative Medicine is executed by the coordinating team, consisting of the following members:
Harry van Goor (chair)
Wout Feitz (Urology)
Nico Verdonschot (Orthopedics)
Willeke Daamen (Biochemistry)
Jeroen van den Beucken (Biomaterials)
Clasien Oomen (scientific policy advisor)