News

Increase radio- and immunotherapy efficacy by targeting hypoxia

In a paper recently accepted by Clinical Cancer Research, Daan Boreel, together with Paul Span, Sandra Heskamp, Gosse Adema and Jan Bussink, reviews the therapeutic potential of decreasing the lack of oxygen (hypoxia) often found in solid tumors.

RIMLS online award ceremony proudly presenting the winners

In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony. 

Tunable hybrid matrices drive epithelial morphogenesis

In an article in Advanced Science, Paul Span, Mirjam Zegers and colleagues apply synthetic polyisocyanide hydrogels to induce a full spectrum of morphologies in epithelial cells.

Dutch Cancer Society grant for AI research on premalignancies of the Fallopian tube

The Dutch Cancer Society decided to award the project ‘Deep learning for improved detection of premalignant lesions in the Fallopian tube’ with a grant of 493K euros. The project is a collaboration between the Radboudumc departments of Pathology, Obstetrics and and Mayo Clinic Florida (US).

Collective invasion induced by autocrine purinergic loop through connexin-43 hemichannels

Peter Friedl, Paul Span and Antoine Khalil show in Journal of Cell Biology that breastcancer cells release purines into the extracellular space via connexin-43 hemichannels to control collective invasion.

Mireille Broeders appointed full Professor of Personalized Cancer Screening

Mireille Broeders of the Department for Health Evidence has been appointed full professor of Personalized Cancer Screening. This appointment became effective on 1 May 2020.

Grant for early detection of ovarian cancer

The Department of Biochemistry (Toin van Kuppevelt/Willeke Daamen), together with the Department of Gynecology, has been awarded a grant of 144 kEuro for the development of an assay for the early detection of ovarian cancer.

First graduation in 'de Aula' in accordance with new guidelines

On Wednesday 3 June, the first Radboudumc-graduation took place in 'de Aula' in accordance with the new RIVM guidelines.

Guiding the surgeon real-time tumor visualization during surgery

Incomplete excision of tumor tissue negatively affects the prognosis of the patient. RIHS researcher Mark Rijpkema and colleagues are working on the development of new dual-labeled tracers and currently are implementing this into the clinic.

RIMLS PhD retreat registration is open

Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.

Supplemental MRI screening for women with extremely dense breast tissue

In the New England Journal of Medicine, the DENSE trial study group including RIHS researchers Ritse Mann and Nico Karssemeijer showed that additional MRI after the nationwide breast screening, reduces interval breast cancer in women with extremely dense breast tissue.

Synopsis of the European Breast Guidelines on organized breast cancer screening programs

In Annals of internal medicine Mireille Broeders and colleagues from the European Commission Initiative on Breast Cancer (ECIBC) Guidelines Development Group provide a synopsis of recommendations on organized breast cancer screening programs for women aged 40 to 75 years.

Awarded KWF grants for Radboudumc researchers

KWF is investing 2.7 million euros in five different studies at Radboudumc. The awards are part of the new round of funding by DCS, in which over 34 million euros will be granted to Dutch cancer research. We congratulate our researchers with this funding and wish them success with their great work.

ERC Consolidator Grant for Bousema and Sechopoulos

Teun Bousema and Ioannis Sechopoulos each receive an ERC Consolidator Grant of around two million euros. This European research subsidy will enable them to carry out research for the next five years.

Exploration meeting Academic Alliance on Oncology

Within the Academic Alliance, the Maastricht UMC+ and Radboudumc are already working together in several areas. And this is happening in more and more fields. On 27 November researchers from both umc's met during the fourth Exploration meeting, this time with the theme: Oncology.

RIMLS awards call for nominations

RIMLS awards several prizes to stimulate and honor our (young) researchers. Please find here an overview of the upcoming awards. Deadline 12 December 2019.

Technology for Oncology II grant application funded

The grant application called "aiREAD – Accurate and Intelligent Reading for EArlier breast cancer Detection” by project leader Ioannis Sechopoulos, has been selected for funding under the NWO TTW – KWF Kankerbestrijding – Top Sector LSH Partnership “Technology for Oncology II”.

3D breast ultrasound elastography to improve breast cancer detection

One out of seven women will be diagnosed with breast cancer during their life. Early detection of breast cancer is important to increase the survival rate. Gijs Hendriks graduated recently on a new technique, 3D elastography, to detect breast cancer better.

KWF Roadshow 11 November 2019

In which way(s) can KWF provide optimal support to oncological research and care? How can we maximize impact on our investments? These questions are pivotal in Ambition 2030: the vision that KWF developed in close cooperation with stakeholders in the oncological field.

RIMLS 25 years jubilee festival The Future is Yesterday

Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...

Artificial intelligence for renal tissue assessment

Meyke Hermsen and Jeroen van der Laak, present an alternative approach, featuring a convolutional neural network for multi-class segmentation of periodic acid–Schiff-stained kidney tissue sections. Their work was published in the Journal of the American Society of Nephrology.

European Commission Initiative on Breast Cancer (ECIBC) Guidelines

In Annals of internal medicine Mireille Broeders and colleagues from the ECIBC Guidelines Development Group described the methods used to develop person-centered evidence-based recommendations for screening and diagnosis of breast cancer.

Bart Kiemeney finishes 1st in the Tour and raises thousands of euros

With over €47,000 on the counter, Kiemeney can see the Tour de France as a great success.

Internal KWF review procedure 2020

In agreement with the existing policy the research board and Radboud Center for Oncology have decided to continue with the mandatory internal review procedure for KWF grant applications.

VIDI grant for Ritse Mann

Ritse Mann, theme Women's cancers, receives up to 800,000 euros to develop an innovative research theme and to build up his own research group. NWO is awarding the Vidi grant as part of the Innovational Research Incentives Scheme.

Universal tumor BRCA1/2 testing of ovarian cancer

Marjolijn Ligtenberg, Janet Vos and Nicoline Hoogerbrugge, assessed the feasibility of a workflow for universal tumor DNA BRCA1/2 testing of all newly diagnosed OC patients as prescreen for PARPi treatment and cancer predisposition testing. They have published their findings in the JNCI.

Internal KWF review procedure 2019

In agreement with the existing policy the research board and Radboudumc Center for Oncology have decided to continue with the mandatory internal review procedure for KWF grant applications.

Jeroen van der Laak awarded as Nathan Kaufman timely topics lecturer

Jeroen van der Laak awarded as Nathan Kaufman timely topics lecturer 2019 at the annual meeting of the United States and Canadian Academy of Pathology (USCAP).

The impact of menstrual symptoms on everyday life

Bertho Nieboer and colleagues described the results of a survey among 42,879 women about the impact of menstrual symptoms on everyday life in the American Journal of Obstetrics and Gynecology.

Francesco Ciompi and Jeroen van der Laak have been awarded a KWF grant

Francesco Ciompi and Jeroen van der Laak have been awarded a KWF grant of € 200K with € 150K for Radboudumc for the PROACTING project (PRedicting neOAdjuvant Chemotherapy Treatment response with deeplearnING).

Call for RIMLS Junior Researcher 2020

In 2020 funding will be made available for 8 RIMLS Junior Researcher projects. The call for these PhD grants is now open.

Artificial intelligence vs. 101 radiologists for breast cancer detection

In an article appearing in the journal of the National Cancer Institute, Ioannis Sechopoulos and colleagues showed that current artificial intelligence systems can detect breast cancer in mammograms as well as a breast radiologists.

Determinants for variation in Integrated Head and Neck Cancer

In National Comprehensive Cancer Network Lydia van Overveld and Rosella Hermens described the quality of current integrated head and neck cancer care using evidence-based quality indicators, the variation between Dutch hospitals, and the influence of patient and hospital characteristics.

Ioannis Sechopoulos elected Fellow of the American Association of Physicists in Medicine

Ioannis was named Fellow of the AAPM due to his distinguished contributions to medical physics and the esteem in which he is held by his peers.

RIMLS awards festival Twelve winners

In 5 categories RIMLS young researchers received an award and bonus during the New Year's drinks. See all photo's.

Breast cancer screening KWF grant

KWF has granted a sum of more than 730,000 euros to the research consortium of Mireille Broeders, including among others Radboud colleagues Jos van Dijck, Ritse Mann, Nico Karssemeijer, and Jonas Teuwen.

Internal KWF review procedure 2019

In agreement with the existing policy the research board and Radboud Center for Oncology have decided to continue with the mandatory internal review procedure for KWF grant applications.

Awarded KWF grants for Radboudumc researchers

The Dutch Cancer Society (KWF) has awarded 8 grants to Radboudumc researchers. We congratulate them with this funding and wish them success with their great work.

René Vogels Stichting travel grant for Pieter Roelofs

Pieter Roelofs received the award in order to perform a work visit to prof. Reuben Harris’ lab at the University of Minnesota, USA.

H2020 grant for Computational Pathology

Jeroen van der Laak and Francesco Ciompi have been awarded an ICT12 H2020 grant of € 4.3M, with € 675K for Radboudumc.

Report of the 12th New Frontiers symposium Big data, better healthcare? - 1 November 2018

Examples from the application of deep learning to image reading in pathology and radiology and the application of network medicine to monitor infectious disease outbreaks or collective mood states using twitter data showed the huge potential of big data approaches for building better healthcare.

Report of the 12th New Frontiers symposium Better care, network care? - 2 November 2018

No easy answers at this symposium last Friday, only challenges that can be overcome if we succeed in 5 things. First and most radically, put patients in the center of healthcare. Second, start with assessing what the local population needs and not what local professionals have to offer.

Public evening 'Dag Dokter'

Two Radboud Science Awards for RIHS researchers

Jeroen van der Laak, Geert Litjens and Thijs Eijsvogels have been awarded the Radboud Science Award 2018. The awardees receive the award for the quality of their scientific research.

Last chance to register for ENABLE 2018

The 2nd ENABLE symposium entitled “The promise of future medicine: from research to therapy” will be hosted in Copenhagen, from 7 - 9 November. Don’t miss out, registration closes 30 September.

Internal KWF review procedure December 2018

First deadline is approaching. 24 October 2018 is the deadline for the registration of new applications.

Influence of breast compression pressure in mammography screening

In Breast Cancer Research Nico Karssemeijer, Ritse Mann and colleagues presented a study in which they found that less breast cancers are detected when breasts are compressed too firm in mammography.

Identification of dozens of ovarian cancer genes

In Cancer Research, a global consortium in which Leon Massuger and Bart Kiemeney participate describes the identification of dozens of low-penetrance genes at genomic loci that were previously associated with ovarian cancer.

Screening and vaccination to prevent cervical cancer

Interview Willem Melchers, head of laboratory for clinical microbiology and Ruud Bekkers gynecological oncologist Radboudumc and Catharina Hospital Eindhoven in Pulse Media.

Personalised risk-based breast cancer screening and primary prevention

Linda Rainey, Mireille Broeders, Daniëlle van der Waal, and colleagues published three papers last month on the future implementation of risk-based breast cancer screening and prevention.