Vacancies 101381-PhD-candidate-Retina-on-Chip-Modeling-and-Treating-Eye-diseases-in-a-dish

Will you be our new colleague?

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About the position

  • 36 hours per week
  • Temporary
  • 4 years
  • Salary scale 10A
  • min € 2495 - max € 3196 gross per month for full-time employment
  • Deadline: 10 August 2021
  • Date first interview: 18-20 August 2021

#weareradboudumc, what about you?


Job description

The eye is the window to the world around us. Losing vision either early or late in life is a significant burden for patients. Nowadays, molecular therapies for eye conditions are at the forefront of personalized medicine development. However, the eye is a very complex and specialized organ and...

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Job description

The eye is the window to the world around us. Losing vision either early or late in life is a significant burden for patients. Nowadays, molecular therapies for eye conditions are at the forefront of personalized medicine development. However, the eye is a very complex and specialized organ and the lack of relevant and robust models hampers the progress in understanding the disease mechanisms and designing effective treatments. Will you join our group?

In your PhD project you will generate and investigate several retinal cells using from induced pluripotent stem cells from patients suffering from different diseases to find proper measurable readouts. We aim to create a cellular system based on iPSC human cells to generate a retina-on-a-chip to understand disease mechanism(s) and assess therapeutics. 

This work will be done in collaboration with the University of Twente and two industrial partners. This project is funded by the Partnership programme Human Measurement models 2.0 for research into the treatment and/or prevention of diseases is funded by the Association of Collaborating Health Foundations (SGF) with a PPP allowance made available by Health~Holland (Top Sector Life Sciences & Health), by ZonMw and NWO Domain AES, and Stichting Proefdiervrij.

Tasks and responsibilities

  • Plan and perform scientific in vitro and in vivo experiments in an independent manner.
  • Critically analyze data.
  • Take a leading role in writing manuscripts.
  • Present data at local, national and international scientific meetings.
  • Supervise MSc and/or BSc students.


Department

You will be positioned within the “Molecular Therapies for Neurometabolic Diseases” group led by Dr. Alex Garanto, that aims to develop models and therapeutic interventions for inherited metabolic and eye diseases. There will be close collaboration with the group of “Molecular Therapies for...

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Department

You will be positioned within the “Molecular Therapies for Neurometabolic Diseases” group led by Dr. Alex Garanto, that aims to develop models and therapeutic interventions for inherited metabolic and eye diseases. There will be close collaboration with the group of “Molecular Therapies for Inherited Eye Diseases” led by Dr. Rob Collin, with whom we share lab and expertise. There will also be collaborations with the Translational Metabolic Laboratory and the Department of Ophthalmology. In addition, you will work with a Research Technician assigned to this specific project, and with colleagues at the University of Twente.

You will be affiliated with the Department of Pediatrics, and will conduct the experimental work in the Department of Human Genetics of the Radboudumc in Nijmegen. Radboudumc is internationally renowned for its research and diagnostics on a variety of genetic disorders and the impact of personalized medicine. Both departments offer an exciting working environment with enthusiastic people from many parts of the world, providing ample critical mass and a stimulating, collaborative atmosphere for high quality research.

Research Institutes
At the moment there are more than 1,300 PhD candidates at our medical hospital. This number includes PhD candidates on our pay roll as well as external candidates (those employed somewhere else but researching on our premises).

  • Radboud Institute for Health Sciences: ± 700
  • Radboud Institute for Molecular Life Sciences: ± 400
  • Donders Center for Medical Neurosciences: ± 200
Read what it is like to do a PhD at the Radboud University Medical Center.

Radboudumc
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc


Profile

We are looking for a PhD candidate who has a strong ambition to succeed in science and is result-oriented. You should possess a critical scientific attitude and should be able to work both independently as well as in a team.

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Profile

We are looking for a PhD candidate who has a strong ambition to succeed in science and is result-oriented. You should possess a critical scientific attitude and should be able to work both independently as well as in a team.

Furthermore:

  • MSc degree in Molecular Life Sciences or a related field.
  • A solid theoretical background in molecular and cell biology.
  • Hands-on experience with standard molecular techniques such as PCR, cloning, RT-PCR, western blotting, cell culture and stem cell technology.
  • Experience with electrophysiology and/or molecular therapy is considered a strong plus.
  • Strong communication skills (both orally and in writing) and a high English level.

Let's meet


Terms of employment

The anticipated starting date is 15th of October 2021. Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. But there is more. Our secondary terms of employment are impressive. These are fully tailored to you...

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Terms of employment

The anticipated starting date is 15th of October 2021. Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. But there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.
 

  • In addition to your monthly salary and an annual vacation allowance of 8%, you will receive an end-of-year bonus of 8.3%.
  • If you work irregular hours, you will receive an allowance.
  • As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
  • Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
  • You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the Cao UMC.


Application procedure

The following should be included in your application: CV, strong motivation letter and names and contact information of two references. We would like to receive your application before 10 August 2021. We will then contact you shortly.The first interview round takes place on 18-20 August 2021...

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Application procedure

The following should be included in your application: CV, strong motivation letter and names and contact information of two references. We would like to receive your application before 10 August 2021. We will then contact you shortly.The first interview round takes place on 18-20 August 2021 (online) and the second interview round will take place on 8-14 September 2021 (physically). We would appreciate it if you would take this into account.

What else can you expect?

When you begin employment, we will request a certificate of conduct (VOG) and, depending on the position, you may be screened. You do not need to do anything for this; we will inform you later. 
 
Radboud university medical center is an employer that welcomes everyone. Every colleague brings valuable experience, expertise, and creativity. We believe in the benefits of a diverse and inclusive organization. #weareradboudumc

Read more about our application procedure or take a look at the frequently asked questions
 
We are recruiting for this vacancy ourselves. We only accept applications directly from the applicants themselves, but intermediaries are welcome to share our vacancies in their networks.​


Contact

All additional information about the vacancy can be obtained from Dr. Alex Garanto . Use the Apply button to submit your application.

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Contact

All additional information about the vacancy can be obtained from Dr. Alex GarantoUse the Apply button to submit your application.

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