Vacancies 109321-Postdoc-Innovative-methods-for-personalized-prediction-based-on-data-from-rare-cancers

About the position

  • 32-36 hours per week
  • Temporary
  • 3 years
  • Salary scale 10
  • Fulltime: min € 2986 - max € 4707 gross per month
  • Apply before 14 February 2022
  • Date first interview: 28 February 2022

#weareradboudumc, what about you?


Job description

We offer an exciting postdoc position for a (mathematical) statistician or statistical physicist to develop methodology in the field of personalized prediction, based on data from rare cancer patients and in particular from patients with salivary gland cancer. The project research group consists...

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Job description

We offer an exciting postdoc position for a (mathematical) statistician or statistical physicist to develop methodology in the field of personalized prediction, based on data from rare cancer patients and in particular from patients with salivary gland cancer. The project research group consists of researchers from biostatistics, statistical physics and medical oncology. Will you join us? 

We aim to find a researcher who is interested in developing the new mathematical methodology, as well as applying them to cancer data in collaboration with researchers from oncology. The position offers the opportunity to build a scientific path in an area of important societal interest and potential impact as it supports improving treatments for patients suffering from rare cancers.

In research into rare cancers only small data sets are typically available. When using such small data sets for prediction, the risk of overfitting in the models used is high. This limits severely the ability to infer statistically significant patterns in these data, patterns which might have suggested novel treatments. Pooling data from different institutions could alleviate the situation, but is in practice challenging due to regulatory and logistical problems. The project is financed by the Hanarth Fund.

You will work on two complementary routes for confronting the challenges of small data sets for rare cancers.

  • The first is to focus on more powerful techniques for inference that are better able to cope with small sample sizes, without overfitting.
  • The second route is to design and improve machine learning algorithms that circumvent the need for data pooling at one location for analysis by 'cycling’ around medical data repositories with small data sets (federated learning).
Data on salivary gland cancer patients will be analyzed with the proposed methods.


Department

Within the project 'Innovative methods for personalized prediction based on data from rare cancers' there will be a strong collaboration between the section Biostatistics of the Department for Health Evidence (Dr. Marianne Jonker and Prof. dr. Kit Roes), Department of Medical Oncology (Prof.dr...

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Department

Within the project 'Innovative methods for personalized prediction based on data from rare cancers' there will be a strong collaboration between the section Biostatistics of the Department for Health Evidence (Dr. Marianne Jonker and Prof. dr. Kit Roes), Department of Medical Oncology (Prof.dr. Carla van Herpen), both in the Radboud university medical center and the Department of Biophysics, University of Nijmegen  (Prof.dr. Ton Coolen).

The section Biostatistics (Radboudumc) has a strong track record in statistical methodology for clinical research, with a focus on innovative designs and analysis of clinical research for personalized medicine and rare disorders and on prediction.

The department of Medical Oncology (Radboudumc) and in particular the group of Carla van Herpen is focused on better care and on the development of new personalized and innovative treatments for patients with salivary gland cancer, a rare cancer. Furthermore she is one of the founders of the Dutch rare Cancer Platform (DRCP).

The Physics of Machine Learning and Complex Systems group in the department of Biophysics (University of Nijmegen) focuses on the development and application of novel mathematical methods for solving complex problems at the interface with the medical sciences.

Radboudumc
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc


Profile

You have a PhD degree in (mathematical) statistics, statistical physics or a related field. Furthermore you have scientific interest in medical applications, and in particular in rare cancers. Knowledge of the field of survival analysis will be an advantage. You also have well-developed social...

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Profile

You have a PhD degree in (mathematical) statistics, statistical physics or a related field. Furthermore you have scientific interest in medical applications, and in particular in rare cancers. Knowledge of the field of survival analysis will be an advantage. You also have well-developed social skills directed to working in multidisciplinary teams.

Let's meet


Terms of employment

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At...

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Terms of employment

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.

  • In addition to your monthly salary and an annual vacation allowance of 8%, you will receive an end-of-year bonus of 8.3%.
  • If you work irregular hours, you will receive an allowance.
  • As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
  • Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
  • You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
 
In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the CAO UMC.


Application procedure

Please send a motivation letter motivation letter (max. 1 page), a CV (including a publication list), and contact information of at least two professional references. We would like to receive your application before 14 February 2022. We will then contact you shortly. The first interview round...

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Application procedure

Please send a motivation letter motivation letter (max. 1 page), a CV (including a publication list), and contact information of at least two professional references. We would like to receive your application before 14 February 2022. We will then contact you shortly. The first interview round takes place on 28 February 2022. We would appreciate it if you would take this into account.

What else can you expect?

When you begin employment, we will request a certificate of conduct (VOG) and, depending on the position, you may be screened. You do not need to do anything for this; we will inform you later. 
 
Radboud university medical center is an employer that welcomes everyone. Every colleague brings valuable experience, expertise, and creativity. We believe in the benefits of a diverse and inclusive organization. #weareradboudumc

Read more about our application procedure or take a look at the frequently asked questions
 
We are recruiting for this vacancy ourselves. We only accept applications directly from the applicants themselves, but intermediaries are welcome to share our vacancies in their networks.​


Contact

All additional information about the vacancy can be obtained from Dr. Marianne Jonker , Assistant Professor Health Evidence or from Prof. dr. Ton Coolen , Full Professor. Use the Apply button to submit your application.

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Contact

All additional information about the vacancy can be obtained from Dr. Marianne Jonker, Assistant Professor Health Evidence or from Prof. dr. Ton Coolen, Full Professor.  Use the Apply button to submit your application.

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