Vacancies 110421-PhD-Candidate-ZOEMBA-ZOektocht-naar-Erfelijke-MetaBole-Aandoeningen

About the position

  • 36 hours per week
  • Temporary
  • 4 years
  • Salary scale 10A
  • Fulltime: min € 2570 - max € 3271 gross per month
  • Apply before 3 February 2022

#weareradboudumc, what about you?


Job description

The ZOEMBA (“ZOektocht naar Erfelijke MetaBole Aandoeningen”) study is a national multicentre study, led by the ‘United for Metabolic Diseases’ (UMD) consortium. The study focusses on the identification of the genetic etiology underlying suspected inherited metabolic disorders for patients who...

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Job description

The ZOEMBA (“ZOektocht naar Erfelijke MetaBole Aandoeningen”) study is a national multicentre study, led by the ‘United for Metabolic Diseases’ (UMD) consortium. The study focusses on the identification of the genetic etiology underlying suspected inherited metabolic disorders for patients who have exhausted standard of care technologies. Obtaining a diagnosis for patients is of utmost importance as it paves the way to personalized therapeutic opportunities. Will you join us? 

The aim of this PhD project is to analyse and interpret existing exome and genome data of 350 patients (and their families) and integrate these with other -omics technologies such as metabolomic and transcriptomic datasets, to identify the possible cause of disease. Follow-up functional studies will be performed to validate pathogenicity of the identified variants to establish a conclusive diagnosis for these patients. The obtained results will subsequently serve as input to define the most efficient diagnostic strategy, which will be translated into guidelines for routine diagnostic care.

The project is part of an interdisciplinary collaboration between clinic and research, as well as, genetic and metabolic laboratories. You closely interacts with the research groups of Prof. dr. Clara van Karnebeek (Amsterdam UMC) and colleagues at the Translational metabolic laboratory (RUMC). You will be hosted at the Human genetics Department of the Radboudumc, under supervision of Prof. dr. Lisenka Vissers, Dr. Machteld Oud, and embedded in the Donders Institute for Brain, Cognition and Behaviour of the Radboud University Medical Center.

Tasks and responsibilities

  • Will be responsible for analysing and interpreting large omics datasets (exomes, genomes, transcriptomes) of patients with a metabolic disease.
  • Design and perform scientific research in a stimulating environment.
  • Work in a local team with PhD students, scientists and clinicians, but also at national level with other institutes within the Netherlands.
  • Publish the obtained results in (peer-reviewed) scientific journals and present the data at (inter)national scientific conferences.
  • Finish the PhD track with a scientific dissertation.


Department

The research project will be based at the department of Human Genetics of the Radboudumc. We provide a stimulating work environment within a group of enthusiastic clinical and non-clinical researchers with a strong national and international research network. The department houses a range of top...

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Department

The research project will be based at the department of Human Genetics of the Radboudumc. We provide a stimulating work environment within a group of enthusiastic clinical and non-clinical researchers with a strong national and international research network. The department houses a range of top researchers in the area of Medical Genetics and has a strong track record, with recent publications in high-impact journals (Science, Nature, Nature Genetics). The combined infrastructure is state-of-the-art including innovative genetic technologies (Next-Generation Sequencing and affiliated omics) and a wide range of cellular functional assays.

At the moment there are more than 1,300 PhD candidates at our medical hospital. This number includes PhD candidates on our pay roll as well as external candidates (those employed somewhere else but researching on our premises).

  • Radboud Institute for Health Sciences: ± 700
  • Radboud Institute for Molecular Life Sciences: ± 400
  • Donders Center for Medical Neurosciences: ± 200
Read what it is like to do a PhD at the Radboud University Medical Center.

Radboudumc
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc


Profile

We are looking for a PhD candidate with a n academic degree (MSc) in molecular life sciences, biomedical sciences or a related discipline. You have a strong background in molecular genetics. Furthermore: Affinity with bioinformatic analyses and working with big data. Affinity with basic molecular...

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Profile

We are looking for a PhD candidate with an academic degree (MSc) in molecular life sciences, biomedical sciences or a related discipline. You have a strong background in molecular genetics. Furthermore:

  • Affinity with bioinformatic analyses and working with big data.
  • Affinity with basic molecular laboratory work.
  • Highly motivated to work in an interdisciplinary environment at the cutting edge of science.
  • Excellent interpersonal and communication skills and is willing to work flexibly.

Let's meet


Terms of employment

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At...

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Terms of employment

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.

  • In addition to your monthly salary and an annual vacation allowance of 8%, you will receive an end-of-year bonus of 8.3%.
  • If you work irregular hours, you will receive an allowance.
  • As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
  • Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
  • You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
 
In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the Cao UMC.


Application procedure

We would like to receive your application before 3 Februari 2022. We will then contact you shortly.

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Application procedure

We would like to receive your application before 3 Februari 2022. We will then contact you shortly.

What else can you expect?

When you begin employment, we will request a certificate of conduct (VOG) and, depending on the position, you may be screened. You do not need to do anything for this; we will inform you later. 
 
Radboud university medical center is an employer that welcomes everyone. Every colleague brings valuable experience, expertise, and creativity. We believe in the benefits of a diverse and inclusive organization. #weareradboudumc

Read more about our application procedure or take a look at the frequently asked questions
 
We are recruiting for this vacancy ourselves. We only accept applications directly from the applicants themselves, but intermediaries are welcome to share our vacancies in their networks.​


Contact

All additional information about the vacancy can be obtained from Prof. dr. Lisenka Vissers , dr. Machteld Oud , and Prof. dr. Clara van Karnebeek . Use the Apply button to submit your application.

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Contact

All additional information about the vacancy can be obtained from Prof. dr. Lisenka Vissers, dr. Machteld Oud, and Prof. dr. Clara van KarnebeekUse the Apply button to submit your application.

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