Vacancies 121381-Postdoc-Novel-immunotherapeutic-targeting-of-B-cell-malignancies-and-effects-on-neutrophils

About the position

  • 36 hours per week
  • Temporary
  • 3 years
  • Salary scale 10
  • Fulltime: min € 3047 - max € 4800 gross per month
  • Apply before 7 September 2022

#weareradboudumc, what about you?


Job description

In this project, we will study novel CD37 antibodies (‘’hexabodies’’) in their cytotoxic capacity in human lymphomas. Secondly, we aim to identify the underlying molecular mechanism by investigating downstream signaling and CD37 organization at the cell surface of lymphomas and primary immune... read more

Job description

In this project, we will study novel CD37 antibodies (‘’hexabodies’’) in their cytotoxic capacity in human lymphomas. Secondly, we aim to identify the underlying molecular mechanism by investigating downstream signaling and CD37 organization at the cell surface of lymphomas and primary immune cells (neutrophils) using advanced microscopy techniques. Will you join our team? 

Tetraspanins belong to the transmembrane-4-superfamily that consists of small (20-50 kDa) transmembrane proteins that are abundantly expressed at the cell surface. We discovered that the B cell-specific tetraspanin CD37 is a novel tumor suppressor in lymphoma (de Winde et al. J. Clin.Invest. 2016, Elfrink et al. Blood 2019, Peeters et al. In Press 2022).

Targeting CD37 is currently under clinical investigation in patients with aggressive lymphomas (de Winde et al. Trends in Cancer 2017, Oostindie et al., Blood Cancer J. 2020). This project is supported through the ERC (Consolidator Grant) and in collaboration with Genmab.


Department

Radboud Institute for Molecular Life Sciences ( RIMLS ) in the Netherlands is a leading European research school providing an outstanding research setting within the Radboud University Medical Center. The RIMLS focuses on basic science and its translation into pioneering treatments in the clinic... read more

Department

Radboud Institute for Molecular Life Sciences (RIMLS) in the Netherlands is a leading European research school providing an outstanding research setting within the Radboud University Medical Center. The RIMLS focuses on basic science and its translation into pioneering treatments in the clinic. RIMLS innovations are advanced through technology platforms such as genomics, proteomics, and molecular imaging.

Department of Tumor ImmunologyResearch within the department aims at a better understanding of our immune system using molecular, cell biological and immunological techniques. Our research is centered around dendritic cells, B cells and regulatory T cells which play an important role regulating the immune response. We investigate the interplay between immune and tumor cells within the tumor microenvironment. In addition, we study membrane protein organization at the cell surface of immune cells that is important for signal transduction. An important activity of the department is the translation of basic research into clinical application.

Radboudumc
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc


Profile

Candidates should have obtained a PhD degree in biology/immunology or equivalent. In this project we will combine immunological (tumor cytotoxicity assays, flow cytometry) with cell biological techniques (migration, advanced cell imaging, signal transduction). An extensive immunological/cell... read more

Profile

Candidates should have obtained a PhD degree in biology/immunology or equivalent. In this project we will combine immunological (tumor cytotoxicity assays, flow cytometry) with cell biological techniques (migration, advanced cell imaging, signal transduction). An extensive immunological/cell biological background is therefore important.

Let's meet


Terms of employment

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At... read more

Terms of employment

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.

  • In addition to your monthly salary and an annual vacation allowance of 8%, you will receive an end-of-year bonus of 8.3%.
  • If you work irregular hours, you will receive an allowance.
  • As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
  • Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
  • You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
 
In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the CAO UMC.


Application procedure

We would like to receive your application before 7 September 2022. We will then contact you shortly. read more

Application procedure

We would like to receive your application before 7 September 2022. We will then contact you shortly.

What else can you expect?

When you begin employment, we will request a certificate of conduct (VOG) and, depending on the position, you may be screened. You do not need to do anything for this; we will inform you later. 
 
Radboud university medical center is an employer that welcomes everyone. Every colleague brings valuable experience, expertise, and creativity. We believe in the benefits of a diverse and inclusive organization. #weareradboudumc

Read more about our application procedure or take a look at the frequently asked questions
 
We are recruiting for this vacancy ourselves. We only accept applications directly from the applicants themselves, but intermediaries are welcome to share our vacancies in their networks.​


Contact

All additional information about the vacancy can be obtained from Prof. Annemiek van Spriel, research group leader. We invite you to check the website of the Research group - Immune cell signaling. Use the Apply button to submit your application. read more

Contact

All additional information about the vacancy can be obtained from Prof. Annemiek van Spriel, research group leader. We invite you to check the website of the Research group - Immune cell signaling. Use the Apply button to submit your application.

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