Vacancies 123481-PhD-candidate-Biostatistics

About the position

  • 36 hours per week
  • Temporary
  • 5 years
  • Salary scale 10A
  • Fulltime: min € 2631 - max € 3336 gross per month
  • Apply before 25 October 2022

#weareradboudumc, what about you?


Job description

We are looking for a PhD candidate Biostatistics for our project to investigate and improve the use, uptake and advice on (statistical) model-based design and analysis of dose finding studies required for market approval of targeted therapies. Will you join our team? read more

Job description

We are looking for a PhD candidate Biostatistics for our project to investigate and improve the use, uptake and advice on (statistical) model-based design and analysis of dose finding studies required for market approval of targeted therapies. Will you join our team? 

Modern targeted anti-cancer medication, such as immunotherapy, has shown clear benefits for cancer patients and new products are continuously developed. Their mode of action is fundamentally different from classical therapies, which requires a different approach for early stage clinical trials that aim to determine a safe and effective dose range. The Medicines Evaluation Board aims to be at the forefront for such new approaches in its function to provide companies scientific advice on their development program, as well as assessing the results when submitted for regulatory approval. Against this exciting background,  you investigate and improve the use, uptake and advice on (statistical) model-based design and analysis of dose finding studies required for market approval of targeted therapies. This involves amongst others scientific review of (public) regulatory assessment dossiers and performing statistical simulation studies to compare and improve different dose findings designs.

The project aligns with the Medicines Evaluation Board (agentschap College Beoordeling Geneesmiddelen) research themes “Personalised medicine & biomarkers and data-driven assessment” and  Radboudumc research theme “Personalized health care” and the mission of the Department of Health Evidence to develop and apply methods for prediction and evaluation research. You will be part of scientifically strong teams, both at Radboudumc and the CBG, with a strong track record in drug development, regulatory science and statistics. This is also embedded internationally, with close collaboration across Europe thought the European Medicines Agency, allowing you a strong start for a career in drug development.


Department

You will be employed by the section Biostatistics of the Department of Health Evidence (Nijmegen, the Netherlands). It has a strong track record in statistical methodology for clinical research, with a focus on innovative designs and analysis of clinical research for personalized medicine rare... read more

Department

You will be employed by the section Biostatistics of the Department of Health Evidence (Nijmegen, the Netherlands). It has a strong track record in statistical methodology for clinical research, with a focus on innovative designs and analysis of clinical research for personalized medicine rare disorders and (dynamic) prediction.

Your working place will be at least 50% of time at the Medicines Evaluation Board (Utrecht, the Netherlands). At the Medicines Evaluation Board you will work in a team of clinical and methodology/statistical assessors consists of 10 statisticians. Your colleagues at the section Biostatistics are statisticians with various specializations, that work in close collaboration with many research departments throughout the Radboudumc. Biostatistics is part of the Department for Health Evidence, offering a multidisciplinary environment for methodological research in medicine.

Working at the Medicines Evaluation Board
The Medicines Evaluation Board is the regulatory authority for (approval of) medicines in the Netherlands, working in close collaboration with the European Medicines Agency. The Medicines Evaluation Board Agency provides scientific advice to companies on their development plans and assesses their applications for market authorization of medicines. The agency has more than 350 employees and is based in Utrecht.

Research Institutes
At the moment there are more than 1,300 PhD candidates at our medical hospital. This number includes PhD candidates on our pay roll as well as external candidates (those employed somewhere else but researching on our premises).

  • Radboud Institute for Health Sciences: ± 700
  • Radboud Institute for Molecular Life Sciences: ± 400
  • Donders Center for Medical Neurosciences: ± 200
Read what it is like to do a PhD at the Radboud University Medical Center.

Radboudumc
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc


Profile

You hold a MSc in (bio)statistics or related field. You have had training in more advanced quantitative analyses, preferably applied to medical, clinical or biological problems. You also have a proven scientific interest in medical or pharmacological applications. Futhermore you have the personal... read more

Profile

You hold a MSc in (bio)statistics or related field. You have had training in more advanced quantitative analyses, preferably applied to medical, clinical or biological problems. You also have a proven scientific interest in medical or pharmacological applications. Futhermore you have the personal skills to work in multidisciplinary and international teams.
 

Let's meet


Terms of employment

Within a 5 year period, 50% of your time is for research to achieve your PhD and 50% for training and working in scientific advice and regulatory assessment for marketing approval of drugs at the Medicine Evaluation Board (agentschap College Beoordeling Geneesmiddelen). read more

Terms of employment

Within a 5 year period, 50% of your time is for research to achieve your PhD and 50% for training and working in scientific advice and regulatory assessment for marketing approval of drugs at the Medicine Evaluation Board (agentschap College Beoordeling Geneesmiddelen).

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.

  • A gross monthly salary between € 2.631 and € 3.336 (scale 10A) based on full-time employment. In case of more extensive relevant experience, this could be adapted.
  • An annual vacation allowance of 8% and an end-of-year bonus of 8.3%.
  • If you work irregular hours, you will receive an allowance.
  • As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
  • Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
  • You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
 
In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the Cao UMC.


Application procedure

Will you make a difference for our patients? We would like to receive your application before 25 October 2022. We will then contact you shortly. read more

Application procedure

Will you make a difference for our patients? We would like to receive your application before 25 October 2022. We will then contact you shortly.

What else can you expect?

When you begin employment, we will request a certificate of conduct (VOG) and, depending on the position, you may be screened. You do not need to do anything for this; we will inform you later. 
 
Radboud university medical center is an employer that welcomes everyone. Every colleague brings valuable experience, expertise, and creativity. We believe in the benefits of a diverse and inclusive organization. #weareradboudumc

Read more about our application procedure or take a look at the frequently asked questions
 
We are recruiting for this vacancy ourselves. We only accept applications directly from the applicants themselves, but intermediaries are welcome to share our vacancies in their networks.​


Contact

Any questions? Please contact dr. Mark van Bussel, CBG-Medicines Evaluation Board, dr. Steven Teerenstra, Department for Health Evidence, or the promotor Prof.dr. Kit Roes, Department for Health Evidence. Use the Apply button to submit your application.
read more

Contact

Any questions? Please contact dr. Mark van Bussel, CBG-Medicines Evaluation Board, dr. Steven Teerenstra, Department for Health Evidence, or the promotor Prof.dr. Kit Roes, Department for Health Evidence. Use the Apply button to submit your application.

Find the job that suits you


All vacancies

View other interesting positions to vacancies

Job alert vacancies

Don’t want to miss a job opening? Get our latest vacancies sent right to your inbox! make job alert

Also interesting