• 36 hours a week
  • Temporary
  • 4 years
  • Date of publication: 3 May 2018
  • Deadline: 28 June 2018
  • Scale 10A: max € 40814 gross per year at full employment (incl. vacation bonus and end of year payments)
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Job description

We are looking for a highly motivated scientist to work on the epigenetics of impulsive and aggressive behaviour relevant to neurodevelopmental disorders, attention-deficit/hyperactivity disorder (ADHD) in particular. You will join our interdisciplinary research group at the Donders Institute for Brain, Cognition and Behaviour and will also spend 1 year (year 2 of the project) at the Brain Mind Institute of the École Polytechnique Fédérale de Lausanne (EPFL).
 
Both genetic factors and environmental adversity contribute to impulsivity and aggression, but research has mainly dealt separately with each of the two risk factor domains. Epigenetics research offers an excellent opportunity to integrate the contributions to behavior from a person’s genome and its environment. However, tissue- and cell-specificity of epigenetic profiles have largely held back epigenetics research in humans, where one has to work mainly with blood or saliva. In this project, we will combine the strengths of working with animal models involving dysfunctional attention, impulsivity, and aggression and studying existing, well-phenotyped longitudinal and cross-sectional ADHD cohorts at high risk for impulsivity and aggression.

This interdisciplinary, cross-species study will use innovative approaches to investigate the biological underpinnings of impulsivity and aggression in its genetic, epigenetic, and neural substrates. It will generate new insights into the role of gene-environment interplay in behaviours of high societal relevance. For this study, we can rely on extensive, high quality infrastructure and existing data sets. In addition, new data are also collected. The project will be supervised by Dr. Marieke Klein, Prof. Dr. Barbara Franke and Prof. Dr. Carmen Sand.

Profile

  • A highly motivated scientist with a Master’s degree in cognitive neuroscience or an adjacent field (psychological, biological, or biomedical) with affinity with psychiatry/psychiatric disorders;
  • A strong background in statistical analysis;
  • The ability to participate in an interdisciplinary research environment with a goal-directed attitude and good organizational skills;
  • Experience with linux environment, R coding, shell scripting, and/or other (bio)infomatics tools is a major plus;
  • Good communication and social skills, and willing to guide junior researchers and enjoys working as part of a team;
  • Interested in working in an international environment, with the opportunity to spend the second year of the project at the EPFL in Lausanne;

Organization

Radboudumc aims to be at the forefront of the development of innovative, sustainable and affordable healthcare. Our mission is 'to have a significant impact on healthcare'. We believe we can achieve that by providing excellent quality, participatory and personalized healthcare, operational excellence, and by working together in sustainable networks. To realize our mission, patient care, research, and education go hand in hand at Radboudumc.

The neuroscience research of Radboudumc is part of the Donders Institute for Brain, Cognition and Behaviour in Nijmegen in the Netherlands. The Donders Institute, with over 600 scientists, is a world-class research centre devoted to understanding the mechanistic underpinnings of human cognition and behaviour in health and disease.

The position will be placed at the Department of Human Genetics of the Radboudumc (in the PI-group of Prof. Barbara Franke), where you have the opportunity to collaborate and interact with renowned experts in the fields of genetics, bioinformatics, and neuroscience. At the EPFL, you will work at the Brain Mind Institute, working in the group of Prof. Carmen Sandi.

Radboudumc
Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. To get a better picture of what this entails, check out our strategy.

Read more about what it means to work at Radboudumc and how you can do your part.

Comments and contact information

The position is funded for 48 months, starting in summer 2018.

Application
Your application should consist of an up-to-date CV (including publications) as well as a personal motivation letter and contact information on two referees. Incomplete applications will not be considered.

Information
All additional information about the vacancy can be obtained from Prof. Dr. Barbara Franke, full professor Department of Human Genetics. Use the Apply button to submit your application.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be a screening based on the provided CV. Radboud university medical center’s HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Please apply before June 28, 2018.
Recruitment agencies are asked not to respond to this job posting.

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