Vacancies 59421-Bioinformatician-Bullseye-Project-Paul-Speth

  • 32 hours a week
  • Temporary
  • 3 years
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Job description

Within the Department of Medical Oncology, we are looking for a highly motivated bioinformatician with demonstrated interest in performing translational cancer research that impacts patients’ life. This research will primarily be performed on patients with metastatic melanoma, gynaecological and urogenital cancers, salivary duct carcinoma and sarcoma.
The department is looking for a bioinformatics postdoc or a highly motivated PhD candidate for a Paul Speth funded research entitled “Bullseye project: optimizing personalized cancer by implementation of cell-free tumour DNA sequencing”. The molecular landscape provides clinicians nowadays with a plethora of putative druggable targets; at present there is an unmet medical need for rapid, robust and non-invasive detection of clinical relevant aberrations in circulating tumour DNA (ctDNA) to optimize personalized medicine.
Tasks and responsibilities
  • Develop and implement bioinformatic analyses tools for ctDNA diagnostics (including single nucleotide variation, copy number aberration, and molecular signature detection; 
  • Implement bioinformatic analyses pipelines for whole-genome sequencing, within the context of an interdepartmental framework of bioinformatic teams from Genome Bioinformatics, Center for Molecular and Biomolecular Informatics (CMBI), Radboud Technology Center Bioinformatics, and TIL.

Preferably you apply as a (junior) postdoc. If you apply as a PhD candidate this data may form the basis of a PhD thesis.


Preferably, you have a PhD in bioinformatics/genomics/computational biology or related subject and have experience in performing bioinformatics research. If you are an enthusiastic and talented PhD candidate you should also apply!

You are ambitious, goal-oriented and a team-player, with experience in programming (java/python), linux, command line scripting, and statistical methods (R), and you’re familiar with commonly used tools for genomic data analyses. You are interested and experienced in writing scientific publications and are motivated to develop your own research topics. And:
  • Strong interest in translational cancer research;
  • Motivation, initiative and ambition to publish in high-impact journals;
  • Able to work both independently and interdisciplinary;
  • Excellent communication skills, contributing to a pleasant working atmosphere;
  • High level of proficiency in English.


The Department of Medical Oncology is part of the Radboudumc Center for Oncology. We place emphasis on working in multidisciplinary teams to improve both patient care as well as research. The nursing department, day care and outpatient clinic are all integrated to guarantee a well streamlined process in the treatment for our patients. There is extra attention for adolescence and young adults (AYA) with cancer, but also for the elderly cancer patients.
Embedded in our academic patient care are early stage clinical (medicinal) trials, and translational research; there is a close relation with the Tumour Immunology Laboratory (TIL), pathology and genetic departments. An important goal of this interdisciplinary teamwork is the translation of basic research into clinical application.
At this moment there are 14 staff members working within the Medical Oncology department (partly part-time connected to our department). There is a team of enthusiastic and involved clinical fellows, PhD students, medical researchers and students that contribute to an outstanding educational and scientific climate.
The Radboudumc aims to excel in all academic tasks and in giving the patient an important voice in the treatment team. To act together within networks and partnerships are topical issues of the Radboudumc subjects for giving shape to an optimal organization of sustainable oncology care.
The unique and individual patient is always the center of care at the Radboudumc.  Unique characteristics include the genetic background and individual tumour biology. The Department of Medical Oncology aims to personalize anti-cancer treatment for its patients with cancer; we are striving to improve patient stratification for targeted therapy and immunotherapy by matching optimal treatment based on next-generation sequencing results within the framework of multidisciplinary molecular tumour boards (MTB). We are also attempting to further optimize early response assessment and to improve early detection of disease recurrence, in a non-invasive manner in cell-free circulating tumour DNA, utilizing serial blood tests.

Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

Read more about what it means to work at Radboudumc and how you can do your part.

Employment conditions

Salary is depending on experience and the position.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be a screening based on the provided CV. Radboud university medical center’s HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Comments and contact information

All additional information about the vacancy can be obtained from drs. Erik Lambeck or from dr. Niven Mehra, medical oncologist. Use the Apply button to submit your application.

The vacancy is open until filled.
Recruitment agencies are asked not to respond to this job posting.

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