Vacancies 63702-PhD-candidate-Personalized-treatment-of-thyroid-diseases

  • 36 hours a week
  • Temporary
  • 4 years
  • Date of publication: 20 December 2018
  • Deadline: 1 February 2019
  • Scale 10A: max € 42220 gross per year at full employment (incl. vacation bonus and end of year payments)
  • First interview scheduled: 4 February 2019
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Job description

With a prevalence of 5-10%, thyroid diseases are among the most common diseases in the general population. Thyroid dysfunction, even mild, increases the risk of various adverse clinical outcomes, including myocardial infarction, atrial fibrillation, stroke, depression and mortality. The current goal of treatment is normalization of the patient’s serum thyroid parameters to levels within the population-based reference ranges. Despite having corrected thyroid hormone levels, ~15% of treated thyroid disease patients still have residual disabling hypo- or hyperthyroid complaints. Additionally, variation in thyroid function within the reference ranges is associated with cardiovascular disease and mortality. These are among the most important unresolved problems in endocrinology. All of this could be due to the fact that the thyroid parameters of the treated patient still deviate from their unique individual setpoint. Unfortunately, it is currently not possible to predict a patient’s individual thyroid setpoint. However, we have recently identified many individual characteristics and (epi)genetic markers which are associated with serum thyroid parameters. The aim of this PhD project is therefore to start individualizing the treatment of patients with thyroid diseases. 

Profile

  • A master’s degree in medicine or biomedical sciences;
  • Strong affinity with statistics and preferably working with large datasets;
  • Interest in translational research including various omics approaches (e.g., genomics, metabolomics);
  • Strong leadership and organizational skills to effectively coordinate projects in a large consortium;
  • Sufficiency in the Dutch language, fluency in written and spoken English.

Organization

The PhD candidate will be positioned at the department of Endocrinology. All projects will be embedded within the ThyroidOmics consortium, an international consortium which aims to personalize the treatment of thyroid diseases by using various omics approaches (e.g., genomics and metabolomics). This offers an exciting network with many international collaborators, providing a stimulating atmosphere for high quality research.

Radboudumc
Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

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Employment conditions

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Comments and contact information

The following should be included in your application: CV (including email address), list of followed courses (and grades if applicable), a letter of motivation, and reprints or, preferably, links to your Master thesis and scientific publications.

All additional information about the vacancy can be obtained from Dr. Marco Medici, internist-endocrinologist. Use the Apply button to submit your application.

Please apply before 1 February.
Recruitment agencies are asked not to respond to this job posting.

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