Vacancies 64502-Postdoc-Closed-loop-pacing-of-the-respiratory-muscles

  • 32 hours a week
  • Temporary
  • 11 months
  • Date of publication: 3 January 2019
  • Deadline: 1 February 2019
  • Scale 10.6: max € 49950 gross per year at full employment (incl. vacation bonus and end of year payments)
  • First interview scheduled: 6 februari 2019
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Job description

In the neurally controlled diaphragm pacing project, we aim to develop novel closed-loop diaphragm pacemaker technology that is controlled by the patient’s neural respiratory demands. Respiratory muscle weakness is a cardinal feature in many neuromuscular disorders, leading to suffocation or necessitating life-long mechanical ventilation. In spite its importance, therapies for diaphragm weakness are limited. Pacing of the respiratory muscles  is available, however, currently available diaphragm pacemaker technology is rudimentary and only applicable in limited patients. To overcome these limitations, a closed-loop approach is required that interacts with the patient’s individual physiological needs.
The scientific goal of this project is to provide a proof of principle of neurally controlled diaphragm pacing by obtaining pilot data from animal experiments. You will employ your activities at both the University of Twente and Radboud university medical center.

Tasks and responsibilities
  • You will be responsible for developing a control algorithm to detect the respiratory cycle from EMG of the respiratory muscles and stimulate the diaphragm, develop an experimental setup and perform experiments in animals;
  • You will use advanced signal processing techniques and functional electrical stimulation to reach this goal. Furthermore, you’re encouraged to be involved in writing a grant proposal to continue this project;
  • You are expected to perform research of high quality and be the link between institutions. It is expected to report on your research in international scientific journals.


  • A PhD degree in a related topic;
  • Expertise in neuromotor control research, e.g. measuring muscle activation (EMG) and/or neuromuscular electrical stimulation;
  • Expertise in signal processing, programming and statistical analysis and an innate ability for solution-oriented problem solving;
  • Preferably you have experience with respiratory research;
  • Preferably you have experience with animal experiments;
  • Expertise in working in multidisciplinary teams;
  • Team player with great communication skills;
  • Fluent in English, spoken and written;
  • Experience with writing grant proposals;
  • You enjoy working in a team, but can also handle a high degree of professional autonomy.


The Postdoc candidate will be appointed at the department of Neurology in the clinical neurophysiology research group as part of a multidisciplinary team of researchers in- and outside Nijmegen consisting of physicians, technical physicians and engineers. The position is funded by a recently awarded grant from the collaborative Twente University RadBoudumc Opportunities (TURBO) programme for a project called ‘Neurally controlled diaphragm pacing: a novel closed-loop approach to restore breathing in patients with respiratory muscle weakness. You will employ your activities at both the Radboud university medical center and University of Twente. At the University of Twente you will be part of the department Biomedical Signals and Systems (BSS).

Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

Read more about what it means to work at Radboudumc and how you can do your part.

Employment conditions

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Comments and contact information

All additional information about the vacancy can be obtained from Dr. Jonne Doorduin, assistant Professor Respitory Neurophysiology. Use the Apply button to submit your application.

Please apply before 1 February.
Recruitment agencies are asked not to respond to this job posting.

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