Vacancies 67044-PhD-candidate-Hereditary-cancer-spectrum

  • 36 hours a week
  • Temporary
  • 3 years
  • Date of publication: 4 April 2019
  • Deadline: 25 April 2019
  • Scale 10A/10: max € 60864 gross per year at full employment (incl. vacation bonus and end of year payments)
apply to job

Job description

The two most frequent hereditary cancer syndromes are Lynch syndrome (hereditary colorectal cancer caused by a germline mutation in a DNA mismatch repair gene) and hereditary breast and ovarian cancer caused by germline BRCA1/2 mutations. Tumor types that frequently arise due to these germline defects show molecular features known as microsatellite instability and genomic scarring (BRCAness), respectively. In light of putative novel therapeutic options based on these tumor genetic features, we aim to assess to what extend tumors for which the association with the germline defect is less clear also show microsatellite instability or BRCAness.
 
During this 3-year PhD-project you will investigate the tumor tissues from patients that are known to have a Lynch syndrome mutation or a germline BRCA1/2 mutation to unravel whether tumor types, which are not known to be in the spectrum of these predisposition syndromes, show the characteristic molecular features associated with the respective syndromes.
 
Tasks and responsibilities
  • Select and collect tumor samples from the national Pathology archive (PALGA);
  • Analyze tumors for specific molecular features using immunohistochemistry and next generation sequencing based molecular techniques;
  • Bioinformatics and statistical analyses;
  • Write scientific manuscripts;
  • Design and perform scientific research in the area of cancer genomics;
  • Present findings at local and (inter)national scientific meetings;
  • Work in a multidisciplinary team with other students and scientists to discuss, plan and perform research;
  • Finish the project with a scientific dissertation.

Profile

Candidates must have completed a Masters degree in Molecular Biology/Genetics, Medical Biology or equivalent. We are looking for an enthusiastic candidate with a strong interest in oncology. Experience with next-generation sequencing technologies, bioinformatics and statistical analysis is an advantage. Candidates should have good social and strong communication skills (fluent in English), a critical scientific attitude and the ability to work both independently as well as in an interdisciplinary team.

Organization

The department of Human Genetics has  more than 300 staff in outpatient clinics and laboratories for genome research and genome diagnostics. In the field of cancer genomics the department closely collaborates with the department of Pathology in the Laboratory of Tumor Genetics. This guarantees collaboration with specialists that work with state of the art genetic techniques and access to pathological expertise. The research is embedded in the Radboud Institute for Molecular Life Sciences.

Radboudumc
Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

Read more about what it means to work at Radboudumc and how you can do your part.

Employment conditions

The salary will be in scale 10 or scale 10A Cao umc depending on education. Scale 10A: max € 42220 gross per year at full employment (incl. vacation bonus and end of year payments) or scale 10: max € 60864 gross per year at full employment (incl. vacation bonus and end of year payments). 

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Comments and contact information

All additional information about the vacancy can be obtained from Prof. Nicoline Hoogerbrugge or Prof. Marjolijn Ligtenberg. Use the Apply button to submit your application.

Please apply before 25 April.
Recruitment agencies are asked not to respond to this job posting.

apply to job

more information


Working at Radboud university medical center

  • Read more about Terms & Conditions of employment.

    read more