Vacancies 67862-PhD-candidates-Department-of-Radiation-Oncology

  • 36 hours a week
  • Temporary
  • 4 years
  • Date of publication: 29 April 2019
  • Deadline: 10 June 2019
  • Scale 10A: max € 42220 gross per year at full employment (incl. vacation bonus and end of year payments)
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Job description

PhD 'Metabolism modulation with immunotherapy and radiotherapy' (project 1)
Tumor hypoxia has a negative impact on treatment outcome via direct radioresistance of hypoxic cells and poor perfusion of hypoxic areas. In addition, hypoxia provides a niche for clonogenic tumor stem cells and induces and sustains immunosuppression. Aim of this project is to improve the efficacy of the combination of high dose stereotactic radiotherapy and immune modulation by reducing tumor hypoxia and metabolic engeneering. Syngenic tumor models will be fully mapped using immunohistochemistry with semi-automated image analysis, FACS analysis and tumor monitoring by means of PET/SPECT imaging.
 
PhD 'Understanding cGAS activation to improve Immuno-radiotherapy combinations' (project 2)

The cGAS/Sting pathway links radiotherapy to immune activation. Potent immune response induction, however, requires immunogenic cell death and triggering of multiple immune activation pathways simultaneously. Aim of this project is to understand cGAS activation, to define immune pathways synergizing with cGAS and to define tumor ablative regimens optimal for Immuno-radiotherapy combinations. Immunological/Cell-biological approaches (FACS/functional assays, Transfection/Crispr/CAS, Microscopy) will be combined with syngeneic tumor models and state of the art tumor ablation technologies.

For the ROI laboratory we are also looking for an Postdoc position. See for more information our vacancy on the website. Upon malignant transformation, tumor cells upregulate the synthesis of sialic acid sugar-carrying glycans (sialoglycans). These sialic acids not only promote tumor cell growth but also protect them from recognition and eradication by immune cells. In this project novel human Siglec blocking mAbs will be tested in functional immunological assays and IHC in healthy donors and cancer patients.

Profile

The preferred candidates will have a MsC degree in biomedical sciences (molecular/cellular biology/medical biology/Immunology) or MD and a proven interest in pre-clinical research and a passion for science.

Candidates holding an article 9 certificate for working with experimental animals (project 1 & 2) and with a background in Microscopy & Molecular imaging (project 1) or functional Immunology /cell-biology (project 2) are especially invited to apply.

Organization

RIMLS and RIHS
The Radboud Institute for Molecular Life Sciences (RIMLS)  and the RadboudInstitute of Health Sciences (RIHS) in the Netherlands are leading European research schools providing an outstanding research and educational setting at the RadboudUMC. Together the RIMLS and RIHS focus on basic science and its translation into pioneering treatments for disease to the clinic.

Radiotherapy & OncoImmunology lab (Dept. of Radiation Oncology)
In the newly established ROI lab, ~ 25 researchers aim at better understanding tumor cell interactions with the immune system using imaging, molecular-, cell biological- and immunological- techniques in relation to cancer therapies, especially radiotherapy. Research is centred around the development of in situ cancer vaccines combining local tumor ablation and dendritic cell (DC) activation through immune adjuvants. In addition, the interplay between immune- and tumor cells is studied within the tumor microenvironment (TME) and modulation of the TME on the efficacy of treatment. An important activity of the department is the translation of basic research into clinical application.

Radboudumc
Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

Read more about what it means to work at Radboudumc and how you can do your part.

Employment conditions

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Comments and contact information

All additional information about the vacancy can be obtained from Prof. dr. G.J. Adema via +31 (24)361 45 15 or from Prof. dr. J. Bussink via +31 (24) 361 45 15. Use the Apply button to submit your application.

Please apply before 10 June.
Recruitment agencies are asked not to respond to this job posting.

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