- 36 hours a week
- 4 years
- Date of publication: 28 May 2019
- Deadline: 22 July 2019
- Scale 10A: max € 42220 gross per year at full employment (incl. vacation bonus and end of year payments)
- First interview scheduled: in week 32 2019
Job descriptionThis unique PhD project is situated at the crossroad of immunology, renal disease and nanomedicine development. Join our ambitious team!
The innate immune system plays a pivotal role in kidney diseases, including acute kidney injury due to ischemia reperfusion injury, autoimmune diseases causing glomerulonephritis, and rejection of transplanted kidneys. Recent studies in our center have discovered that innate immune cells can build a non-specific memory by epigenetic remodeling, resulting in an enhanced immune activity.
In this PhD project we focus on the mechanism and role of non-specific innate immune memory (“trained immunity”) in the context of renal disease and transplantation, as well as the development of innovative nanoimmunotherapies targeted at trained immunity. By specifically targeting innate immune cells with nanomedicine, we can regulate their behavior and thereby treat processes that drive renal diseases.
This research has a strong translational focus and will be conducted in vitro in cells and kidney organoids as well as in vivo in animal models and patients. This will be fostered by the implementation of advanced bioengineering, immunology and imaging techniques.
Tasks and responsibilities
- Plan, perform, analyze, and discuss scientific experiments;
- Contribute to scientific publications and present findings at scientific meetings;
- Works in a team with other students and scientists in a stimulating environment;
- Complete your project with a scientific dissertation.
ProfileWe are looking for an ambitious PhD candidate with initiative, motivation and social skills. You should have:
- Master degree in Molecular Life Sciences, Molecular Biology, Biochemistry, or similar;
- Excellent communication skills in English;
- Experience in cell culture, molecular and cell biological techniques;
- Experience with animal research would be a pre;
- Strong interest in immunology and renal disease.
OrganizationThe Department of Nephrology conducts fundamental and clinical research into kidney disease and renal replacement therapies. Fundamental research is aimed at unraveling the molecular and immunological mechanisms underlying glomerular disease, acute kidney injury and transplant rejection, and is located in the Nephrology Research Laboratory, part of the Radboudumc Institute for Molecular Life Science (RIMLS), a leading research institute within the domain of molecular mechanisms of disease.
Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.
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Employment conditionsUpon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.
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Comments and contact informationAssessment will be part of the selection procedure and will be performed by third party.
Applicants should send a letter of intent outlining special interest in the position, overall related qualifications, experience and career goals, a curriculum vitae and names and addresses of at least two professional references.
All additional information about the vacancy can be obtained from Raphaël Duivenvoorden, MD PhD via +31 (0)24 361 47 61 or from Johan van der Vlag, PhD via +31 (0)24 361 65 39. Use the Apply button to submit your application.
Please apply before July 22, 2019.
Recruitment agencies are asked not to respond to this job posting.
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