- 36 hours a week
- 3 years with an evaluation after 1 year
- Date of publication: 28 June 2019
- Deadline: 19 July 2019
- Scale 10: max € 60864 gross per year at full employment (incl. vacation bonus and end of year payments)
Job descriptionIn this project we will combine immunological (antigen presentation, tumor cytotoxicity assays, flow cytometry) with cell biological techniques (live cell imaging, signal transduction). An extensive immunological/cell biological background is therefore important.
Background of the project
Tetraspanin CD37: novel target for lymphoma
Tetraspanins belong to the transmembrane-4-superfamily that consists of small (20-50 kDa) transmembrane proteins that are abundantly expressed at the cell surface. We discovered that the B cell-specific tetraspanin CD37 is a novel tumor suppressor in lymphoma [de Winde et al. J. Clin.Invest. 2016, Xu-Monette et al. Blood 2016]. Targeting CD37 is currently under clinical investigation in patients with aggressive lymphomas [de Winde et al. Trends in Cancer 2017]. In this project, we will study novel CD37 antibodies (‘’hexabodies’’) in their cytotoxic capacity in human lymphomas. Secondly, we aim to identify the underlying molecular mechanism by investigating downstream signaling and CD37 organization at the cell surface of lymphomas using advanced microscopy techniques. This project is supported through the ERC (Consolidator Grant) and in collaboration with Genmab.
ProfileCandidates should have obtained a PhD degree in biology/immunology or equivalent.
OrganizationThe department of Tumor Immunology is a leading European department in basic- and translational- immunology. It host scientists from over 10 different nationalities and disciplines (Immunology, Molecular Biology, Chemical Immunology, Nanomedicine, Computational Immunology, and Medical Oncology)
The department is embedded in the Radboud Institute for Molecular Life Sciences (RIMLS) in the Netherlands, a leading European research school providing an outstanding research setting for the Radboud University. The RIMLS hosts excellent technology platforms such as genomics, proteomics, and molecular imaging.
Research within the department of Tumor Immunology aims at a better understanding of our immune system using molecular, cell biological, immunological, and computational techniques and is centered around antigen presenting dendritic cells which play an important role in regulating the immune response. An important activity of the department is the translation of basic research into clinical applications. In particular, we are developing novel dendritic cell based vaccines by using a chemical toolbox to treat cancer patients.
Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.
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Employment conditionsThe position is available for a period of 3 years. After a positive evaluation at 12 months, the contract will be extended.
Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.
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Comments and contact informationAll additional information about the vacancy can be obtained from Prof. Annemiek van Spriel, +31 (0) 24 361 76 00. Or take a look at the website. Use the Apply button to submit your application.
Please apply before July 19, 2019.
Recruitment agencies are asked not to respond to this job posting.
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