- 36 hours a week
- 3 years
- Date of publication: 25 November 2019
- Deadline: 30 December 2019
- Scale 11: min € 3808 - max € 5226 gross per month at full employment (excl. vacation bonus and end of year payments)
Job descriptionWe are looking for a senior post-doc to further (co-)develop our MR imaging and spectroscopy research line in oncology, with current emphasis on prostate cancer.
Screening, diagnosis, staging, surveillance and treatment monitoring of prostate cancer has top priority in our group. We are one of the few groups at the frontline of the introduction of multi-parametric (mp)MRI for the detection and staging of prostate cancer. Now that mpMRI of localized disease is mainstay, we are aiming at accurate and early staging of oligometastatic disease and treatment monitoring. Understanding pathophysiology of the disease is important, and quantitative mpMRI and (X-nuclear) spectroscopic imaging methods up to a field strength of 7T need to be developed and implemented to identify new (MR) biomarkers of disease progression.
Next to this, we aim at improved and earlier detection of lymph node metastases of prostate cancer, with the aid of a USPIO contrast agent for MRI and with 18F or 68Ga-PSMA PET-CT. Finding small lymph node metastases is a major challenge, which we tackle with the latest MRI-technology at ultra-high magnetic field (7T) and this USPIO nanoparticle contrast agent.
Together with our research team in Essen, Germany (Professor Harald Quick) we will develop and implement new 7T MR hard- and software needed to perform iron-sensitive MRI of the pelvis, together with acquiring metabolic information of the prostate.
By optimizing the sensitivity for iron, using dedicated MRI pulse sequences, we intend to push the boundaries to detect the smallest – potentially sub millimetre – metastatic lymph nodes. Next to lymph node staging, we will improve anatomical, functional and metabolic imaging of the primary tumor at 7T to better assess primary cancer stage. Our final aim is to enable 7T MRI-guided targeted therapy, thereby allowing personalized treatment of prostate cancer (and other cancer types).
Tasks and responsibilities
- MR pulse sequence development and implementation on Siemens 3 and 7T MRI systems.
- Patient examinations at 3 and 7T.
- Writing scientific publications and grant proposals.
- Co-supervise PhD students.
The development and application of novel MR methods for the diagnosis, disease prediction and treatment monitoring of human cancers is a main research focus at our department Radiology and Nuclear Medicine. We are one of the leading groups in MR of (prostate) cancer, with many years of experience in this field ((Associate) Professors Tom Scheenen, Jurgen Fütterer, Arend Heerschap, Jelle Barentsz). This research is integrated with clinical examinations and other investigations of cancer cells or tissues to find the best solution for (bio-) medical questions. Our cancer research is translational: to support human studies with new perspectives and understanding, parallel MR investigations are performed in animal models. The group is composed of senior researchers, post-docs, PhD students and technical staff with clinical, biological, bio-chemical, bio-physical, engineering and technical backgrounds. We collaborate intensively with the departments of urology, pathology, radiotherapy, and internal medicine, and with many groups at national and international level (e.g. in EU and US).
We are looking to further expand the existing team with Dr. Ir. Tom Scheenen as Principle Investigator.
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Employment conditionsWe offer a fulltime job for a period of 3 years, with salary according to the collective agreement (CAO) of Dutch universities.
Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.
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Comments and contact informationRequested Info
- An application letter with your current research interests and research plans for the future.
- A cv including a complete list of publications, lectures at conferences and a list of third party funding. Highlight five key publications that you consider particularly relevant to this position, and describe your contributions to these publications.
- 2 Reference names or 2 letters of recommendations.
Please apply before 30 December.
Recruitment agencies are asked not to respond to this job posting.
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