- 36 hours a week
- 2 years
- Date of publication: 27 November 2019
- Deadline: 15 January 2020
Job descriptionBreaking the circle: interleukin-1β stimulation of adipose stem cells increases their therapeutic efficacy in posttraumatic osteoarthritis via potentiation of anti-inflammatory actions in neutrophils (RN 18-1-204).
We are looking for a research technician, junior researcher or a postdoc to investigate mechanisms involved in the interplay between adipose stem cells, the immune system and joint destruction in osteoarthritis (OA). Low-grade joint inflammation is present in more than 50% of OA patients and recently it was found that local application of adipose stem cells inhibits macrophage activation within the synovium, which suppresses development of joint destruction. The goal of this project, which is subsidized by the Dutch Arthritis Society, is to unravel mechanisms involved in the interplay between stem cells and synovial activation and the impact on joint pathology in osteoarthritis in order to develop novel therapeutic targets to combat this crippling disease.
ProfileYou hold a university degree (Technician, MSc, PhD or equivalent) in medical biology or biomedical sciences with an interest in immunology and pathology. Experience with handling DNA and RNA, histology, culturing techniques and animal work (article 9) is preferred. We offer an interesting temporary research position in a dynamic, multidisciplinary and international environment. The work will be performed in the Experimental Rheumatology lab in Nijmegen.
OrganizationThe research group of Experimental Rheumatology, part of the Department Rheumatology, in Nijmegen has gained a worldwide reputation in basic and clinical rheumatology research with a track record of >500 peer-reviewed scientific papers. The department takes part in the research program of the Radboud Institute for Molecular Life Sciences (RIMLS). The RIMLS trains students and PhD students and conducts research in medical research. In this project we aim to unravel mechanisms involved in stem cell driven protection of development of joint pathology in inflammatory osteoarthritis.
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Employment conditionsWe offer a fulltime job for a period of 2 years, with salary according to the collective agreement (CAO) of Dutch universities. A research technician will be offered scale 7 (maximum € 3.184) and the junior researcher and postdoc scale 10 (maximum 4.481) gross per month based on a full-time employment excluding holiday allowance and 8.3% year-end bonus.
Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.
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Comments and contact informationAll additional information about the vacancy can be obtained from Dr. Peter van Lent, associate Professor, +31(024) 361 05 12 or +31(024) 361 65 40. Use the Apply button to submit your application.
Please apply before 15 January.
Recruitment agencies are asked not to respond to this job posting.
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