Vacancies 77741-PhD-candidate-Gene-therapy-development-for-Usher-syndrome-type-2C
  • 36 hours a week
  • Bepaalde tijd
  • 4 years
  • Date of publication: 8 January 2020
  • Deadline: 29 January 2020
  • Scale 10A: min € 2422 - max € 3103 gross per month at full employment (excl. vacation bonus and end of year payments)
  • First interview scheduled: 13 February 2020
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Job description

Usher syndrome (USH) is a rare but severely debilitating condition that affects two major sensory organs in humans (hearing and vision). For patients with Usher syndrome, the combination of progressive vision loss and congenital hearing impairment has an enormous negative impact on the quality of life. This is for example illustrated by the severe limitations this disorder causes in terms of independence and social interactions.

Mutations in the ADGRV1 gene cause Usher syndrome type 2C (USH2C) in approximately 40,000 people worldwide. These patients progressively lose their eyesight, resulting in almost complete blindness in their fifth or sixth decade of life, leaving time for therapeutic intervention. The size of the ADGRV1-encoding sequence and the lack of an early retinal phenotype in the available Adgrv1 knockout mouse model, long hampered the development of a treatment for ADGRV1-associated retinal degeneration. 

This project aims to explore the potential of ADGRV1 minigene augmentation therapy to stop or slow down the progressive retinal degeneration in Usher syndrome type 2C using zebrafish as a model, with the ultimate goal to improve the patient’s quality of life.


  • Master’s degree in Biology, Molecular Life Sciences or Biomedical Science.
  • Hands on working experience in molecular biology and cell biology.
  • Experience and affinity with zebrafish handling (article 9 certified).
  • Enthusiastic team player.
  • Creative and out-of-the-box thinking.
  • Accurate.
  • Hands on mentality.
  • Analytical and flexible.
  • Excellent knowledge of the English language (spoken and written).
  • Ability to work under pressure.
  • Academic writing and presentation skills.


At the department of Otorhinolaryngology we are looking for a PhD candidate that will perform research at the crossroads of the departments of Otorhinolaryngology, Human Genetics and Ophthalmology within a multi-disciplinary project entitled “Pre-clinical development of a minigene augmentation therapy for the future treatment of USH2C-associated retinitis pigmentosa”. Furthermore, the PhD candidate will take part in the activities for graduate candidates of the Donders Institute for Brain, Cognition and Behaviour.

Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

Read more about what it means to work at Radboudumc and how you can do your part.

Employment conditions

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Comments and contact information

We offer a 4 year appointment in an exciting and innovative working environment within a very committed and international organization, great colleagues and a lot of fun!
Do you want to be part of our devoted team of enthusiastic professionals? Do you think you can contribute in achieving our mission? Do you want to work in a challenging environment where your work can really make a difference? If so, we’re looking forward to receive your application by sending us your written Curriculum Vitae accompanied by a letter of application. 

All additional information about the vacancy can be obtained from dr. Erwin van Wyk, Assistant Professor; head Usher Syndrome Therapeutics Research UnitUse the Apply button to submit your application.

Please apply before 29 January.
Recruitment agencies are asked not to respond to this job posting.

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