- 36 hours a week
- 4 years
- Date of publication: 30 January 2020
- Deadline: 20 February 2020
- Scale 10A: min € 2422 - max € 3103 gross per year at full employment (incl. vacation bonus and end of year payments)
- First interview scheduled: 12 March 2020
Job descriptionProject description
Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of all kidney cancers. These tumors are highly resistant to chemotherapy and radiotherapy, which is reflected by a poor 5-year survival rate of <10%. Therefore, new treatment options are urgently needed. In this KWF-funded project we will develop new radiolabeled agents which specifically bind to ccRCC cells and will be used for targeted radionuclide therapy. Tumor-targeting agents will be labelled with various radionuclides suitable for imaging (Zr-89) and therapy (Ac-225 and Lu-177). In vitro, we will assess their cell binding properties and therapeutic potential. Furthermore, in vivo studies will be carried out in tumour-bearing mice to assess the tumor-targeting properties, biodistribution, pharmacokinetics, therapeutic efficacy, and toxicity. Also, in order to translate this approach to a safe and individualized treatment, dosimetric models will be developed based on the Zr-89 PET images and ex vivo biodistribution data to perform treatment planning on the curative dose that can be safely administered in mice. Finally, these dosimetric models will be translated to the clinical setting making use of Zr-89 PET scans of ccRCC patients.
Tasks and responsibilities
The PhD candidate will:
- Design and perform scientific research with radiolabelled ccRCC-targeting agents (radiolabelling, in vitro cell binding experiments, animal experiments, pharmacokinetic modelling and dosimetry calculations).
- Analyse scientific data.
- Write scientific publications and present findings at (inter)national scientific meetings.
- Work in a team with other scientists and clinicians to plan, discuss, and perform research in a stimulating environment.
- Master’s degree in (Medical) Biology, Biomedical sciences, Molecular life sciences, or equivalent.
- Permit to work with laboratory animals (or willing to obtain this permit).
- Permit to work with radioactivity (or willing to obtain this permit).
- Well-developed communicational and social skills directed towards working in a team.
- Enthusiastic and strong motivation to successfully complete a PhD.
OrganizationThe Department of Radiology, Nuclear Medicine and Anatomy has a long-standing research line on the development and application of radiolabeled tracers for imaging and targeted radionuclide therapy. Within the department, there is a strong focus on translational research by collaborations between basic scientists and clinical researchers. The department has excellent research facilities, including level B radionuclide laboratories and a preclinical imaging center (PRIME) with state-of-the art imaging facilities including microPET/CT, microSPECT/CT, IVIS fluorescence/bioluminescence, and small-bore high-field MRI. The research group consists of approximately 25 researchers, including senior scientists, PhD students, medical doctors, and research technicians.
At the moment there are more than 1,300 PhD candidates at our medical hospital. This number includes PhD candidates on our pay roll as well as external candidates (those employed somewhere else but researching on our premises). Read what it is like to do a PhD at the Radboud University Medical Center.
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Working conditionsUpon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.
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Comments and contact informationAll additional information about the vacancy can be obtained from Dr. Sandra Heskamp, assistant professor Radiology and Nuclear Medicine. Use the Apply button to submit your application.
Please apply before 20 February 2020.
Recruitment agencies are asked not to respond to this job posting.
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