Vacancies 79081-PhD-candidate-Tumor-deposits-the-origin-of-distant-metastases
  • 36 hours a week
  • Temporary
  • 4 years
  • Date of publication: 10 February 2020
  • Deadline: 2 March 2020
  • Scale 10A: min € 2422 - max € 3103 gross per year at full employment (incl. vacation bonus and end of year payments)
  • First interview scheduled: week 11
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Job description

Do you want to make a difference for patients with colorectal cancer? Do you want to know what is actually causing metastatic disease? Then you should join our team! The Dutch Cancer Society (KWF) has awarded a project grant to our team at the Radboudumc to investigate the origin of metastases in colorectal cancer. For tumor cells to go from the primary tumor site towards distant organs, a number of possible methods of spread will be explored. Traditionally, lymph nodes were seen as the most obvious way to facilitate tumor spread, however, recent findings suggest other possible origins for metastases. Tumor deposits are associated with a high risk on metastases, as well as with a number of so-called metastatic highways, like blood and lymph vessels as well as nerves.

Using patient cohorts, in this 4-year PhD project we will seek the answers on the following questions: where do tumor deposits come from and where are they going (finding biological evidence)? How should we define tumor deposits and how do we put them in the right position for adequate staging (an international consensus approach)? And finally: can we determine the clinical implications of this phenomenon: what are the effects of treatment on patients with tumor deposits?

You will work in an international multidisciplinary team at the Radboudumc, with pathologists, surgeons and molecular biologists, in close collaboration with our partners from the radiology department of the Royal Marsden hospital in London (UK). This project is part of the Research Theme "Tumors of the Digestive Tract", one of the core themes of the Radboud university medical center. You will be part of a cross-disciplinary research team striving to do world-class science and answer many questions about hereditary cancer.


We are seeking a highly motivated candidate with (most of) the following qualifications:
  • Master's degree in Biomedical Sciences, (Medical) Biology, Medicine, or a relevant other discipline.
  • Interest in tumor genetics and pathogenesis.
  • Experience with molecular biological techniques.
  • Affinity with next generation sequencing technologies, microscopic evaluations and analysis of large data sets.
  • Structured and accurate working style, demanding high quality of your own work.
  • Good English writing and presentation skills.
  • Strong self-motivation, flexibility, and persistence.
  • Well-developed skills to work in a multidisciplinary team.


You will join a multidisciplinary team at the department of Pathology, supervised by Prof. dr. Iris Nagtegaal (Pathologist) and Dr. Femke Simmer (molecular biologist).  We will train and mentor you during the course of this project. You will join the PhD program of the Radboud Institute for Molecular Life Sciences (RIMLS).

Research Institutes
At the moment there are more than 1,300 PhD candidates at our medical hospital. This number includes PhD candidates on our pay roll as well as external candidates (those employed somewhere else but researching on our premises).
  • Radboud Institute for Health Sciences: ± 700
  • Radboud Institute for Molecular Life Sciences: ± 400
  • Donders Center for Medical Neurosciences: ± 200
Read what it is like to do a PhD at the Radboud University Medical Center.

Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

Read more about what it means to work at Radboudumc and how you can do your part.

Working conditions

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Comments and contact information

All additional information about the vacancy can be obtained from Prof. Dr. Iris Nagtegaal, Professor of Gastrointestinal Pathology. Use the Apply button to submit your application.

Please apply before 2 March 2020.
Recruitment agencies are asked not to respond to this job posting.

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