Vacancies 84001-Junior-researcher-PROSPAX-studie
  • 32 hours a week
  • Bepaalde tijd
  • 3 years
  • Date of publication: 17 June 2020
  • Deadline: 8 July 2020
  • Scale 10: min € 2826 - max € 4481 gross per month at full employment (excl. vacation bonus and end of year payments)
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Job description

We are looking for a junior researcher who is keen to work on a European project on a rare neurological disease. Spastic ataxias (SPAX) represent a rapidly growing group of >100 rare neurodegenerative genetic diseases with joined affection of the cerebellum and corticospinal tract. They often manifest early in life, with devastating chronically progressive consequences on daily life while treatment options are limited to symptom relief. Genetic advances now facilitate the development of targeted molecular therapies and pave the way towards a precision medicine approach of SPAX. However, effective trial-planning in SPAX diseases is hampered by several challenges.

First of all, SPAX patients and clinical data or biomarker collections are fragmented. Second, there is lack of SPAX-specific, longitudinally validated outcome measures and a complete lack of digital and patient-reported outcomes. To overcome these challenges, the EU/ZonMW-funded PROSPAX project will unite all major European ataxia centers in a multi-center prospective natural history study. The aim of this study is to longitudinally validate existing disease markers and develop novel clinical, digital, imaging and molecular outcome measures in a cohort of ARSACS and SPG7 patients. All centres contribute to the natural history study and to the collection of MRI data and biosamples for biomarker discovery. Together with the coordinating centre in Tübingen, Radboud university medical centre will also create and validate a mobile toolbox (app) of digital, smartphone and wristband sensor-based performance measures of daily living that will capture patient-centered outcomes of daily living with SPAX.

The junior researcher will work closely together with Dr. Bart van de Warrenburg and Dr. Jorik Nonnekes. You will also be embedded in the large research group of the Center of Expertise for Parkinson Movement Disorders

Tasks and responsibilities
As a junior researcher you will:
  • Plan, organize and perform the assessments in people with SPAX.
  • Analyse the data.
  • Help to present the results in scientific papers.
  • Closely interact with the Tübingen partner and the involved tech company.
  • Depending on the progress and additional funding, the contract may be extended into a PhD-trajectory.


  • Hold a Master’s Degree (preferably in in Technical Medicine, alternatives are Human Movement Science or Biomedical Sciences).
  • Be ambitious, well-organized, independent. Have a keen interest in neurological disorders and movement analysis.
  • Expertise in data analysis (e.g. using Matlab).
  • Expertise in clinical examination of patients.
  • Be proficient in both Dutch and English (in oral as well as written communication).
  • Have excellent communicative and social skills.


In Radboudumc's center of expertise for Parkinson and Movement Disorders, care, research and innovation is practiced around neurological movement discorders. Apart from Parkinson's disease, rare and inheritable movement disorders are important areas of interests in the Center. This expertise is acknowledged by the Dutch Ministry of Health, Welfare and Sports.

One type of these rare and inheritable movement disorders are diseases of the cerebellum (cerebellar ataxia). The center of expertise sees lots of patients with ataxia and has a great functioning translational research line towards these diseases.

Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

Read more about what it means to work at Radboudumc and what our people have to say about it.

Employment conditions

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, screening based on the provided cv. Radboud university medical center HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Comments and contact information

All additional information about the vacancy can be obtained from Dr. Jorik Nonnekes, physiatrist or Dr. Bart van de Warrenburg, neurologist. Use the Apply button to submit your application.

Please apply before 8 July 2020.
Recruitment agencies are asked not to respond to this job posting.

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