Vacancies 85621-Clinical-PhD-candidate-Next-gen-in-vivo-cancer-diagnostics
  • 36 hours a week
  • Temporary
  • 3 years
  • Date of publication: 28 July 2020
  • Deadline: 17 August 2020
  • Scale 10A/10
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Job description

To increase the survival and quality of life of (cancer) patients, it is important to make the correct diagnosis, and give optimal treatment while reducing the side effects of the treatment itself. Image-guided therapy and minimally invasive surgery is expected to play an increasing role to achieve this goal. It is important to have adequate imaging before and during treatment in this respect. One of the techniques that can be used for this is Optical Coherence Tomography (OCT). OCT is already widely used as a scanning technique in ophthalmology. The next step for OCT is that it will also be used in vivo. However, to obtain in-vivo OCT images, a catheter is required. To be able to use such a catheter in the clinic, aspects still need to be optimized or developed. These developments will take place in this research project.

In addition, the OCT catheter has so far only been investigated for the application area of diagnosis and treatment of bladder cancer, while the catheter can also be used for other indications. For example to check resection margins of removed tissue or to diagnose abnormalities in solid organs.

This EFRO funded project aims to research which other indications within these two domains are suitable for the use of the OCT catheter. With the use of decision analytical modeling it will be assessed for which indications the use of the OCT catheter has the highest potential value with regard to improving health outcomes and cost-effectiveness of treatment. Subsequently, a phase I trial will be conducted to investigate the feasibility of such a catheter for the selected indications. For this project we are seeking a PhD student who will perform both the decision analytical modeling and the phase I trial.


A creative and enthusiastic researcher with an excellent MSc degree in a relevant field, such as biomedical technology, technical medicine or medicine. The ambition and academic skills to write and present scientific papers as well as to perform data-analysis.


The Minimally Invasive Image-Guided Intervention Center (MAGIC) is a research group that has its roots in MRI-guided prostate treatment, and we have expanded to CT-, US-, and MR- image guided oncologic interventions; as for example biopsy of prostate, bone and liver; (non-) thermal ablations of pancreas, liver, kidney, prostate and vascular malformations. Supplementary we focus on nuclear interventions with Holmium particles; intra-operative navigation; robotics; ex-vivo imaging; clinical decision support; and perfusion and vascular interventions. The interventions are developed and performed in close collaboration with the Medical Innovation and Technology expert Center (MITeC). The MAGIC is a research division of the Department of Imaging of the Radboud University Medical Center Nijmegen.

The evidence-based surgery (EBS) research group belongs to a relatively new discipline that investigates the usefulness of surgical techniques, whether or not they are cost-effective and if so, for which groups of patients. An important area of research within the EBS group is early Health Technology Assessment (HTA). Early HTA comprises the early assessment of the potential value of innovative techniques and approaches to optimize the efficiency and effectiveness of surgical interventions. The EBS group works together with MAGIC within MITeC to develop interventions that increase health outcomes for the patient and are cost-effective. EBS is a research division of the department of operating rooms within the Radboudumc.

Research Institutes
At the moment there are more than 1,300 PhD candidates at our medical hospital. This number includes PhD candidates on our pay roll as well as external candidates (those employed somewhere else but researching on our premises).
  • Radboud Institute for Health Sciences: ± 700
  • Radboud Institute for Molecular Life Sciences: ± 400
  • Donders Center for Medical Neurosciences: ± 200

Read what it is like to do a PhD at the Radboud University Medical Center.

Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

Read more about what it means to work at Radboudumc and what our people have to say about it.

Employment conditions

The salary depends on education. Scale 10 will be offered to MSc medical graduates; those holding degrees in other disciplines will be offered scale 10A.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Comments and contact information

In your application include a motivation letter, your CV, list of grades and links to publications, your Master thesis or other works you have written in English.

All additional information about the vacancy can be obtained from Prof. Jurgen Fütterer, professor Radiology and Nuclear Medicine, (+31) 24 361 40 11. Use the Apply button to submit your application.

Please apply before 17 August 2020.
Recruitment agencies are asked not to respond to this job posting.

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