- 36 hours a week
- 9 months
- Date of publication: 30 July 2020
- Deadline: 27 August 2020
- Scale 8: min € 2769 - max € 3712 gross per month at full employment (excl. vacation bonus and end of year payments)
- First interview scheduled: 21 September 2020
Job descriptionSeveral important human viruses such as Dengue, Zika and Chikungunya virus rely on the transmission by mosquito vectors. This makes mosquitoes a prime target to develop intervention strategies to interfere with virus transmission and disease. In fact, the largescale distribution of insecticides is still a main strategy to fight vector-borne virus diseases. However, insecticides frequently lead to the development resistant mosquitoes, limiting their long-term effectiveness. Moreover, they can cause substantial collateral damage to beneficial, pollinating insects, harming natural ecosystems.
In this proof-of-principle study, we aim to investigate whether administering antiviral compounds to mosquitoes can be used to reduce virus replication in the vector, thereby preventing virus transmission. We will use Aedes aegypti, the most important tropical mosquito responsible for virus transmission as a model. Several hundred small molecule compounds will be screened for antiviral activity in mosquito cells and hits will be further tested in adult mosquitoes. These experiments will be performed in our dedicated high safety level mosquito laboratory. This project has been co-designed by the Experimental Virology group at the Radboudumc Nijmegen and the local biotech company TropIQ health science.
- BSc degree in Applied Laboratory Sciences (HLO) or equivalent. Students who hold a recent MSc degree in Molecular Life Sciences, Biomedical Sciences, or a related program are also invited to apply.
- Interest in Molecular virology.
- Experience in working at biosafety level 2 (or higher).
- Experience with high-throughput molecular assays is preferred.
- Experience in insect rearing and manipulation is preferred.
- Good communication skills and good command of spoken and written English.
OrganizationThe laboratory of Experimental Virology studies molecular aspects of arbovirus infection. Together with other groups of Radboud University Medical Center, the lab is based in the Radboud Institute for Molecular Life Sciences (RIMLS), a multidisciplinary research institute in the life sciences.
RIMLS provides a stimulating scientific environment, with state-of-the-art core facilities, including cellular imaging, proteomics, and genomics In 2018, an Aedes mosquito facility including biosafety level 3 laboratory was opened.TropIQ is societal partner of this project. The biotech company develops intervention strategies against mosquito-borne diseases and will contribute to this project by miniaturizing the cell-based assays and optimizing a high-throughput screen in adult mosquitoes.
Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.
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Employment conditionsUpon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.
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Comments and contact informationApplications
Applicants should write a motivation letter outlining specific interest in the position, a list of grades, a curriculum vitae, and contact information of professional references.
All additional information about the vacancy can be obtained from Dr. Pascal Miesen Use the Apply button to submit your application.
For more information, visit www.vanrijlab.org.
Please apply before 27 August 2020.
Recruitment agencies are asked not to respond to this job posting.
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