Vacancies 93981-PhD-candidate-Molecular-mechanisms-of-actin-isoform-usage-in-cancer-cell-migration

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About the vacancy

  • 36 hours per week
  • Temporary
  • 4 years
  • Scale 10A: min € 2495 - max € 3196 gross per month for full-time employment (excluding holiday pay and year-end bonus)
  • Deadline: 1 April 2021

Job description

Tumor metastasis involves the migration of cancer cells from the primary tumor site to distant organs and is the primary cause of cancer-related morbidity and mortality. The shape changes that allow cancers cells to migrate are critically controlled by the actin cytoskeleton. While the actin...

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Job description

Tumor metastasis involves the migration of cancer cells from the primary tumor site to distant organs and is the primary cause of cancer-related morbidity and mortality. The shape changes that allow cancers cells to migrate are critically controlled by the actin cytoskeleton. While the actin cytoskeleton comprises a wide variety of functionally distinct actin-based structures, the molecular basis of this diversity remains poorly understood. Recent studies by Dr. van den Dries and others have demonstrated that actin-based structures have distinct compositions of highly similar actin isoforms. We hypothesize that a better understanding of the biology of these isoforms will explain the functional diversity of actin-based structures.

In this project, we aim to define the fundamental molecular principles by which actin isoform usage controls the functional diversity of the actin cytoskeleton. For this, the candidate will use a combination of advanced genetic engineering, molecular biological techniques, (super-resolution) microscopy and machine learning approaches. We will use the novel insights into the regulation of the cytoskeleton to study cancer cell migration in diverse model systems both in vitro and in vivo.

Tasks and responsibilities

  • Plan, perform, analyze, and discuss experiments; set up new protocols and assays.
  • Attend work meetings as well as activities of the RIMLS PhD programme.
  • Possible supervision of bachelor/master students (from year 2 or 3 on).
  • Take responsibility for your own project and lead it to a successful PhD thesis.


Profile

We are looking for an ambitious PhD candidate with talent, initiative, motivation and endurance. Ideally, you also have a Growth Mindset ; a keenness to invest in the development of both yourself and the team. You should have: a MSc degree (or equivalent) in a relevant Life Science discipline...

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Profile

We are looking for an ambitious PhD candidate with talent, initiative, motivation and endurance. Ideally, you also have a Growth Mindset; a keenness to invest in the development of both yourself and the team. You should have:

  • a MSc degree (or equivalent) in a relevant Life Science discipline: (medical) biology, biomedical sciences, medicine, biochemistry, bioengineering.
  • Strong interest in cell biology and the fundamental molecular principles of biological processes.
  • Excellent communication skills in English. 


Terms of employment

For promovendi, the collective labour agreement (CAO) for university medical hospitals (umc) applies. The CAO-UMC document can be found here .

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Terms of employment

For promovendi, the collective labour agreement (CAO) for university medical hospitals (umc) applies. The CAO-UMC document can be found here.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.


Department

The candidate will join the PhD programme of the Radboud Institute for Molecular Life Sciences ( RIMLS ), where Dr. Koen van den Dries leads a start-up research group that is focused on unraveling the molecular mechanisms that control the functional diversity of the cellular cytoskeleton to...

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Department

The candidate will join the PhD programme of the Radboud Institute for Molecular Life Sciences (RIMLS), where Dr. Koen van den Dries leads a start-up research group that is focused on unraveling the molecular mechanisms that control the functional diversity of the cellular cytoskeleton to regulate key cell biological processes in health and disease.

To address these unresolved biological questions, the group of Dr. van den Dries integrates state-of-the-art imaging techniques, quantitative image analysis, advanced molecular tools and genetic engineering approaches. The group is embedded in the department of Cell Biology of the Radboudumc, Nijmegen, The Netherlands. The department of Cell Biology is closely associated with the Radboud Technology Center Microscopy, allowing easy access to advanced microscopy techniques.

Research Institutes
At the moment there are more than 1,300 PhD candidates at our medical hospital. This number includes PhD candidates on our pay roll as well as external candidates (those employed somewhere else but researching on our premises).

  • Radboud Institute for Health Sciences: ± 700
  • Radboud Institute for Molecular Life Sciences: ± 400
  • Donders Center for Medical Neurosciences: ± 200
Read what it is like to do a PhD at the Radboud University Medical Center.

Radboudumc
Radboudumc in Nijmegen strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

Read more about what it means to work at Radboudumc and what our people have to say about it.


Contact

All additional information about the vacancy can be obtained from Dr. Koen van den Dries , associate professor Cell Biology. Use the Apply button to submit your application.

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Contact

All additional information about the vacancy can be obtained from Dr. Koen van den Dries, associate professor Cell Biology. Use the Apply button to submit your application.

The first-round interviews are taking place on 12 until 16 April.  

Please apply before April 1.
Recruitment agencies are asked not to respond to this job posting.

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