Vacancies 97521-Postdoc-Splicing-modulation-therapy-for-Stargardt-disease

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About the position

  • 36 hours per week
  • Temporary
  • 2 years
  • Deadline: 11 May 2021
  • Date first interview: 17 - 21 May 2021

#weareradboudumc, what about you?


Job description

In this project, funded by the Foundation Fighting Blindness USA, it is our aim to further translate preclinical proof-of-concept of AONs for Stargardt disease to clinical application, by optimizing selected AON sequences and assess their efficacy and safety in retinal organoid models.

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Job description

In this project, funded by the Foundation Fighting Blindness USA, it is our aim to further translate preclinical proof-of-concept of AONs for Stargardt disease to clinical application, by optimizing selected AON sequences and assess their efficacy and safety in retinal organoid models.

As a postdoc you take a central role in the molecular and cellular work that is needed to prepare the most promising AONs for clinical studies.

Tasks and Responsibilities:

  • Plan and perform scientific experiments in an independent manner.
  • Critically analyze data.
  • Supervise junior scientists (technicians, MSc/BSc students) in the lab.
  • Take a leading role in writing manuscripts.
  • Present data at local, national and international scientific meetings.


Department

The “Molecular Therapy for Inherited Retinal Diseases” group, headed by Prof. dr. Rob Collin and his colleague Dr. Alex Garanto, aim to develop various therapeutic interventions for inherited retinal diseases, with a strong focus on splice modulation and RNA therapies.

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Department

The “Molecular Therapy for Inherited Retinal Diseases” group, headed by Prof. dr. Rob Collin and his colleague Dr. Alex Garanto, aim to develop various therapeutic interventions for inherited retinal diseases, with a strong focus on splice modulation and RNA therapies.

Stargardt disease is a progressive retinal disease that initially affects central vison, and later in life can lead to complete blindness. Stargardt disease can be caused by numerous different mutations in the ABCA4 gene, some of which cause pre-mRNA splicing defects in ABCA4. Over the last decade, our group has demonstrated pre-clinical proof-of-concept for splicing modulation therapy using antisense oligonucleotides (AONs) for several different subtypes of retinal disease, including Stargardt disease. In addition, the first application of AONs in the human eye have revealed encouraging results, with improved visual function upon ocular administration of AONs in patients with retinal disease. 

The research is embedded at the Department of Human Genetics within the Radboudumc in Nijmegen, which is internationally renowned for its research and diagnostics on a variety of genetic and genomic disorders. The Department offers an exciting work environment with enthusiastic people from many parts of the world enjoying high quality research.

Radboudumc
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc


Profile

You have obtained your PhD degree in the last three years (or submitted your thesis to the manuscript committee), in the field of molecular and/or cellular biology. You have a strong experimental background in molecular (genetic) research, including studies with DNA, RNA and/or protein (e.g. PCR,...

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Profile

You have obtained your PhD degree in the last three years (or submitted your thesis to the manuscript committee), in the field of molecular and/or cellular biology. You have a strong experimental background in molecular (genetic) research, including studies with DNA, RNA and/or protein (e.g. PCR, cloning, RT-PCR, Western Blot, immunocytochemistry), and cell culture. Hands-on experience with induced pluripotent stem cell (iPSC) culturing and differentiation is considered a strong plus.

You have strong communication skills (both orally and in writing), a critical scientific attitude, a high level of ambition, and should be able to work both independently as well as in a team. Finally, a high affinity and/or strong interest in drug development and translational research is needed.

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Terms of employment

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. But there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At...

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Terms of employment

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. But there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.

  • In addition to your monthly salary and an annual vacation allowance of 8%, you will receive an end-of-year bonus of 8.3%.
  • As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
  • Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
  • You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the CAO UMC.


Apply at Radboud university medical center

  • What can you expect when you apply for a job at Radboudumc?


Contact

All additional information about the vacancy can be obtained from Prof. Rob Collin , endowed professor . Use the Apply button to submit your application.

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Contact

All additional information about the vacancy can be obtained from Prof. Rob Collin, endowed professorUse the Apply button to submit your application.

The first interview round takes place on 17 May and 21 May 2021. We would appreciate it if you would take this into account. We would like to receive your application before Tuesday, May 11.

Applications should be accompanied by a strong motivation letter and CV, both in English, as well as names and contact information of two references. Preffered starting date: June 2021.

What else can you expect?
When you join us, we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. You do not have to do anything for this; we will tell you more later. Read more what our International Office can do for you when moving to the Netherlands, about the application process or view our frequently asked questions.

Recruitment agencies are asked not to respond to this job posting.

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