About the position
- 36 hours per week
- 4 years
- Salary scale 10A
- min € 2495 - max € 3196 gross per month for full-time employment
- Deadline: 10 May 2021
#weareradboudumc, what about you?
Your PhD project will focus on in and ex-vivo modelling and testing to enable optimized SIRT. It is our goal to translate the outcomes of this research project into a new calculated and better predicted treatment option for patients. Will you join our ambitious team?
The main goal in this project is to develop a method to optimize SIRT by investigating and ultimately altering the parameters that affect the distribution of the microspheres. The exact distribution of microspheres will be investigated in silico, ex vivo and in vivo, painting a complete picture of the mechanisms underlying SIRT. During the research we will comprise a survey and a brainstorm session with key opinion leaders in SIRT to collect possible parameters that can influence hepatic blood flow and/or microsphere distribution. At the start of the project analyses of the hepatic blood flow of healthy volunteers and patients will be performed. You will identify and segment the liver and its blood vessels (both the hepatic arteries and portal veins) based on Computer Tomography (CT) and Magnetic Resonance images (MRI)
Based on the survey and analysis you will collaborate with the other PhD candidate on the planning of 3d-printed hepatic vessel models. Your main tasks will be the set-up of an ex-vivo liver model. The main goal of the research is the testing of different microsphere sizes, numbers and compositions under imaging guidance to gain detailed information around the microsphere flow and distribution. Injection speed and catheter tip position (of different catheters) will be investigated in relation to the microspheres distribution. In the next steps ex-vivo perfused pig livers will be investigated with a selected amount of parameters. However, the similarity to the actual situation in the patient is limited.
Therefore, based on the results within the pig livers the imaging schedule and set-up of testing the parameters in ex-vivo human livers will be planned. The flow dynamics will be quantified with MRI or US. This setup and performance of the preclinical and clinical research will be part of your work. Analysis of human perfused ex-vivo livers will be performed in close cooperation with the department of surgery in the University Medical Center Groningen. Donor livers that were selected for liver transplantation but did not met the criteria for transplantation will be used. Liver perfusion of these livers is applied to simulate the real physiological situation in humans. Also, explanted livers with hepatocellular carcinoma, obtained during liver transplantation, will be used.
Finally, patients with liver tumors will be treated and the specific parameters will be investigated. Administration of the microspheres will be performed in fractions. All outcomes will be used to validate the computational planning system, the validated computational planning system is the final goal of this project.
Tasks and responsibilities
- Analysis of scientific data and the set-up of list of parameters that will be investigated.
- The research task will mainly focus on the development of an image guided ex-vivo and in-vivo animal and human model for testing the influence of blood flow and microsphere characteristics on the distribution of microspheres.
- Validating the mathematical model on Ex-vivo human liver and patients.
- Valorisation to the end users in collaboration with two other PhD candidates on this project
- Write scientific publications and present findings at (inter)national scientific meetings.
- Work in a team with other scientists and clinicians to plan, discuss, and perform research in a stimulating environment.
The Department of Medical Imaging of the Radboudumc Nijmegen is headed by Prof. Dr. Mathias Prokop. The Radboudumc is an academic center with focus on research, education and patient care. The department has extensive expertise in imaging and uses state-of the art CT, ultrasound, MRI and nuclear...read more
The Department of Medical Imaging of the Radboudumc Nijmegen is headed by Prof. Dr. Mathias Prokop. The Radboudumc is an academic center with focus on research, education and patient care. The department has extensive expertise in imaging and uses state-of the art CT, ultrasound, MRI and nuclear imaging. Advanced MRI facilities for both patient care and (animal experiments) research are available and accessible. Within the Department of Radiology oncology is an important focus of research and patient care. Both pre-clinical and clinical research can be performed in the animal lab (PRIME) and in the Medical Innovation & Technology expert Centre (MITeC), which is a conglomerate of three Operating Rooms (OR’s) in the newly built OR-complex in the Radboudumc.
The project Understandig Liver treatment to improve distribution (Ultimo)
Each year, over 1.5 million people worldwide develop liver tumors. Selective Internal Radiation Therapy (SIRT), also called radioembolization, is a treatment option for patients suffering from liver tumors that do not benefit from conventional therapy. During the treatment, radioactive microspheres are injected into the liver artery that supplies the tumor, where they lodge in and around the tumor and deliver a high local radiation dose. However, the outcomes vary greatly between individuals. It is not well known what factors give rise to these mixed outcomes.
In this project, we will unravel the fundamentals of SIRT, allowing for the development of a validated computational planning system to hand the clinician a tailor-made treatment plan per patient, resulting in optimal patient care and ultimately reaching an effective transfer of knowledge on SIRT from the technical starting point to the end users for whom the technique is applied: the affected patients. The project is funded by The Netherlands Organisation for Scientific Research (division Applied and Engineering Sciences; application number OTP 18427).
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.
Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc.
You have a Master’s degree in Clinical technology, Technical medicine, Medicine or Biomedical engineering with affinity for experiments in that area and demonstrated interest in solving complex modelling. Besides this you have an interest in high-tech medicine, clinical physics, experience with...read more
You have a Master’s degree in Clinical technology, Technical medicine, Medicine or Biomedical engineering with affinity for experiments in that area and demonstrated interest in solving complex modelling. Besides this you have an interest in high-tech medicine, clinical physics, experience with medical imaging techniques (CT, MRI, US, SPECT).
- You are eager to work on this multi-disciplinary translational project, in-depth pre-clinical feasibility and modelling studies in a laboratory and medical imaging environment combined with patient-related clinical research.
- A permit to work with radioactivity (or willing to obtain this permit).
- A permit to work with laboratory animals; article-9 (or willing to obtain this permit).
- Well-developed communicational and social skills directed towards working in a team.
- Enthusiastic and strong motivation to successfully complete a PhD.
Terms of employment
You will be positioned in the research group of Dr Frank Nijsen at the department of Medical Imaging, Radboudumc in Nijmegen and you will be part of a dynamic, multidisciplinary team. Within this project you will work together with two colleague PhD candidates located at the University of Twente ...read more
Terms of employment
You will be positioned in the research group of Dr Frank Nijsen at the department of Medical Imaging, Radboudumc in Nijmegen and you will be part of a dynamic, multidisciplinary team. Within this project you will work together with two colleague PhD candidates located at the University of Twente (Dr. Erik Groot-Jebbink) and Radboudumc. The (pre)clinical studies on human ex-vivo livers will be performed mainly at the department of surgery in the UMCG (supervisor Dr Koert P. de Jong, HPB Surgeon). Preclinical work on pig livers and the validation on patients treated with radioembolization will be performed in the Radboudumc.
Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. But there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.
- In addition to your monthly salary and an annual vacation allowance of 8%, you will receive an end-of-year bonus of 8.3%.
- If you work irregular hours, you will receive an allowance.
- As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
- Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
- You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
Apply at Radboud university medical center
What can you expect when you apply for a job at Radboudumc?
Read the frequently asked questions from applicants and of course the answers.
All additional information about the vacancy can be obtained from Dr. Frank Nijsen, Principal Investigator of the project. Use the Apply button to submit your application.
We would like to receive your application before Monday 10 May 2021. We will then contact you shortly.
The following should be included in your application: CV, letters of recommendation, list of completed courses and grades, a letter of motivation, and reprints or, preferably, links to your thesis or any scientific publications or reports in English that you have written.
What else can you expect?
When you join us, we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. You do not have to do anything for this; we will tell you more later. Read more what our International Office can do for you when moving to the Netherlands, about the application process or view our frequently asked questions.
We recruit for this vacancy ourselves. Acquisition is not appreciated, but sharing in your network is.