News items New treatment for ankle cartilage damage under development

14 August 2026

An innovative treatment for ankle cartilage damage is coming closer. Researchers at the University of Twente and Radboud university medical center, working within HealthTech Nexus, are developing a 3D-printed implant that could offer patients a less invasive alternative to current treatment options.

The implant, called AMPLANK, is specifically designed for patients with damaged ankle cartilage. At present, two surgical treatments are commonly used: ankle fusion (arthrodesis) and total ankle replacement. Both procedures are invasive and can limit the natural movement of the ankle.

AMPLANK aims to change that. The implant is custom-made for each patient and designed to fit within the limited space of the ankle joint without requiring the removal of healthy bone.

“Ankle cartilage damage can have a major impact on mobility and quality of life,” says researcher Athena Jalalian from the University of Twente. “With AMPLANK, we want to offer patients a new treatment option that better matches their anatomy and lifestyle.”

According to Dennis Janssen, Associate Professor at Radboudumc, modern 3D-printing technologies make it possible to design implants that closely match the damaged joint. “By creating patient-specific implants, we can improve the fit and potentially reduce the risk of complications.”

Photo: Dennis Janssen and Athena Jalalian discuss the 3D printed prototype of the implant.

Prototype phase

The research team is currently developing a prototype of the implant. This will be followed by extensive testing. First, computer simulations will be used to assess how the implant behaves within the joint. The implant will then be evaluated in an anatomical setting to verify its fit and performance.

In addition to the technical development, the researchers are working closely with ankle surgeons to design a safe and feasible surgical procedure.

The researchers see particular potential for young and active patients, for whom current treatment options are often far from ideal.

Collaboration within HealthTech Nexus

The project highlights the strength of HealthTech Nexus, the collaboration between the University of Twente and Radboudumc aimed at accelerating healthcare innovations. The initiative brings together expertise in medicine, materials science, biomechanics, and advanced 3D-printing technologies.

The Sint Maartenskliniek, the Fraunhofer Innovation Platform at the University of Twente, and several industrial partners are also contributing to the project.

If AMPLANK proves successful, the technology could potentially be applied to other joints for which treatment options are currently limited, including the shoulder, elbow, and wrist.

Read the full article here.

Photo top: A 3D model of the ankle is made first using an MRI scan. The new 3D printed implant can then be designed to fit precisely in the ankle.

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Margie Alders

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