Research groups - Radboudumc

Advanced X-ray Tomographic Imaging Lab (AXTI)

Ioannis Sechopoulos' research group focuses on novel image acquisition, processing and analysis techniques, physical and perceptual evaluation of image quality, radiation dosimetry, tomographic image reconstruction and advanced computational simulation methods in diagnostic x-ray based imaging.

Bacteriology

Heiman Wertheim's research group is primarily focused on the diagnostics of bacterial infections and antibiotic resistance.

Behavioural neurogenetics

Judith Homberg's research group focuses on genetic and environmental factors that influence brain development and behavioural traits. Interactions between these factors may lead to maladaptive emotional responses as seen in stress-related disorders and addiction.

Behavioural neuroscience

Benno Roozendaal's research investigates the brain processes underlying the effects of emotional arousal on memory processes. The goal is to increase understanding of traumatic memories in humans and develop new strategies for the prevention or treatment of memory- and anxiety disorders.

Biostatistics

Joanna in 't Hout's research group aims to improve the quality of statistical methods that are used by researchers.

Blindness genetics

Frans Cremers's group aims to identify the remaining causative retinal dystrophy genes and genetic defects underlying retinal dystrophy in the Netherlands before 2020.

Bridging the gap between science and practice for ADHD

Nanda Lambregts-Rommelse's research projects are bridging the gap between science and practice for attention-deficit/hyperactivity disorder (ADHD).

Cancer Epidemiology

Bart Kiemeney's research group learns as much as possible about cancer with the aim of reducing the burden of this disease. The emphasis lies on the detection of urological tumours and their genetic causes.

Cancer genomics

Richarda de Voer's research group focuses on the discovery of novel genetic variants that predispose to cancer and the investigation of the molecular pathways via which these variants initiate carcinogenesis.

Cancer Screening and Follow-Up

Mireille Broeders's research subgroup looks at whether there’s value to be gained in targeting the screening or follow-up policy to a person’s level of risk, by collecting information on risk factors from screening participants and patients.

Cardiovascular physiology and exercise

Dick Thijssen's research group focuses on the field of cardiovascular physiology and physical (in)activity. His work strongly focuses on understanding the impact of exercise training and physical activity on reducing the risk of developing cardiovascular and metabolic diseases.

Cellular neurophysiology

Dirk Schubert's group aims to improve our understanding of the neural networks in the rodent primary somatosensory system and answer general questions about how altered gene expression or neuromodulators can affect cortical network organization and consequently behavior.

Cerebral circulation and cognition in aging humans

Jurgen Claassen's group uses various techniques to measure cerebral perfusion, cerebral autoregulation and cognitive activation. These physiological mechanisms play an important role in Alzheimer’s disease, hypertension, and cognitive aging.

Cerebral circulation and cognition: Translational neurosciene

Amanda Kiliaan’s research group uses a multidisciplinary approach to study the link between (cerebro)vascular disorders and neurodegeneration. Within this group, neuroimaging is an important tool to study aspects of cerebral hemodynamics (e.g. cerebral blood flow/volume, vasoreactivity).

Cerebral perfusion in neurosurgery

Jurgen Fütterer and Mark ter Laan's group explores the feasibility and diagnostic accuracy of cerebral perfusion imaging in neurosurgery. We compare several techniques, and develop new applications for cerebral perfusion imaging in the Hybrid-OR.

Cerebrovascular disease

Frank Erik de Leeuw's group focus is on causes and cognitive consequences of cerebrovascular disease in the young and elderly.

Chemical immunology

Carl Figdor's research group studies chemical biology with a focus on the targeting of Dendritic Cells and a focus on developing synthetic Dendritic Cells to directly activate T cells.

Clinical molecular genetics of heterogeneous genetic disorders

Hans Scheffer's research focuses on the development of novel techniques, e.g. the application of next generation sequencing (NGS) techniques in research and diagnostics, in particular of neurogenetic disorders.

Clinical neurogenetics

Tjitske Kleefstra's aim is to improve care and management of rare genetic neurodevelopmental disorders (NDs) by constructing a concept of personalized healthcare. We aim to better understand the underlying neurocognitive and biological mechanisms to further investigate new therapeutic interventions.

Cochlear implantation: controlled electrode positioning with the help of 3D imaging

Emmanuel Mylanus's research group aims to improve performance of bilateral cochlear implantation, and investigate the effect of this treatment modality on patient outcome.

Cognitive and affective neuroscience

Erno Hermans's group investigates how neurochemicals affect diverse cognitive functions, such as vigilance, executive function, and memory. Moreover, they study how stressful experiences alter the intrinsic neural dynamics in the brain and how such processes contribute to memory.

Cognitive neuroscience of memory and emotion

Guillén Fernández aims to gain insights into the declarative memory system, a network of brain structures that enables us to remember events and facts. Particularly, we focus on memory formation, consolidation and retrieval and interaction between memory, and other domains, like stress and emotion.

Cognitive psychiatry

Indira Tendolkar's group focuses the intersection between clinical psychiatry and cognitive neuroscience with a focus on declarative memory. We investigate the adapatation of emotional and neutral memory processes depending on genetic and environmental variablity including somatic challenges.

Communication in healthcare

Sandra van Dulmen's research group studies process and outcome of everyday clinical interactions and design and test (eHealth) interventions.

Comparative genomics

Martijn Huijnen's research group exploits the wealth of ‘omics data to predict the function of proteins and their involvement in protein complexes and pathways. It thereby specifically focuses on the molecular systems that are of biomedical relevance.

Computational approaches to advance personalized medicine

Peter Bram 't Hoen's research group develops computational approaches that exploit molecular –omics data in combination with clinical data to better understand disease mechanisms and to advance patient diagnosis and stratification for therapeutic and life style interventions.

Computational pathology group

Jeroen van der Laak's research group develops, validates and deploys novel medical image analysis methods based on deep learning technology and focusing on computer-aided diagnosis.

Dendritic cell vaccination

Jolanda de Vries's research group focuses on dendritic cell vaccination. Dendritic Cell (DC) therapy represents a promising immunotherapeutic approach for the treatment of cancer.

Developmental epigenomics

Jo Zhou's group aims to establish disease models using patient material and model organisms to identify regulatory networks and disease mechanisms in developmental disorders. Using genomics technology, we map the genome-wide atlas of disease-associated regulatory elements beyond the coding regions.

Developmental neuropsychiatry

Jan Buitelaar's research is aimed at a better understanding of neuropsychiatric disorders, such as ADHD, autism, dyslexia and aggression-related disorders, at all levels.

Disorders in impulse- and aggression regulation

Robbert-Jan Verkes's group aims to understand the neurobiological impairments in individuals with disorders in impulse- and/or aggression control. Particular interest in the influence on impulsive behavior of psychotropic compounds, including the individual differences in the effects of these drugs.

Drosophila models of brain disorders and neurogenetics

Annette Schenck's research focuses on dissecting molecular networks and mechanisms underlying human brain function and disease. In order to be able to investigate the large number of genes, we use a powerful genetic model organism, the fruitfly Drosophila melanogaster.

Educational research in primary care

Nynke Scherpbier's research group initiates and evaluates educational innovations to promote effective medical education in undergraduate curricula and in postgraduate training and continuous professional development in primary care.

Elderly care medicine

Raymond Koopmans' research group focusses on research on people with dementia or neurological disorders.

Engineered proteins for drug delivery

Wouter Verdurmen’s research group focuses on designing and investigating engineered proteins that overcome delivery barriers, employing synthetic binding proteins for target recognition. Various (super-resolution) microscopy techniques as well as microfluidic tumor-on-a-chip approaches are used.

Establishing physiological biomarkers of perioperative stress

Jurgen Fütterer's group conducts imaging and cognitive research at the intersection between clinical psychiatry and cognitive neuroscience with a focus forms of declarative memory that also play a role in development and maintenance of stress-related mental disorders.

Evidence Based Surgery

Maroeska Rovers's research subgroup investigates which surgical techniques are being used and whether or not they are necessary.

Exercise physiology

Thijs Eijsvogels’ research group studies the acute and long-term effects of exercise on health. Current projects involve cardiac imaging following lifelong exercise training, optimizing cardiac rehab, assessing thermoregulatory responses in elite athletes and development of cooling strategies.

Experimental virology

Ronald van Rij's group studies virus-host interactions in both mosquito vector and mammalian host. By doing so, we hope to gain insights into arbovirus transmission and contribute to the development of novel antiviral therapy.

Gender in primary and transmural care

Sabine Oertelt-Prigione's research group has two goals regarding gender in primary and transmural care.

Gene regulatory network models for brain disorders

Kees Albers's research group is focused on the integration of computational and experimental approaches to understand how genetic variation causes disease. In particular we try to understand how dysregulation of gene expression may cause disorders of the brain.

Genetic epidemiology of brain traits and neuropsychiatric disorders

Alejandro Arias Vasquez's goal is to find genes involved in the variation of brain traits as well as for genes involved in the risk of complex neuropsychiatric diseases.

Genetic therapy for inherited retinal disease

Rob Collin's research group aimes at the development of new preclinical therapeutic strategies for selected genetic subtypes of inherited retinal dystrophy, by applying different approaches and using various cellular and animal models.

Genetics of brain function and (psychiatric) malfunction

Barbara Franke's works on the identification of risk genes for disease; in addition to using the classic clinical phenotypes they make use of intermediate phenotypes.

Genetics of multifactorial eye diseases

Anneke den Hollader's main goal is to understand the molecular disease mechanisms of common forms of vision loss. That will help determine which molecular factors can influence response to therapy.

Genome bioinformatics

Christian Gilissen's group develops and applies bioinformatics methods to gain insight into the causes and mechanisms of genetic disorders such as intellectual disability.

Genomic diseases

Joris Veltman's research focuses on genomic architecture and genomic disease, with a particular interest in the role of rare de novo mutations and structural variations in severe neurodevelopmental and prenatally lethal disease.

Genomic profiling in intellectual disability

Bert de Vries's research aims to phenotype patients with intellectual disability to identify genetic mutations and unravel genetic networks underlying intellectual disability.

Global HTA

Rob Baltussen's research subgroup supports countries around the world to set priorities in healthcare.

Glycosylation Disorders in Neurology

Dirk Lefeber's research group aims to understand the mechanisms of protein- and tissue-specific glycosylation abnormalities in human disease with a focus on neurodegenerative and neuromuscular disease.

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