In humans, the top layer of the skin is renewed every month. This frequent turn-over requires a robust regulation of the loss of cells from the surface and the production of new cells as replacements.Sabine Tanis from the lab of Klaas Mulder (see picture), theme Cancer develoment and immune defense, together with her collaborators, found that part of this robustness is conferred by functional connections between transcriptional/epigenetic and splicing regulation of genes involved in cell-cell contacts.
This work was recently published Open-Access in Cell Reports.
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