In humans, the top layer of the skin is renewed every month. This frequent turn-over requires a robust regulation of the loss of cells from the surface and the production of new cells as replacements.Sabine Tanis from the lab of Klaas Mulder (see picture), theme Cancer develoment and immune defense, together with her collaborators, found that part of this robustness is conferred by functional connections between transcriptional/epigenetic and splicing regulation of genes involved in cell-cell contacts.
This work was recently published Open-Access in Cell Reports.
Related news items
Podosome nanoscale architecture redefined20 November 2019
Koen van den Dries and Alessandra Cambi, theme Nanomedicine, revealed how the nanoscale architecture of podosomes enables dendritic cells to protrude and sense their extracellular environment. They have published their results in Nature Communications.read more
270 times Homo Universalis in Nijmegen20 November 2019
What does a scientist of the future look like? International young scientists addressed this important topic during the ENABLE conference, organized by young researchers for young researchers. They showed how the new generation of researchers wants to open up science to the public.read more
More expertise needed for patients with prolonged Disorder of Consciousness14 November 2019
Willemijn van Erp published in the Annals of Neurology that nearly 80% of people with Unresponsive Wakefulness Syndrome, formerly referred to as ‘vegetative state’, are not given a correct description of the diagnosis when they are discharged from the hospital.read more
1.5 million for research into young people with mild intellectual disabilities13 November 2019
Researchers from the Radboud University and Radboudumc will partner with social organisations to map how often young people with mild intellectual disabilities have psychological problems and how they can be treated. The project was recently awarded a subsidy of 1.5 million euro by ZonMw.read more