Chromatin regulatory complexes play an important role in regulating gene expression. How these complexes are recruited to their target sites remains an active area of investigation.The evolutionarily conserved Nucleosome Remodelling and Deacetylase (NuRD) complex is such a chromatin-associated protein complex. As the name implies, this complex combines two enzymatic functions: histone deacetylase activity and ATP-dependent chromatin remodelling activity. NuRD has been shown to play a role in gene expression regulation, stem cell self-renewal, and lineage commitment.
Researchers from the Michiel Vermeulen lab, led by Susan Kloet (r) and Ino Karemaker (l), used genome-wide profiling and quantitative interaction proteomics to study the dynamics of the NuRD complex during differentiation from mouse embryonic stem cells (ESCs) into neural progenitor cells (NPCs). They identified ZFP296 as a novel, ESC-specific NuRD-interacting protein that regulates genome-wide NuRD localisation as well as differentiation of ESCs.
This work, recently published in Nature Communications, provides a molecular basis for genome-wide NuRD localisation during ESC differentiation.
Related news items
650,000 Euro funding for research into the phasing out of medication for leukaemia patients30 July 2020
With a 650,000 euro funding from ZonMw, researchers from the Haematology and Pharmacy departments can develop a medication phasing out strategy for patients with chronic myeloid leukaemia. This strategy will be tested in practice.read more
Increased role of patients after bowel cancer treatment30 July 2020
Approximately 14,000 patients get colorectal cancer every year. Almost all patients are operated on and monitored afterwards (follow-up). In 2019 Radboudumc started a new approach to follow-up research after the treatment of stage II/III colorectal cancer.read more
ERC Proof of Concept grant received by Ronald van Rij30 July 2020
Ronald van Rij, theme Infectious diseases and global health, received an ERC (European Research Council) Proof of Concept grant of 150,000 euros, in order to make arbovirus vaccines even safer.read more
Hypatia fellowship Call is open30 July 2020
The Hypatia fellowship round with the deadline 31 May has been canceled. Therefore, the next available deadline will be 27 September 2020. Radboudumc researchers are invited to scout young potentials to fill the strategic gaps within the research themes imbedded in RIHS and RIMLS.read more
Mihai Netea and colleagues published two papers back-to-back in The Journal of Clinical Investigation.29 July 2020
These back-to-back articles investigated the effect of BCG vaccination on trained immunity. The first article shows that BCG vaccination inhibits systemic inflammation, depending on gender. The second article demonstrates that the circadian rhythm influences the induction of trained immunity.read more
Genetic mutation reveals how coronavirus strikes TLR7 plays essential role in disease process28 July 2020
''Does a congenital immune defect play an important role in the defense against Coronavirus?'' This was published by Cas van der Made, Frank van der Veerdonk and Alexander Hoischen.read more